Rosmarinic acid induces melanogenesis – through protein kinase A activation signaling
Silver bullet for cancer: Metal can kill some tumours better than chemotherapy with fewer side effectsSilver can kill some cancers as effectively as chemotherapy and with potentially fewer side effects, new research claims.–Scientists say that old wives tales about the precious metal being a ‘silver bullet’ to beat the Big C could be true.–The metal already has a wide range of medicinal uses and is a common antiseptic, antibiotic and means of purifying water in the third world. —Good news: Silver can kill some cancers as effectively as chemotherapy and with potentially fewer side effects, new research has claimed—And British researchers now say that silver compounds are as effective at killing certain cancer cells as a leading chemotherapy drug, but with potentially far fewer side-effects. —They compared it to Cisplatin, currently used to treat a wide variety of cancers, but known to have harsh side effects including nausea, vomiting and even kidney damage.—Silver is used already in everyday products such as deodorant with no known side-effects, and could make for a potentially cheaper alternative to platinum-based Cisplatin. –Researchers from the University of Leeds conducted lab tests which exposed breast and colon cancer cells to various silver-based chemicals over a six day period. –Results, published in journal Dalton Transactions, showed that these silver-compounds were ‘as effective as Cisplatin’ at killing cancer with potentially fewer side effects. –While the team are still unsure about how exactly silver battles cancer, they think its effectiveness may be caused by the structure surrounding silver atoms, known as its ligand. –Way forward: Researchers from the University of Leeds found that silver could be used to help defeat breast cancer —They think this may help release the silver ion into cells when it enters the body, killing any cancer. —Study author Dr Charlotte Willans plans to spend the next year looking closely at what effect silver has on both cancerous and healthy cells, and whether it could be a safe and effective new anti-cancer drug.–She said: ‘It’s certainly an exciting discovery, although I think we have a lot of work to do in the future. It opens the doors in terms of what we can do and investigate.—‘Getting these results also gives us the opportunity we need to apply for funding to take the research further.–‘This could lead to a cheaper, less toxic alternative to current treatments for cancer.‘–Explaining the research in greater detail, Dr Willans added: ‘As many are unfortunately aware, chemotherapy can be a very gruelling experience for the patient. —‘Finding effective, yet non-toxic drugs is an ongoing problem, but these preliminary results are an important step in solving it.–‘Our research has looked at the structure which surrounds a central silver atom. This “shrubbery” is what determines how reactive it is and what it will interact with. ‘Our research has used different types of these ligands to see which is the most effective against cancer cells.’
A School Nurse has written the info below—- Please share – because it really works!
“Apply a glob of liquid soap to a cotton ball. Cover the tick with the soap-soaked cotton ball and swab it for a few seconds (15-20); the tick will come out on its own and be stuck to the cotton ball when you lift it away.—–This technique has worked every time I’ve used it (and that was frequently), and it’s much less traumatic for the patient and easier for me..” —“Unless someone is allergic to soap, I can’t see that this would be damaging in any way. —I even had my doctor’s wife call me for advice because she had one stuck to her back and she couldn’t reach it with tweezers. She used this method and immediately called me back to say, “It worked
Stop the GM Apple! Take Action before June 3.
A small BC company called Okanagan Specialty Fruits has just submitted a request to Health Canada and the Canadian Food Inspection Agency for approval of a genetically modified (GM, also called genetically engineered) “non-browning” apple. Contamination from GM apples threatens the future of our apples, and the farmers who grow them.—
1. Send your comments to the Canadian Food Inspection Agency before June 3, 2012 at <http://active.inspection.gc.ca/eng/plaveg/bio/subs/biocome.asp> Tell the government that you don’t want to eat a GM apple!—- Consumers don’t want GM apples. – The GM “non-browning” apple will mislead consumers by presenting an apple that looks freshly cut or unbruised when it is not. – BC apple growers have already rejected the GM apple. – Contamination from GM apple trees is a risk to Canadian apple producers. – The CFIA and Health Canada should not be wasting public funds reviewing a GM apple that no one wants. – The government should consult with farmers and consumers before approving any new GM crop. —You can see the notice of the submission for approval of the GM apple at: <http://inspection.gc.ca/plants/plants-with-novel-traits/notices-of-submission/okanagan-specialty-fruits-inc-/eng/1335141426301/1335142810470>
This is just the first of many actions needed to stop the GM apple.
