Show notes Of the week September 21 2012

Precautions for Tick-Borne Disease Extend ‘Beyond Lyme’   Copper Benefits   Copper—and how it Protects   Copper Proves Effective Against New E. Coli Strains in New Study   Dry Copper Kills Bacteria On Contact   Work With Germ-Killing Copper Could Save Thousands of Lives   Copper Recipes ************************************************************************** Precautions for Tick-Borne Disease Extend ‘Beyond Lyme’   ScienceDaily (Sep. 7, 2012) — This year’s mild winter and early spring were a bonanza for tick populations in the eastern United States. Reports of tick-borne disease rose fast.—While Lyme disease is the most common tick-borne disease in the Northeast and Upper Midwest, new research results emphasize that it is not the greatest cause for concern in most Southeastern states.—The findings are published today in a paper in the journal Zoonoses and Public Health.—The majority of human-biting ticks in the North–members of the blacklegged tick species–cause Lyme disease, but these same ticks do not commonly bite humans south of mid-Virginia.-[U1] -Biologist Graham Hickling of the University of Tennessee, co-author of the paper, says many patients in Southeastern states, who become sick from a tick-bite, assume they have Lyme disease, but the odds of that being the case are low.—“Ticks in the eastern U.S. collectively carry more than a dozen agents that can cause human disease,” says Hickling.—“Here in Tennessee we regularly collect lone star ticks that test positive for Ehrlichia, [a tick-borne bacterial infection]. Lone stars are an aggressive species that account for most of the human bites that we see in this region. So ehrlichiosis has to be a big concern, yet most people have never heard of it.”—In contrast, says Hickling, there have been no confirmed reports to date of the Lyme disease pathogen among the sparse populations of blacklegged ticks found in Tennessee[U2] .–“The Southeast is dominated by different tick species than the ones that attack humans in the North,” says Ellen Stromdahl, an entomologist at the U.S. Army Public Health Command and lead author of the paper.—“The lone star tick is by far the most abundant tick in the Southeast, and which species of tick bites you is critical because different ticks carry different diseases. In the Southeast you are unlikely to be bitten by the blacklegged ticks that spread Lyme disease,” Stromdahl says.–Most bites in the Southeast are from the tick species that spread spotted fever rickettsiosis and ehrlichiosis, but not Lyme disease.–A complicating factor for public health officials is that tick species are on the move, as wildlife populations, forest habitats and weather patterns change across the continent.[U3]   This spring the Tennessee Department of Health, for example, reported a 500 percent increase in tick-borne rickettsiosis.—“Identifying health risks in the face of changing climates will be critical in coming years,” says Sam Scheiner, National Science Foundation program director for the joint NSF-National Institutes of Health Ecology and Evolution of Infectious Diseases (EEID) program, which funds Hickling’s research.–At NSF, the EEID program is co-funded by the Directorates for Biological Sciences and Geosciences.–“This study will inform public health officials about what diseases are found in which areas,” says Scheiner, “so they can minimize human health problems.”–Hickling’s work is also in collaboration with scientist Jean Tsao of Michigan State University and is part of an EEID project to identify the ecological factors leading to distributions of tick species and pathogens–in particular, where the Lyme disease tick and pathogen are found.–Lyme-infected blacklegged ticks are expanding south through Virginia, and lone star ticks are moving north, [U4] the scientists have found.–The bite of the lone star tick can create a bulls-eye rash that appears like that of Lyme disease, but the rash isn’t caused by the Lyme bacteria.—The scientists say that this almost certainly leads to misdiagnosis of some patients in mid-Atlantic states, where both tick species are common.—The best way to distinguish Lyme from other tick-borne diseases is to be vigilant for tick bites, and whenever possible save any tick that manages to bite you, the biologists recommend. Store the tick in your freezer or in a vial of alcohol so it can be identified if you become ill.—In the Northeast, Lyme disease awareness campaigns have focused public attention on the nymphal blacklegged tick–which is responsible for most disease transmission and which is tinier than the adult form.–While nymphal blacklegged ticks and nymphal lone star ticks–which also bite humans–can be distinguished, the two are often confused by the public.–In one study, 13 of 20 patients reporting tick bites to physicians were given antibiotics on the assumption that they were at risk for Lyme disease, yet 53 of the 54 ticks removed from those same patients were lone star ticks, which do not spread Lyme disease.—“Where you live determines which tick species is likely to bite you,” says Tsao, “and therefore which diseases you’re most likely to contract.”–The biologists say they are happy that recent treatment recommendations have begun to emphasize the importance of considering the tick species and its infection status as part of the diagnostic process.–Their advice: Stay open-minded about which tick-borne diseases are most common in your area–and save the tick that bites you.–Story Source-The above story is reprinted from materials provided by National Science Foundation. —Journal Reference–E. Y. Stromdahl, G. J. Hickling. Beyond Lyme: Aetiology of Tick-borne Human Diseases with Emphasis on the South-Eastern United States. Zoonoses and Public Health, 2012; 59: 48 DOI: 10.1111/j.1863-2378.2012.01475.x ************************************************************************ Copper Benefits— Aneurysm may occur as a result of Copper deficiency.  –Copper may help to prevent abnormal Blood Clotting.-Copper deficiency may cause Congestive Heart Failure. -Copper is involved in the production of Red Blood Cells (via its involvement in the production of Hemoglobin). -Copper (in correct dosages) may enhance the health of the Heart-Optimal Copper levels may help to prevent damage to the Cardiac Muscle (i.e. the Muscle of the Heart).  —Cells–Impaired Growth may occur as a result of Copper deficiency.  —Digestive System—Many Celiac Disease patients are found to be deficient in Copper (indicating that supplemental Copper may benefit Celiac Disease patients). –Infant Diarrhea may occur as a result of Copper deficiency. –Eyes/Vision—Optimal Copper levels may help to prevent Cataracts. — Increased susceptibility to Bacterial & Viral Diseases (infections) may occur as a result of Copper deficiency: references- Copper may be a useful treatment for Acquired Immune Deficiency Syndrome (AIDS) patients (Copper inhibits HIV Protease, a component of the HIV virus)–However it has not yet been proven (nor disproven) that supplemental Copper can inhibit HIV Protease in vivo (within the body) as opposed to in vitro (in the test tube).—Optimal Copper levels may enhance the body’s resistance to Candida albicans proliferation.  Copper may be essential for the proper function of the Immune System and damage to the Immune System may occur as a result of Copper deficiency—Copper deficiency may reduce the production of Antibodies. Copper may be essential for the production of Neutrophils – Neutropenia (low Neutrophils count) may occur as a result of Copper deficiency. – Copper is involved in the formation of Bones—Copper may be required for the healing of Fractures (due to Copper being an essential component of the Lysyl Oxidase enzyme that catalyzes the final step in the synthesis of Collagen which is essential for the healing of Fractures) and supplemental Copper may accelerate the healing of Fractures.  People who are deficient in Copper may be more susceptible to Fractures.Osteoporosis may occur as a result of Copper deficiency.  Copper is required for the health of Connective Tissues–Copper may stimulate the (desirable) cross-linking of Collagen fibers (by activating the Lysyl Oxidase enzyme). -Copper may stimulate the formation of Elastin in Connective Tissues. —33% of the body’s Copper concentrates in the Muscles.–        Copper may alleviate Rheumatoid Arthritis—Copper bracelets may react with the Fatty Acids in the Skin to form Copper salts which are able to be absorbed into the Skin (this has been scientifically validated).—The Copper Salicylate form of Copper (consumed orally or applied topically) may be an effective treatment for the symptoms of Rheumatoid Arthritis and claimed to be the best form of Copper for the treatment of Rheumatoid Arthritis (due to it very closely mimicking the function of Superoxide Dismutase (SOD), a natural Antioxidant enzyme).  Vitiligo may occur as a result of Copper deficiency. —   Copper—and how it Protects   Copper Can Help In The Battle Against Influenza A H1N1, Says Scientist ScienceDaily (July 24, 2009) — A leading microbiologist from the University of Southampton has told a conference that his research has found copper is effective in inhibiting the influenza A H1N1 virus.—Copper appears to have broad spectrum antiviral activity because it is also effective, not only against RNA-based influenza, but also against DNA-based adenovirus 40/41 which causes gastrointestinal infections.—Speaking at the BIT Life Sciences 2nd Annual World Summit on Antivirals in Beijing, China this week, Professor Bill Keevil, from the University’s School of Biological Sciences, added that he believed copper could be used to reduce the spread of flu in public places.—“With the ongoing threat of contamination by influenza A viruses, such as H1N1, there is a real and pressing need to utilise all appropriate and effective measures with proven antimicrobial qualities,” commented Professor Keevil. “It is recognised that many infectious diseases are spread by hand contact and studies have now repeatedly shown that the use of copper as a surface material in key public places such as hospitals and food preparation areas offers the potential to substantially restrict and reduce the spread of harmful infection”. The influenza aspect of the study, completed in 2007, involved a series of experiments testing incubation of influenza A on copper and stainless steel surfaces. Results showed that, after incubation for 1 hour on copper, 75% of the virus was eradicated, and after 6 hours, less than 500 viral particles remained active (greater than 99.99% or 10,000-fold decrease). Similar inactivation rates have now been observed for adenovirus 40/41.–Professor Keevil added: “These public health benefits, supported by extensive antimicrobial efficacy testing, are underpinned by the fact that copper, brass and bronze are capable of killing a range of harmful and potentially deadly micro-organisms.”