2. You can also sign a petition created by the British Columbia NDP here: <https://spreadsheets.google.com/spreadsheet/viewform?formkey=dEVua2pOc0ZjWjZNeVFhd1FRMmNwVGc6MQ>
3. For more information and to get more involved see http://www.cban.ca/apple
Background–The genetically modified (GM) ?non-browning? apple is engineered to keep from going brown after being cut. This apple is designed for fast food companies and other companies that use pre-cut apples. The technology was developed in Australia and was licensed by small BC company Okanagan Specialty Fruits.—Okanagan Specialty Fruits asked for approval in the US in March 2010 and has just asked for approval in Canada. The GM apple has not yet been approved anywhere in the world. BC apple growers stopped the GM apple from being field tested in Canada in 2001. The federal agricultural research station in Summerland in the Okanagan valley, an important fruit growing area, was preparing to start field trials but BC growers who were concerned about contamination stopped them from happening.—Many apple grower associations in Canada and the US oppose the GM apple, including the BC Fruit Tree Association.– This action alert was issued on May 18 2012 by Bee SAFE, the Canadian Biotechnology Action Network, GE Free BC, Okanagan Greens Society, True Food Foundation and Vigilance OGM.
Lucy Sharratt, Coordinator Canadian Biotechnology Action Network (CBAN) Collaborative Campaigning for Food Sovereignty and Environmental Justice Suite 206, 180 Metcalfe Street Ottawa, Ontario, Canada, K2P 1P5 Phone: 613 241 2267 ext. 25 Fax: 613 241 2506 firstname.lastname@example.org www.cban.ca
Stop the GM Apple: http://www.cban.ca/apple
Rosmarinic acid induces melanogenesis through protein kinase A activation signaling.
Source–Biospectrum Life Science Institute, SK Ventium 101-701, Dangjung Dong, Gunpo City, 436-776 Kyunggi-do, Republic of Korea.
Abstract–Melanogenesis is a physiological process that results in the synthesis of melanin pigments, which play a crucial protective role against skin photocarcinogenesis. In order to determine the effects of rosmarinic acid on melanogenesis and elucidate the molecular events of melanogenesis induced by rosmarinic acid, several experiments were performed in B16 melanoma cells. In this study, we showed that the melanin content and tyrosinase expression were increased by rosmarinic acid in a concentration-dependent manner. In addition, after the melanin content was increased by rosmarinic acid, it was reduced by H-89 and KT 5720, protein kinase A (PKA) inhibitors, but not by SB203580, a p38(mapk) inhibitor, or Ro-32-0432, a PKC inhibitor, which suggests the involvement of PKA in rosmarinic acid-induced melanogenesis. Consistent with this, rosmarinic acid induced the phosphorylation of CRE-binding protein (CREB), but had no effect on the phosphorylation of p38(mapk) or the inhibition of Akt phosphorylation. Additionally, rosmarinic acid induced the activation of cAMP response element (CRE) without having any effect on cAMP production, which suggests that rosmarinic acid-induced melanogenesis is mediated by PKA, which occurs downstream of cAMP production. This result was further confirmed by the fact that rosmarinic acid-induced phosphorylation of CREB was inhibited by H-89, but not by PD98059, a MEK1 inhibitor, or by LY294002, a phosphatidylinositol-3-kinase (PI3K) inhibitor. Rosmarinic acid-induced expression of tyrosinase protein was attenuated by H-89. Based on these results, we report for the first time that rosmarinic acid induces melanogenesis through PKA activation signaling.
Recipe—take the essential oil of rosemary-4 drops to an ounce of a carrier oil shake and or percuss and apply to skin—
Makinga Wash with a combination of these herbs and then filtering and bottling –can be used as a rince—a skin toner—
Making A tea out of Perilla as well with sage and peppermint is another method
When making the teas go 1:1 ration and make at the least a 2 pint of water in a pot—bring to boil then simmer it down to about half and pour several oz and drink
What is Rosmarinic acid? Rosmarinic acid
MW: 360.31-Formula: C18H16O8
Pure rosmarinic acid is a cream colored powder. Rosmarinic acid belongs to the group of polyphenols.