–The study has contributed further to the understanding of copper’s antimicrobial qualities, which actively inhibit the growth of bacteria, fungi and viruses.–Story Source-The above story is reprinted from materials provided by University of Southampton, via AlphaGalileo. ************************************************************************ Copper Proves Effective Against New E. Coli Strains in New Study ScienceDaily (June 2, 2011) — As the World Health Organisation suggests the E. coli outbreak in Germany is a strain never before seen in an outbreak — O104:H4 — laboratory science conducted at the University of Southampton indicates a role for copper in preventing the spread of such infections.—Professor Bill Keevil, Head of the Microbiology Group and Director of the Environmental Healthcare Unit at the University of Southampton, explains: “A study looking at copper’s efficacy against new strains of E. coli has just been completed. Although it did not specifically look at O104, all the strains investigated have died rapidly on copper.”—On a dry copper surface, the study shows 10 million E. coli bacteria are eliminated within 10 minutes. On a wet copper surface, one could expect a total kill within around 45 minutes. This antimicrobial property is inherent to the metal, and shared with alloys such as brass and bronze.—In the wake of this outbreak, hand washing and careful food preparation have been highlighted as key concerns, as has cross-contamination. Any raw food placed on a work surface can contaminate other food, or have bacteria transferred onto it from previous items resting there.[U5]  Deployed as a touch surface in food preparation areas, copper will continuously kill any pathogens that settle on it, reducing the risk of cross-contamination, and helping to prevent the spread of infection.–Professor Keevil will be presenting his findings at the forthcoming WHO International Conference on Prevention and Infection Control in Geneva on 30 June.–Story Source-The above story is reprinted from materials provided by University of Southampton, via EurekAlert!, a service of AAAS. **************************************************************************** Dry Copper Kills Bacteria On Contact ScienceDaily (Feb. 22, 2011) — Metallic copper surfaces kill microbes on contact, decimating their populations, according to a paper in the February 2011 issue of the journal Applied and Environmental Microbiology. They do so literally in minutes, by causing massive membrane damage after about a minute’s exposure, says the study’s corresponding author, Gregor Grass of the University of Nebraska, Lincoln. This is the first study to demonstrate this mechanism of bacteriocide.—“When microbes were exposed to copper surfaces, we observed contact killing to take place at the rate of tens to hundreds of millions of bacterial cells within minutes,” says Grass. “This means that usually no live microorganisms can be recovered from copper surfaces after exposure.”—Thus, such surfaces could provide a critical passive defense against pathogens in hospitals, where hospital-acquired infections are becoming increasingly common and costly, killing 50,000-100,000 Americans annually, and costing more than $8 billion, according to one estimate. Still, Grass cautions that “metallic copper surfaces will never be able to replace other hygiene-improving methods already in effect,” although they “will certainly decrease the costs associated with hospital-acquired infections and curb human disease as well as save lives.” However, he expects this strategy to be inexpensive, because “the effect does not wear off.”—Critically, the researchers provide strong evidence that genotoxicity through mutations and DNA lesions is not a cause of dry copper’s antimicrobial properties. This is important, because mutations can cause cancer in animals and humans, and the lack of such mutations in bacteria from copper means that copper does not endanger humans.—The relevant experiment was particularly interesting. The bacterium, Deinococcus radiodurans, is unusually resistant to radiation damage, as its DNA repair mechanisms are especially robust. The hypothesis: if metallic copper kills by causing DNA damage, D. radiodurans should be immune to copper. It is not.[U6] It is important to note that only dry copper surfaces are amazingly lethal to bacteria. The difference between dry and wet surfaces, such as copper pipes, is that only dry surfaces are inhospitable environments for bacterial growth. Bacteria can easily grow and reproduce in wet environments, and in so doing, they can develop resistance to copper. Resistance has not been observed to develop on dry copper surfaces.—-Story Source:– Journal Reference-C. E. Santo, E. W. Lam, C. G. Elowsky, D. Quaranta, D. W. Domaille, C. J. Chang, G. Grass. Bacterial Killing by Dry Metallic Copper Surfaces. Applied and Environmental Microbiology, 2010; 77 (3): 794 DOI: 10.1128/AEM.01599-10 **************************************************************************** Work With Germ-Killing Copper Could Save Thousands of Lives   Roberto del Rio Children’s Hospital, the oldest pediatric facility in Chile, installed antimicrobial copper surfaces in its intensive care and treatment rooms to reduce the risk of infection. The installation was a first for Latin America, following a growing number of installations in Europe, Asia and North America. –ScienceDaily (Sep. 7, 2012) — When Adam Estelle graduated from the University of Arizona’s materials science and engineering program four years ago, he had no idea he would be involved in saving thousands of lives.–Like most graduates, he was just hoping to find a job — preferably in Tucson, Ariz., because he wasn’t interested in big-city life. What happened next was a job offer from the Copper Development Association in New York City.–The technology is based on copper alloys that kill bacteria, fungi and viruses. The metals can be fashioned into everything from IV poles to sinks to bed rails — just about anything that is frequently touched in hospitals.—While these surfaces might look benign, they’re covered with organisms that contribute to hospital-acquired infections, the fourth leading cause of death in the United States, killing more people than AIDS and breast cancer combined. That’s 2 million infections annually, and 100,000 deaths — one infection for every 20 people admitted to hospitals.–While disease-causing organisms can lurk on stainless steel surfaces for two weeks, according to a recent UA research study, 99.9 percent die within two hours on surfaces that contain at least 60 percent copper, Estelle says.—Estelle has been working with four other engineers at the Copper Development Association, a not-for-profit trade group, to develop a market for copper alloys in the health care industry. They also have been helping manufacturers gear up for producing copper alloy products.–Part of that effort has involved gaining EPA certification for the antimicrobial effects of copper so manufacturers can advertise the health benefits of these products. The second part, which has been Estelle’s major focus for the past two years, was to retrofit the Ronald McDonald House in Charleston, S.C., with copper alloy stair railings, door hardware, sinks, faucets, counter tops, kitchen tables, chair arms, and other surfaces that are frequently touched by patients, visitors and staff.–This has been a win-win for everyone, Estelle explained, creating a safer environment for families and children, while at the same time helping the first wave of manufacturers tool up and commercialize lines of copper products that can now be marketed to hospitals.–“One of our first commercial products is a beautiful seamless counter top and sink bowl manufactured by Elkay Commercial Products,” Estelle said. “We installed about forty of these in the Ronald McDonald House.” Elkay is among ten manufacturers now marketing antimicrobial copper alloy products to the health care industry.–Surfaces at the Ronald McDonald House were swabbed and tested for bacteria for ten weeks before the new copper alloy products were installed. “Follow-up tests on the items converted to copper showed they carried 94 percent fewer bacteria,” Estelle said. “We are now trying to recreate the Charleston project at other Ronald McDonald Houses around the world to create a safer living and working environment for the children, families and staff.”—Now, with the Ronald McDonald House pilot project completed and EPA approval secured, the next step is to convince hospitals to replace traditional surfaces that are not worn out with copper alloy ones. New policies from the Centers for Medicare and Medicaid Services that go into effect next year should help spur this changeover. Treatment for hospital-acquired infections costs between $35 billion and $45 billion each year in the U.S., and Medicare and Medicaid will no long reimburse hospitals for that treatment if the infections are judged to have been preventable and a hospital mistake.–But even without the new rules, the changeover makes economic sense, Estelle explained. Under today’s reimbursement system, individual hospitals spend $5 million on average each year to treat infections. “Even on the low end, it’s $30,000 per infection,” he said. Clinical trials at three hospitals funded by the U.S. Department of Defense have recently proved that copper surfaces can reduce infections in the intensive care unit by more than 50 percent.–Using published estimates, about 500,000 Americans will contract an infection this year in the ICU. This will cost our hospitals an additional $3.5 billion in treatment, and about 40,000 people will not survive the ordeal. The clinical trial results suggest that installing copper surfaces could cut these figures in half.—“By implementing these surfaces, hospitals can see real, continuous savings year after year,” Estelle said. “This is a passive way to prevent infection that doesn’t depend on human behavior, such as hand-washing or hydrogen peroxide vapor machines. There is no need for maintenance beyond the normal surface cleaning procedures that are already in place.”—,.”Story Source–The above story is reprinted from materials provided by University of Arizona College of Engineering, via Newswise.   ***********************************************************************   Copper Recipe — Chlorophyll2 table spoons—vitamin C 3 grams and Zinc 30-50 mgs-manganese 8 mgs—-mix your Vitamin C and chlorophyll in a tiny glass—and consume them—cahse with water or juice or cool tea afterwards—this will Boost S O D in both the mitochandria and the cells—the combination should as well boost the immune system on several fronts and stabilizing Glutathione as well   Copper Colloidal—1  -2 tablespoon 3 grams of vitamin C  and Salicyclic acid 50 mgs—and 2 oz of water –Mix well and consume this  will alleviate pain in moments and will kill of viral and bacterial pathogens   You can also do this in dry form 3 grams of Vitamin C—2 mgs of copper and 30 mgs of zinc and the salicyclic acid 50 mgs-may find relief with this for hours