Health Benefits of Rosmarinic acid
Rosmarinic acid has antioxidant, anti-inflammatory and antimicrobial activities. -The antioxidant activity of rosmarinic acid is stronger than that of vitamin E. Rosmarinic acid helps to prevent cell damage caused by free radicals, thereby reducing the risk for cancer and atherosclerosis. Rosmarinic acid has anti-inflammatory properties. Perilla, rich in rosmarinic acid, is used for its anti-allergic activity. A study by Sanbongi C and colleagues (Clinical and Experimental Allergy, June 2004) have shown that the oral administration of rosmarinic acid is an effective intervention for allergic asthma. Another study by Youn J and colleagues (Journal of Rheumatology, June 2003) demonstrated that rosmarinic acid suppressed synovitis in mice and that it may be beneficial for the treatment of rheumatoid arthritis. Unlike antihistamines, rosmarinic acid prevents the activation of immune responder cells, which cause swelling and fluid formation. –Rosmarinic acid is also used for food preservation. In Japan the perilla extracts, rich in rosmarinic acid, is used the garnish and improve the shelf life of fresh seafood.–Rosmarinic acid is used to treat peptic ulcers, arthritis, cataract, cancer, rheumatoid arthritis and bronchial asthma. —Synonyms—Ros A, [[3-(3,4-Dihydroxyphenyl)-1-oxo-2E-propenyl]oxy]-3,4-dihydroxy- benzenepropanoic acid
Scientists switch mouse’s genes off and on with radio waves
Some laboratory mice were given specially engineered insuling-producing genes. These genes were then remotely activated using radio waves. This could mean a whole new field of medical procedures in which we turn genes on and off at will.[U1] —This breakthrough is the work of geneticists at New York’s Rockefeller University. It’s a pretty circuitous path from the initial burst of radio waves to the activation of the gene, and there’s still a lot of refinement and improvement that needs to be made before this can be used in medical treatments, but still – we’re talking about the ability to modify the behavior of genes without ever going inside a patient’s body.[U2] That’s a potentially colossal advance.–Admittedly, while the treatment itself is totally non-invasive, the researchers did first have to inject some nanoparticles onto the mice’s cells in order to affect their genes.[U3] It’s a bit of a complex process, but Nature has a good explanation of just what was involved—Friedman and his colleagues coated iron oxide nanoparticles with antibodies that bind to a modified version of the temperature–sensitive ion channel TRPV1, which sits on the surface of cells. They injected these particles into tumours grown under the skins of mice, then used the magnetic field generated by a device similar to a miniature magnetic-resonance-imaging machine to heat the nanoparticles with low-frequency radio waves. In turn, the nanoparticles heated the ion channel to its activation temperature of 42 °C. Opening the channel allowed calcium to flow into cells, triggering secondary signals that switched on an engineered calcium-sensitive gene that produces insulin. After 30 minutes of radio-wave exposure, the mice’s insulin levels had increased and their blood sugar levels had dropped.—The radio waves are ideal for this sort of remote manipulation because they can pass through thick layers of tissue, and they can be easily focused by the TRPV1 channel to affect only the desired target[U4] . Lead researcher Jeffrey Friedman says that, although this particular treatment had to do with insulin production, this isn’t actually meant specifically as a diabetes treatment. That’s a good thing, considering this treatment is massively more inefficient than many diabetes treatments currently available. Instead, this is just meant as a general proof of concept, and insulin production happens to be one of the easier gene activities to manipulate.–Even better, the researchers have already developed a way to achieve similar, albeit weaker, results without having to inject nanoparticles at all. They have developed cells that can grow their own required nanoparticles, meaning there would be no need to give patients strange chemicals or molecules. However, as Nature explains, this would still require growing tumors inside humans to actually get these cell cultures in place, which means the treatment isn’t yet ethically permissible in humans. It’s definitely early days yet, but this is one seriously intriguing line of research