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Show of the Month September 10- 2012

Cynarin-rich sunflower (Helianthus annuus) sprouts possess both antiglycative and antioxidant activities   Ig Human and Soil Bacteria Swap Antibiotic-Resistance Genes   Aspirin May Lower the Risk of Pancreatic Cancer   Daily Aspirin Usage Linked to Lower Cancer Mortality   Growing Strong Muscles Without Working Out ************************************************************************** Cynarin-rich sunflower (Helianthus annuus) sprouts possess both antiglycative and antioxidant activities. J Agric Food Chem. 2012 Mar 28;60(12):3260-5 Authors: Sun Z, Chen J, Ma J, Jiang Y, Wang M, Ren G, Chen F Abstract
The present study examined the antiglycative and antioxidant properties of four edible sprouts popular in Chinese markets. In a protein-reducing sugar model, the sunflower sprout Helianthus annuus exhibited the strongest inhibitory effects against the formation of advanced glycation end products (AGEs).[U1]  At a concentration of 1.0 mg/mL, its inhibitory rate achieved 83.29%, which is stronger than that of aminoguanidine (1 mM), a well-known synthetic antiglycative agent (with an inhibitory rate of 80.88%). The antioxidant capacity of H. annuus was also much stronger than other sprout samples in terms of free radical scavenging and reducing properties. An active ingredient contributing to the observed activities was identified as cynarin (1,5-dicaffeoylquinic acid). This is the first report of the novel function of cynarin to intervene against glycoxidation. Given the key roles of AGEs and oxidation in the pathogenesis of diabetes, the sunflower sprout H. annuus rich in cynarin may be regarded as a beneficial food choice for diabetic patients.—PMID: 22394088 [PubMed – indexed for MEDLINE] ************************************************************************** Ig Human and Soil Bacteria Swap Antibiotic-Resistance Genes   Escherichia coli bacteria of the strain O157:H7. Soil bacteria and bacteria that cause human diseases have recently swapped at least seven antibiotic-resistance genes.)—-ScienceDaily (Aug. 30, 2012) — Soil bacteria and bacteria that cause human diseases have recently swapped at least seven antibiotic-resistance genes, researchers at Washington University School of Medicine in St. Louis report Aug. 31 in Science.According to the scientists, more studies are needed to determine how widespread this sharing is and to what extent it makes disease-causing pathogens harder to control.—-“It is commonplace for antibiotics to make their way into the environment,” says first author Kevin Forsberg, a graduate student. “Our results suggest that this may enhance drug resistance in soil bacteria in ways that could one day be shared with bacteria that cause human disease.”—[U2] Among the questions still to be answered: Did the genes pass from soil bacteria to human pathogens or vice versa? And are the genes just the tip of a vast reservoir of shared resistance? Or did some combination of luck and a new technique for studying genes across entire bacterial communities lead the scientists to discover the shared resistance genes?–Humans only mix their genes when they produce offspring, but bacteria regularly exchange genes throughout their lifecycles. This ability is an important contributor to the rapid pace of bacterial evolution. When a bacterial strain develops a new way to beat antibiotics, it can share the strategy not only with its descendants but also with other bacteria. Earlier studies by other scientists have identified numerous resistance genes in strains of soil bacteria. However, unlike the seven genes described in this report, the earlier genes were dissimilar to their analogs in disease-causing bacteria, implying that they had crossed between the bacterial communities a long time ago.—Most of the antibiotics used to fight illness today originated from the soil. Bacteria use the antibiotics, in part, as weapons to compete with each other for resources and survival. Scientists have long acknowledged that gives environmental bacteria an evolutionary incentive to find ways to beat antibiotics.–“We wanted to try to get a broader sense of how often and extensively antibiotic-resistance genes are shared between environmental bacteria and pathogens,” says senior author Gautam Dantas, PhD, assistant professor of pathology and immunology.—The researchers isolated bacteria from soil samples taken at various U.S. locations. The bacteria’s DNA was broken into small chunks and randomly inserted into a strain of Escherichia coli that is vulnerable to antibiotics. Scientists treated the altered E. coli with multiple antibiotics.—“We knew that any E. coli that continued to grow after these treatments had picked up a gene from the soil bacteria that was helping it fight the antibiotics,” Forsberg says. Scientists took the DNA from soil bacteria out of the surviving E. coli and prepared it for high-throughput sequencing. Dantas’ laboratory has developed techniques that make it possible to simultaneously sequence and analyze thousands of chunks of DNA from many diverse microorganisms. The DNA can be selected for a single function, such as antibiotic resistance. When the scientists compared antibiotic-resistance genes found in the soil bacteria to disease-causing bacteria, they were surprised to find some genes were identical not only in the sections of the genes that code for proteins but also in nearby non-coding sections that help regulate the genes’ activities.–Since bacteria have such large population sizes and rapid reproduction times, their DNA normally accumulates mutations and other alterations much more quickly than the DNA of humans. The lack of changes in the resistance genes identified in the study suggests that the transfers of the genes must have occurred fairly recently[U3] , according to Dantas.-In some soil bacteria, the genes are present in clusters that make the bacteria resistant to multiple classes of antibiotics, including forms of penicillin, sulfonamide and tetracycline.—“I suspect the soil is not a teeming reservoir of resistance genes,” Dantas says. “But if factory farms or medical clinics continue to release antibiotics into the environment, it may enrich that reservoir, potentially making resistance genes more accessible to infectious bacteria.”–Story Source-The above story is reprinted from materials provided by Washington University School of Medicine. The original article was written by Michael C. Purdy. —Journal Reference-K. J. Forsberg, A. Reyes, B. Wang, E. M. Selleck, M. O. A. Sommer, G. Dantas. The Shared Antibiotic Resistome of Soil Bacteria and Human Pathogens. Science, 2012; 337 (6098): 1107 DOI: 10.1126/science.1220761   ********************************************************************* Aspirin May Lower the Risk of Pancreatic Cancer ScienceDaily (Apr. 10, 2011) — The use of aspirin at least once per month is associated with a significant decrease in pancreatic cancer risk, according to results of a large case-control study presented at the AACR 102nd Annual Meeting 2011, held in Orlando, Florida, April 2-6.— For the current study, Tan and colleagues enrolled 904 patients who had documented pancreatic cancer and compared them with 1,224 healthy patients. All patients were at least 55 years old and reported their use of aspirin, NSAIDs and acetaminophen by questionnaire.–Results showed that people who took aspirin at least one day during a month had a 26 percent decreased risk of pancreatic cancer compared to those who did not take aspirin regularly. The effect was also found for those who took low-dose aspirin for heart disease prevention at 35 percent lower risk, according to Tan.—The researchers did not see a benefit from non-aspirin NSAIDs or acetaminophen. “This provides additional evidence that aspirin may have chemoprevention activity against pancreatic cancer,” said Tan. He added that more data must be gathered before we can prove a real benefit.–Story Source-The above story is reprinted from materials provided by American Association for Cancer Research. ********************************************************************** Daily Aspirin Usage Linked to Lower Cancer Mortality ScienceDaily (Aug. 10, 2012) — A large new observational study finds more evidence of an association between daily aspirin use and modestly lower cancer mortality, but suggests any reduction may be smaller than that observed in a recent analysis. The study, appearing early online in the Journal of the National Cancer Institute (JNCI), provides additional support for a potential benefit of daily aspirin use for cancer mortality[U4] , but the authors say important questions remain about the size of the potential benefit. —A recent analysis pooling results from existing randomized trials of daily aspirin for prevention of vascular events found an estimated 37% reduction in cancer mortality among those using aspirin for five years or more. But uncertainty remains about how much daily aspirin use may lower cancer mortality, as the size of this pooled analysis was limited and two very large randomized trials of aspirin taken every other day found no effect on overall cancer mortality.—For the current study, American Cancer Society researchers led by Eric J. Jacobs, Ph.D., analyzed information from 100,139 predominantly elderly participants in the Cancer Prevention Study II Nutrition Cohort who reported aspirin use on questionnaires, did not have cancer at the start of the study, and were followed for up to 11 years. They found daily aspirin use was associated with an estimated 16% lower overall risk of cancer mortality, both among people who reported taking aspirin daily for at least five years and among those who reported shorter term daily use. The lower overall cancer mortality was driven by about 40% lower mortality from cancers of the gastrointestinal tract (such as esophageal, stomach, and colorectal cancer) and about 12% lower mortality from cancers outside the gastrointestinal tract.———The reduction in cancer mortality observed in the current study is considerably smaller than the 37% reduction reported in the recent pooled analysis of randomized trials. The authors note that their study was observational, not randomized, and therefore could have underestimated or overestimated potential effects on cancer mortality if participants who took aspirin daily had different underlying risk factors for fatal cancer than those who did not. However, the study’s large size is a strength in determining how much daily aspirin use might lower cancer mortality.—“Expert committees that develop clinical guidelines will consider the totality of evidence about aspirin’s risks and benefits when guidelines for aspirin use are next updated,” said Dr. Jacobs. “Although recent evidence about aspirin use and cancer is encouraging, it is still premature to recommend people start taking aspirin specifically to prevent cancer. Even low-dose aspirin can substantially increase the risk of serious gastrointestinal bleeding. Decisions about aspirin use should be made by balancing the risks against the benefits in the context of each individual’s medical history. Any decision about daily aspirin use should be made only in consultation with a health care professional.”–Story Source-The above story is reprinted from materials provided by American Cancer Society, via EurekAlert!, a service of AAAS. -Journal Reference-Eric J. Jacobs, Christina C. Newton, Susan M. Gapstur, Michael J. Thun. Daily Aspirin Use and Cancer Mortality in a Large US Cohort. Journal of the National Cancer Institute, August 10, 2012 DOI: 10.1093/jnci/djs318 ************************************************************************* Growing Strong Muscles Without Working Out? ‘Hulk’ Protein, Grb10, Controls Muscle Growth ScienceDaily (Aug. 30, 2012) — Scientists have moved closer toward helping people grow big, strong muscles without needing to hit the weight room. Australian researchers have found that by blocking the function of a protein called Grb10 while mice were in the womb, they were considerably stronger and more muscular than their normal counterparts. This discovery appears in the September 2012 issue of The FASEB Journal. Outside of aesthetics, this study has important implications for a wide range of conditions that are worsened by, or cause muscle wasting, such as injury, muscular dystrophy, Type 2 diabetes, and problems produced by muscle inflammation.—“By identifying a novel mechanism regulating muscle development, our work has revealed potential new strategies to increase muscle mass,[U5] ” said Lowenna J. Holt, Ph.D., a study author from the Diabetes and Obesity Research Program at the Garvan Institute of Medical Research in Sydney, Australia. “Ultimately, this might improve treatment of muscle wasting conditions, as well as metabolic disorders such as Type 2 diabetes.”—To make this discovery, Holt and colleagues compared two groups of mice. Once group had disruption of the Grb10 gene, and were very muscular. The other group, where the Grb10 gene was functional, had normal muscles. Researchers examined the properties of the muscles in both adult and newborn mice and discovered that the alterations caused by loss of Grb10 function had mainly occurred during prenatal development. These results provide insight into how Grb10 works, suggesting that it may be possible to alter muscle growth and facilitate healing, as the processes involved in muscle regeneration and repair are similar to those for the initial formation of muscle.[U6] –“Don’t turn in your gym membership just yet,” said Gerald Weissmann, M.D., Editor-in-Chief of The FASEB Journal. “If you want big muscles, the classic prescription still applies: lift heavy things, eat and sleep right, and have your hormones checked. But this study shows that when we understand the basic science of how muscle fibers grow and multiply, we will be able to lift the burden — literally — of muscle disease for many of our patients.”—Story Source-The above story is reprinted from materials provided by Federation of American Societies for Experimental Biology, via EurekAlert!, a service of AAAS. –Journal Reference-L. J. Holt, N. Turner, N. Mokbel, S. Trefely, T. Kanzleiter, W. Kaplan, C. J. Ormandy, R. J. Daly, G. J. Cooney. Grb10 regulates the development of fiber number in skeletal muscle. The FASEB Journal, 2012; 26 (9): 3658 DOI: 10.1096/fj.11-199349   TOP B  

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Show of the Month September 7 2012

How Long Will Homemade Colloidal Silver    Candida albicans yeast-hyphal transition and biofilm formation Its Potency Inhibition by Solidago virgaurea water extracts   Parthenolide, a sesquiterpene lactone, expresses multiple anti-cancer and anti-inflammatory activities   After-Birth Abortion- Eugenicists Say Babies are a Parasitic Burden on Society   Thyme May Be Better for Acne Than Prescription Creams ************************************************************************** How Long Will Homemade Colloidal Silver Last Before It Begins to Lose Its Potency   How Long Will Homemade Colloidal Silver Last Before It Begins to Lose Its Potency? Tens of thousands of people throughout North America and around the world now make their own home-made colloidal silver using colloidal silver generators.   By far the #1 question — How long will a batch of homemade colloidal silver last before it begins to lose its potency?   Rule of Thumb— If you know what sign to look for, colloidal silver will tell you when it’s beginning to lose potency. –The general rule of thumb is to watch for precipitation of silver particles in your storage container. — “Precipitation” means the silver particles are beginning to fall out of suspension in the solution. The resulting residue will begin to visibly coat the sides or bottom of your storage container. That is the sure sign that your batch of homemade colloidal silver (or even store bought colloidal silver, for that matter) is beginning to lose its potency.—All you have to do is examine your storage container to see whether or not a light silver-gray residue is beginning to form on the sides or bottom of the container. — If you’re using a dark glass storage container, such as the amber glass bottles many people like to store their homemade colloidal silver in (see photo above), you may have to hold the bottle up to a bright light, or shine a flashlight through it, and carefully examine the sides and bottom. –If you see a coating or discoloration beginning to form on the glass sides or bottom, then you know your silver particles are beginning to precipitate, the batch is losing its potency, and it’s time to make a fresh batch. –Otherwise, if there is no visible residue forming in your storage container, your homemade colloidal silver is likely as fresh and potent as the day you made it.   Why Do Silver Particles Fall Out of Suspension?   There are a number of reasons for the precipitation of silver particles. — For example, if your colloidal silver generator is producing overly large silver particles, you will often see premature precipitation of the silver particles in your storage container. The more silver-gray residue you see beginning to coat the sides or bottom of your storage container, the weaker in potency your homemade colloidal silver solution is becoming.— Also, it’s important to note that using salt or baking soda or other additives to boost the speed of the colloidal silver-making process will add to the overall size and weight of the silver particles (due to agglomeration of the particles into larger particle clusters). This will ultimately cause your silver particles to precipitate prematurely and begin forming a residue on the sides or bottom of your storage container. Once again, this is a sure sign that your batch of homemade colloidal silver is beginning to lose its potency.   What’s more, if your storage container is exposed to excessive heat or excessive cold or even excessive sunlight or other bright light for prolonged periods of time, then precipitation of the silver particles could begin taking place.   The bottom line is that any time you can see that your silver particles are precipitating our of solution and coating the bottom or sides of your storage container, then it’s time to make a fresh, new batch of colloidal silver. It’s that simple.   ************************************************************************ Inhibition of Candida albicans yeast-hyphal transition and biofilm formation by Solidago virgaurea water extracts.– J Med Microbiol. 2012 Jul;61(Pt 7):1016-22 –Authors: Chevalier M, Medioni E, Prêcheur I Abstract
Xerostomia is a decrease of saliva secretion, which can unbalance the oral microflora, mainly to the benefit of Candida albicans. The aim of the present study was to find a plant extract that could create an unfavourable environment for Candida, and would, therefore, be appropriate for use in a dry-mouth daily-care mouthwash. Water extract from the herbaceous plant Solidago virgaurea (Goldenrod)[U1]  was selected due to its saponin content (plant detergents). Saponin concentrations reached 0.7 and 0.95 mg ml(-1) in S. virgaurea subsp. virgaurea and S. virgaurea subsp. alpestris extracts, respectively. C. albicans was grown in liquid medium and cells were counted by microscopic examination after 0, 4 and 24 h of incubation. Solidago extracts did not inhibit the growth of C. albicans (four strains), Escherichia coli, Pseudomonas aeruginosa, Staphylococcus aureus, Streptococcus mutans, Streptococcus salivarius or Enterococcus faecalis. When inocula were incubated with Solidago extract for 4 and 24 h, we observed a decrease in Candida yeast-hyphal transition.[U2]  Candida biofilms were then prepared in microtitre plates and treated with plant extracts at 0 h, to estimate biofilm formation, or at 18 h to estimate the effect of the saponin on pre-formed biofilms. Biofilm formation and pre-formed biofilms were both strongly inhibited. In conclusion, the S. virgaurea extract was efficient against two key virulence factors of C. albicans: the yeast-hyphal transition phase and biofilm formation.-PMID: 22422572 [PubMed – indexed for MEDLINE] ************************************************************************* Parthenolide, a sesquiterpene lactone, expresses multiple anti-cancer and anti-inflammatory activities. Inflammation. 2012 Apr;35(2):560-5–Authors: Mathema VB, Koh YS, Thakuri BC, Sillanpää M Abstract
Parthenolide, a naturally occurring sesquiterpene lactone derived from feverfew (Tanacetum parthenium), exhibits exceptional anti-cancer and anti-inflammatory properties, making it a prominent candidate for further studies and drug development. In this review, we briefly investigate molecular events and cell-specific activities of this chemical in relation to cytochrome c, nuclear factor kappa-light-chain enhancer of activated B cells (NF-κB), signal transduction and activation of transcription (STAT), reactive oxygen species (ROS), TCP, HDACs, microtubules, and inflammasomes. This paper reports that parthenolide shows strong NF-κB- and STAT-inhibition-mediated transcriptional suppression of pro-apoptotic genes. This compound acts both at the transcriptional level and by direct inhibition of associated kinases (IKK-β). Similarly, this review discusses parthenolide-induced ROS-mediated apoptosis of tumor cells via the intrinsic apoptotic signaling pathway. The unique ability of this compound to not harm normal cells but at the same time induce sensitization to extrinsic as well as intrinsic apoptosis signaling in cancer cells provides an important, novel therapeutic strategy for treatment of cancer and inflammation-related disorders.—PMID: 21603970 [PubMed – indexed for MEDLINE] ****************************************************************************   After-Birth Abortion- Eugenicists Say Babies are a Parasitic Burden on Society   According to Alberto Giubilini and Francesca Minerva, “after-birth abortion” is proposed as a form of “contraception” that would allow babies to be killed after they are born. In a paper published in the Journal of Medical Ethics: “[W]hen circumstances occur after birth such that they would have justified abortion, what we call after-birth abortion should be permissible. [U3] … [W]e propose to call this practice ‘after-birth abortion’, rather than ‘infanticide,’ to emphasize that the moral status of the individual killed is comparable with that of a fetus … rather than to that of a child.–Therefore, we claim that killing a newborn could be ethically permissible in all the circumstances where abortion would be.[U4]  Such circumstances include cases where the newborn has the potential to have an (at least) acceptable life, but the well-being of the family is at risk.”—Giubilini and Minerva believe that infants are a “threat” to parents because of their financial burden to their parents and that this justifies the murder of new-born babies.-In the Senate, Joe Pitts and Chris Smith spoke out against this ideology. Smith explains: “Giubilini and Minerva say the devaluation of new-born babies is inextricably linked to the devaluation of unborn children.”–Ann Furedi of the British Pregnancy Advisory -Board stated that it was of no consequence to define the point when a fetus is subject to legal limitation with regard to abortion rights. Giubilini and Minerva agree with this summation by stating that “merely being human is not in itself a reason for ascribing someone a right to life. Indeed, many humans are not considered subjects of a right to life,” such as “spare embryos where research on embryo stem cells is permitted” or “fetuses where abortion is permitted.”[U5] —By defining personhood as being established “some time” after birth, Giubilini and Minerva assert that a fetus has no claim to personhood, and therefore no right to life. They write that-“[I]n order for a harm to occur, it is necessary that someone is in the condition of experiencing that harm. If a potential person, like a fetus and a newborn, does not become an actual person, like you and us, then there is neither an actual nor a future person who can be harmed, which means that there is no harm at all. … In these cases, since non-persons have no moral rights to life, there are no reasons for banning after-birth abortions. … [U1] —-Indeed, however weak the interests of actual people can be, they will always trump the alleged interest of potential people to become actual ones, because this latter interest amounts to zero.” Giubilini and Minerva support previous arguments for infanticide regardless of whether or not the baby were given a short lifespan due to a medical prognosis.-Simply by being born the baby is regarded as an “unbearable burden on someone, then people should be given the chance of not being forced to do something they cannot afford.”[U2] —Parents, relatives and even society should be enabled to force a mother to submit her child to infanticide because of the benefits that one less person would bring to our world.[U3] —Giubilini and Minerva state that infants are dependent on parents just as fetuses are parasites to the mother’s body. And since no one can ensure that this person will not die prematurely in the future, the investment of resources, time and emotional support cannot be assumed to be a right of the infant.—During pregnancy, the development of the fetus can reveal defects that can legally warrant a partial-birth abortion. Giubilini and Minerva argue that this fact can be extended to after birth because a defective baby can be an “economical, social or psychological” burden because of the energy needed to care for the child.—They say that “people should be given the chance of not being forced to do something they cannot afford.”—The prevention of right to life for infants has another supporter in a study published by the Archives of General Psychiatry (AGP) that asserted pre-mature babies are at an increased risk for bipolar disorder, depression and a wide range of psychosis that would render them a danger to themselves and others later in life[U4] .—Marjorie Wallace, chief executive of a SANE, a mental health charity, stated: “We already knew that premature birth may be linked to schizophrenia, but to see evidence linking it to a range of psychiatric conditions which required hospitalization is striking.”[U5] –While Giubilini and Minerva use eugenics agendas to coerce the public into believing that society would be better off without certain “burdensome” infants, an outright attack on fertility is taking place. —[U6] Dr. Martin Matzuk , professor of molecular biology, molecular and human genetics, and pharmacology at Baylor College of Medicine (BCM), is working on a birth-control pill for men that blocks the proteins essential for sperm production – rendering men “voluntarily” infertile.[U7] –The BCM has a long history of working to expanding the eugenics agenda with the use of genetic technologies; including collaboration with the German Nazis and their march toward using genetics to create a “better human race”.—By looking for “justice as fairness” with the ethical practice of genetics and eugenics concerning applied science and social constructs.—The advantage of eugenics ideology in genetic technology is viewed as “the greatest benefit of individuals with the least advantages.” And so by subverting the fact of eugenics in genetic advances will alleviate prejudice and make sure that the eugenics agenda is devoid of negative perceptions so that the genetically disadvantaged could be touted as the beneficiaries of eugenic applications in genetic technologies.—Last month, the Bill and Melinda Gates Foundation (BMGF) hosted The London Family Planning Summit (LFPS) where the BMGF secured funding for depopulation efforts in Africa, India and the Southeast Asian region. Melinda Gates believes that if she can prevent 40% of people who would otherwise have been born, she could justify her family planning scheme to make women healthier who’s “families are more successful and their communities are more prosperous.”—Simply put: the BMGF has classified “unwanted” pregnancies as justification for killing people and they are focusing on eventually eliminating this number to reduce the world’s population. Africa, a big focus for the BMGF is being targeted along with Muslim nations.—In this propaganda cartoon, the depiction of brown and black women as disfigured potatoes having much more fun because they have fewer children is not only offensive, but telling of how these global Elite view the people they purport to be “saving”.—By preventing births, the film says that 600,000 people would not be born. Contraception as a first step in the global Elite’s plan to depopulation by appearing to help save lives of women could be quite effective.   ********************************************************************************************** Thyme May Be Better for Acne Than Prescription Creams   Thyme. Herbal preparations of thyme could be more effective at treating skin acne than prescription creams, new research suggests. ScienceDaily (Mar. 27, 2012) — Herbal preparations of thyme could be more effective at treating skin acne than prescription creams, according to research recently presented at the Society for General Microbiology’s Spring Conference in Dublin. Further clinical testing could lead to an effective, gentler treatment for the skin condition.—Researchers from Leeds Metropolitan University tested the effect of thyme, marigold and myrrh tinctures on Propionibacterium acnes — the bacterium that causes acne by infecting skin pores and forming spots, which range from white heads through to puss-filled cysts. The group found that while all the preparations were able to kill the bacterium after five minutes exposure, thyme was the most effective of the three. What’s more, they discovered that thyme tincture had a greater antibacterial effect than standard concentrations of benzoyl peroxide — the active ingredient in most anti-acne creams or washes.–Dr Margarita Gomez-Escalada who is leading the research project explained how tinctures are made from plants and herbs. “The plant material is steeped in alcohol for days or even weeks to prepare a tincture. This process draws out the active compounds from the plant. While thyme, marigold and myrrh are common herbal alternatives to standard antibacterial skin washes, this is the first study to demonstrate the effect they have on the bacterium that causes the infection leading to acne,” she said. The researchers used a standard in vitro model that is used to test the effect of different substances applied to the skin. The effects of the tinctures were measured against an alcohol control — proving their antibacterial action was not simply due to the sterilizing effect of the alcohol they are prepared in.—-These initial findings pave the way for more research into the use of tinctures as a treatment for acne. “We now need to carry out further tests in conditions that mimic more closely the skin environment and work out at the molecular level how these tinctures are working. If thyme tincture is proven to be as clinically effective as our findings suggest, it may be a natural alternative to current treatments,” explained Dr Gomez-Escalada.—A herbal treatment for acne would be very welcome news — particularly for acne sufferers who experience skin sensitivity. “The problem with treatments containing benzoyl peroxide is the side-effects they are associated with,” said Dr Gomez-Escalada. “A burning sensation and skin irritation are not uncommon. Herbal preparations are less harsh on the skin due to their anti-inflammatory properties while our results suggest they can be just as, if not more, effective than chemical treatments.” Story Source-The above story is reprinted from materials provided by Society for General Microbiology.   

Posted in Health Politics, Remedies, The Remedy Show notes, Tony Pantellresco's Articles, Uncategorized | Leave a comment

 Tony Pantalleresco Radio show Notes week of September 3rd 2012

The Truth about Antidepressants.-Withdrawal Side Effects

Most Nations in the World Have No GMO-Free Platform To Protect Their Citizens

Individualized Medicine- FDA Approved Ingestible Microchip Tracking Device

In vitro effects of citrus oils against Mycobacterium tuberculosis and non-tuberculous Mycobacteria of clinical importance

Hacking the human brain- researchers demonstrate e
xtraction of sensitive data via brain-computer interface

***********************************************************************
The Truth about Antidepressants.-Withdrawal Side Effects

This is a massive subject, and I am living a very difficult life at this time which is interfering with my writing. So, I have to rough this out. This report is based mainly upon information I gathered during a study of antidepressants I did in 2008/09. This was the study that netted the classified documents from GSK
This is the first section of this report.
I will do this report one section at a time, and the steps will be:
1. Testimonies of people destroyed by antidepressants
2. The chemistry of the various antidpressants, and which dangerous substances in everyday life they deliver directly to the brain – Yes, you heard that right, there are several that do nothing more than deliver modeling glue and other nasty aromatic hydrocarbons straight to your brain, and KEEP THEM THERE. Several would be replaced well by a gasoline inhaler attached to a backpack that you carry with you – (pill form is easier though) and others, like Prozac, are derived from fluoride. Antidepressants deliver a very stable but FILTHY high until you fry, and the hydrocarbon based ones cause exactly the same damage you get from working in a paint booth without a respirator.[U1]  I HAVE PROOF.
3. The visible physical damage antidepressants cause and how and why it occurs, including osteo porosis, calcification of the brain, brain shrinkage, destruction of white matter, corkscrewed axons, liver and other organ damage, and some interesting ancedotes related to this.

4. The motivation for attempting to destroy the entire population of a nation with these substances, and an expose of the corruption in the FDA, the medical community, the Jewish connection, the banker/Rothchild/Rockefeller/facist connection, the future slave state, how the research SSRI’s are based on was done in Russia and imported to America in the form of Prozac, and the proposed finalization of the destruction of Western civilization which “antidepressants” will play a central role in.
5. A detailed exposure of why antidepressants destroy bonding relationships, and make it impossible for anyone to fall permanently in love genuinely, with a little side attachment explaining the reasons for why specific brands destroy sex in different ways. – I actually have the line by line answers for EACH BRAND, and which part of the brain they ruin to often permanently destroy sex in different ways. Different brands destroy different pathways, but all are effective in wrecking sex.
6. How they get away with hurting so many people under the supposed cover of doing good, and the methods put in place to avoid being sued, imprisoned, and hung. What WE need to do to forever expose this scam, and make sure they are sued, imprisoned, and hung. I have the answer to EXACTLY how we can blow this open and hang them.–
Prescribed Deletion – testimonies of the destroyed.
These are the words of those who have been destroyed by antidepressants. If you are among them, STOP listening to your P-doc telling you it never happens; the reality is that they ALL know it happens and they are lying to you. View this chart, and READ THE RESULTS THAT FOLLOW.
These are testimonies of people destroyed by antidepressants.
– – – – – –
“Whoever said that they lost most their ability to love; MAN, that is the thing I miss the most. I was a very, very, very passionate person prior to celexa. I was passionate about everything, my marriage, my job, my country. I couldn’t hear our national anthem without stopping and feeling the hairs on the back of my neck stand straight up. 14 years in the Army National guard, I was very into my career with them too. I was passionate about running, about my relationship with (and this will probably sound wierd) my dog. I miss all of these things. I hope they all come back to me. They were very much the bricks in the foundation of my life and I feel like they are gone. When I say I want the old me back, I mean the person who was passionate, the person who loved and was loved. The driven person who saw what he wanted and went out and got it. That was all taken from me with the introduction of Celexa in my life. I just want it back.”
– – – – – –
“I’ve been in an extremely peculiar state for the past 8 months after stopping Wellbutrin/buproprion. I have literally lost everything inside of me and no longer have a sense of “inner being”. My personality has been completely erased, along with the inner psyche I’ve spent a lifetime building. When I attempt to “look inside”, it is impossible because there is literally nothing there. Everything that made up my specific sense of personal being is gone,  including my hopes, fears, dreams, goals, opinions, values, morals, likes/dislikes, and most strikingly, all emotions and feelings.—I have no feelings associated with past events, and no emotional connections with anything in the world. Specific emotions that defined my personal sense of being are no longer there. People, places, things and events that I thought were etched in my soul as having significance no longer mean a thing. Absolutely nothing, I can’t stress this enough.–I am unable to look backward or forward, have no sense of past accomplishments and no desire for future ones. The strangest thing is, I cannot feel anything toward being in this state, as that part of me is gone too. It’s like a recursive erasure of everything I ever was, am, and will be.–It doesn’t feel like life is a conscious experience that I am having anymore, as there is no inner construct within me to absorb an experience on any level. I see, hear, touch, and smell, yet each of these is so devoid of emotional content that they don’t coalesce into anything meaningful I can call a human consciousness. My sense of being has been replaced by a constant void of nothingness that is unchanging, 24/7, I feel nothing towards the nothingness. It is not like feeling empty inside, there is no inside to feel empty within.—Getting to this state was a long process that started with gradually losing my emotions. This started when I decided to withdraw from the antidepressant Wellbutrin/Bupropion which I’d been on a high dosage of for 5 years. Strangely, going back on it did not help, but made things worse. When I stopped and started the drug a second time, I experienced one tremendous day of improvement followed by a seizure while sleeping, and woke up in a confused state. After this I regressed and felt completely dead inside.–This waking up in a confused state happened 2 more times, once in May 2010 and once in September 2010. Both of these were preceded by sudden improvements. But upon waking I felt like I had lost a basic part of my self. Not just feelings, but the core of my being. What I felt to be the complete and final destruction of my inner being happened on September 7th, 2010, and there hasn’t been a change since (it has now been 8 months).—“I tell you, I never had a problem before celexa. I just want to be back to me. I want to no longer be the pitiful creature it made me. I want to be me. The old me. I want myself back. Life isn’t worth living with this new person holding my thoughts and feelings hostage. I have been off Celexa since last year. I JUST WANT ME BACK.”—“I have been on 0 mgs for almost a year, and my emotional state has yet to come back to normal. (normal me). I have been from Psyc doc to Psyc doc (never needed before celexa) to try to figure it out. They point the problem back to me. I found out by reading around the Internet, and buying the book “Prozac: Panacea or Pandora” by doctor Ann Blake Tracy, and I found out that several people, if not all people, who go off these drugs experience exactly what I have experienced. When Natalie wrote what she wrote, you can go back to some of my earlier posts and the withdrawal effects are written down almost verbatim. These are bad for our brains, they change our personalities. I want my life back, and don’t want even my worst enemy to experience what I have been through. These people have no love for their fellow man[U2] . We need to, no matter how emotionally messed up we are, we need to band together and prevent them (a commercial for Cymbalta just came on the tv, made my blood boil) from prescribing them to ANYONE. Depression hurts said the commercial, I never knew depression till after celexa. I have been through hell, therefore hell exists.”
– – – – – –
“What I don’t understand is how a drug could completely erase me as a human being. What I’m experiencing is not depression, anhedonia, or flat affect, but a permanent change in my consciousness that literally destroyed my humanity. All the parts that made up my being are literally gone. I don’t understand how this is even possible, or what (if anything) I can do to change it.”
– – – – – –
“I’m 25 yrs old. I used to be a bodybuilder, avid fisherman, used to drag race, and enjoy the great outdoors. USED TO. I was on effexor for about 3 yrs, 75mgs. I decided I wanted to stop taking it, I felt fine. Im 25 I said and I can deal with lifes problems. I told my doc if I may discontinue the drug he said sure, if you want to. Doctor didn’t even ask me if I wanted to wean off, I suggested him to give me the 35mgs, but he gave me only a weeks worth. I have never in life felt so sick. I would not wish this on anyone, not even my enemy. The first 3 months were hell. dizziness, nausea, fatigue, bad memory, brain zaps, you name it I had it. I couldnt even walk sometimes. I fought and fought and it is now 7 months that I am clean off this horrible so called drug. To this day, 7 MONTHS later, I am left with weakness, bad memory, and horrible coordination. I can no longer workout, all my muscles went down, I have no energy to do what I liked to do in my life. I cannot function or remember things at work. I am useless. If it wasn’t my cousins place, I would have been fired along time ago. I am not depressed, I don’t have panic attacks. In my opinion, Effexor has left me permanent damage. I have been through more tests than you can think of. blood tests upon blood tests for every disease known to man. This drug has changed my life for the worse and everynight i cry, because I feel that this medicine has severly left me damaged. My doctor has no idea what to do[U3] .”
– – – – – –
“I was prescribed Zoloft 25-50mgs 9 years ago while I was in college.
Before I begin with the nightmare, let me stress I WAS NOT SICK when I started this drug. I had anxiety (situational )and was a little tired. That is it. Other than these issues, I was as healthy as a horse, never been in the hospital, rarely if ever needed to go to the doctor. I was very active and on the go. Well, Zoloft worked immediately, what can I say. I loved it. Loved it loved it loved it. I thought it was a gift from God, saved me and my college career. I wasn’t as shy as I had been. I felt more social. But then I found I could not get off without severe head pain and brain zaps. So, I stayed on it. Every few months I would think about going off again, but the symptoms I would get kept me on it, and very afraid to come off. So, I stayed on it for 8 long years. (I forgot to mention I gained 25 pounds within the first 3 months on it. That was another reason I wanted off). After 8 years, I’d had enough. I felt like I no longer needed it, I had been long out of college and the original situations that gave me anxiety were long gone. So, at my doctors advice, I tapered over about 3-4 weeks. Then my life was shattered. Completely shattered. I was told the withdrawal would only last a week or two at most, so I rode it out. It never went away and only kept getting worse. So, I gave up and tried to go back on. I couldn’t take the symptoms anymore. But my body was having none of that. Strangely, now when I took Zoloft, my body and brain reacted badly, as if it were rejecting it. I got a fever and felt like I was dying. I had no choice but to get off again. I was given other SSRI’s, but none of them helped either, and all of them made me worse. I no longer tolerated meds like I did prior to Zoloft. I kid you not, here I am 3 YEARS later and still very ill, and it all began when getting off Zoloft. Here is what I suffer 24/7….. severe head pain and pressure brain zaps/ electrical zaps shooting through brain down to toes burning in extremities and brain severe fatigue and weakness dizziness/vertigo severe depression ( never was depressed, ever, until coming off Zoloft ) severe anxiety panic attacks…BAAAAD daily crying jags skin eruptions and bone and muscle pain burning tongue insomnia
digestive pain cramping on right side under rib cage hair loss
sensitivities to food and medications previously tolerated well
extremely sensitive to vitamins and minerals previously tolerated well no motivation / severe apathy loss of career and income/ on disability derealization/ depersonalization back and neck spasms unable to drive, shop, or eat out increased allergies to things once tolerated well ( smoke, dust, cats ) suicidal thoughts….pretty regularly and very scary nightmares jaw pain from clenching teeth ( I guess from severe stress ) agoraphobia…very heartbreaking since I used to be so busy ears ringing feeling like being hit it the back of the head with a shovel pressure in chest, like a 100 elephants are sitting on me racing pulse, even when resting increased blood pressure and cholesterol metallic taste bladder spasms loss of cognition/ mental function ( feels like I lost 50 IQ points ) difficulty concentrating and recalling facts I wrote a letter to Pfizer, detailing my story and my symptoms. They blew me off and wanted a doctors opinion of what my illness is from. No doctor will admit to Zoloft being the cause of this illness, so Pfizer pretty much told me they take no responsibility. They ruined my life, and take no responsibility. They train their drug reps to educate doctors that these drugs are harmless. They know better, but rake in too much money to do anything about it. They do not care how many lives they destroy, as long as they continue making their billions off innocent victims.”
– – – – – –
“My withdrawal from Seroxat/Paxil (a few years ago, now). I became very aggressive on the stuff (many arrests and court appearances), and on some days I could pop valium like smarties without it making the slightest bit of difference. When I decided it would be a clever move to stop taking it and put up with a few days of flu-like symptoms, I found out what withdrawal was really like. I slashed at my arms, I rolled around on the floor, screaming, because everything felt raw (my theory is that we ‘normally’ perceive the world through a comfortable haze of endorphins–which was stripped away) and when the police were called I freaked out completely and brandished a knife at them. My husband referred to that state as being ‘animalistic’. Needless to say, I escaped jail by a hair’s breadth. When I ended up in ER, following a dose of pepper spray in my face, I begged for Seroxat and the doc just laughed in my face and said they weren’t running a pharmacy. They did not believe there was such a thing as SSRI/SNRI withdrawal syndrome. I think they still don’t. In the cell, waiting for the court appearance, I had the worst shakes and weird feelings (derealisation, having two heads, having my head swell to the size of a water melon). The junky I shared the cell with said: “Wow, what are you on?”
– – – – – –
“Please consider this before commenting on antidepressants in a positive way.
About 10 years ago, the medical school at a major university began to notice a large number of cadavers coming in (for the medical students to work on) which had indented and calcified frontal lobes in their brains. Puzzled by this, they went through the life history of each cadaver that had this anomaly, and discovered that in every case, the person had been on SSRI antidepressants. The level of brain damage indicated that each of the cadavers had been lobotomized. The people who drew the connection between the calcified and collapsed frontal lobes (the part of the brain which contains your soul) and antidepressants received offers of money to keep it secret, and when they chose to go public anyway, received anonymous death threats against their families and children if they ever went public. –I have seen many people get destroyed by antidepressants, all the while they said all was well. Invariably they go down the toilet as they eventually move toward complete and total emotional and personality flatline.”
– – – – – –
“I am on my 7th day of no Cymbalta after being on it for only 3 weeks. I went from 60mg to 30mg, no problem. Then 30mg to 15mg, by making my own pills from the 30mg. Brain Zaps started. Now since I am clean for 7 days the Brain Zaps are hell,[U4]  I think I even blink when they hit me. Inside my head the Zaps sound like a chattering angry squirrel. The people that made this drug must have never tested it for withdrawals. I have terrible back pain, have trouble sleeping, and have even cried twice this week. I just took 50mg of benedryl and 1000mg of tylenol hoping I can sleep tonight. I also gained weight on the drug. Has anyone that dealt with the Brain Zaps stopped having them all together? They are so bad, I am afraid to drive, I now understand why some folks kill themselves coming off drugs like this one. If there is a happy ending, I would love to know about it. Almost forgot, Blood Pressure has gone thru the roof coming off this stuff.”
– – – – – –
“I will name the countless symptoms and probably unreversable brain damage I am living with after Effexor. There are good days in which some of the symptoms won’t arise for exception of the pain. Those are the days I can be a mother and wife but still the shadow of the energetic person I was. Back in July all the symptoms hit me all at once. Blury vision, dizzy, letargic, high pitch ringing in my ears, exhaustion, pain all over my body, joints and muscles. Muscle twitching, slurred speech, urinary incontinence at times, hair lose in patches. It is impossible for me to normally work at any type of job now. I have states where I would forget what I am doing. I have times in which I have a hard time controlling voluntary motor functions in my legs and arms (such as not being able to write, open a bottle or carry anything). Every now and then muscles will begin to twitch, then just stop, out of the blue. I became lethargic and have no energy to do anything. Not to mention times or days when I can not drive due to the chance that I would have an accident beacuse of the sudden blury vision or dizzines that make it dificult to see. Not to mention when I suddenly forget where I am going or doing.”

– – – – – –
“I have been on Celexa for almost three years. the results: lost a job and a marriage due to being so non complacent but gained 20 lbs. I skipped a few doses several weeks ago and decided it was time to wean myself off. I tapered down very quickly and am now dealing with the following withdrawal symptoms:
Anxiety
Dizziness
Fatigue
Headache
Insomnia
Diarrhea
Nausea
Restlessness
Blurred vision
Jolting electric “zaps” (at bedtime)
Tingling sensations
Abdominal discomfort
Flu symptoms and general malaise
agitation
Vertigo
Gait disturbances
Sweating
Irritability
Aggression
Sleep disturbance and insomnia
Nightmares
Vivid dreams
Confusion
Memory and concentration difficulties
Crying spells
Lethargy
Weakness
The aggression is the scariest part but now that I know almost everyone experiences this I feel better. From reading most of the posts it doesn’t seem to matter if you wean yourself or go cold turkey, the withdrawal symptoms appear the same.”
– – – – – –
I believe SSRIs “cause” neurogenesis through the brains compensatory mechanisms. By inducing a massive chemical imbalance at the synaptic level, SSRIs force the brain to respond by shutting down these connections and creating new ones (which then get shut down, and the cycle continues). Unfortunately, these new connections (axons) often resemble the type of new axonal growth (swollen/corksrew appearance) seen after recovery from a neurotoxic MDMA regimen. (editor’s note – MDMA is Ecstacy) These axons also often grow and/or project into areas where they did not before, and the significance of this is as of yet unknown.
7. The most troubling permanent lasting adverse neurological effects you may experience after prolonged SSRI usage (and consequent STOPPING) are :
a). Word finding troubles
b). Absolute emotional flatness and deadness
c). Permanently reduced sex drive
d). An odd, pervasive social anxiety/awkwardness
e). Trouble with coordination
f). Bad memory
g). Trouble retrieving words
h). Overall paucity of thought and expression
i). Lack of creativity and intellectual fluidity (mental fog)
j). A lack of ability to “steer” or control the tone of your voice
(I’ve noticed this- that I sound shaky and agitated no matter what my
mood is, and people think I’m upset when I’m really not)
8. After these brain damaging effects have sunken in, you may have great difficulty finding support anywhere. Talking to a p-doc may be an exercise in futility. They will want to protect their own interests and shield themselves from a possible lawsuit, hence you may be told continually to get back on meds/up your dosage. The more you protest, the less credibility you have, thus the more evidence in your p-doc’s mind that you need to go back on SSRIs.[U5]
9. Once you realize the extent of the damage, and it sinks in beyond the denial you may initially face, it will be hard to explain to others exactly why you are not the same person you used to be. The damage is similar to a TBI (Traumatic Brain Injury) yet it might be better termed DBI (Diffuse Brain Injury).
– – – – – –
Cymbalta
“Oh, how the withdrawal wrecked me. The only thing worse than taking Cymbalta was withdrawal from Cymbalta. Added to all the side effects I was already having, I very much wanted to cut myself, and got as far as sitting down with a blade, but instead I bit myself on the hand as hard as I could stand. I think I also punched myself in the thigh that same day, but it’s all sort of hazy. The first day off Cymbalta, I hallucinated, felt like my arms were really far away from the rest of my body, dissociated for most of the day, and in general, thought I was going to have to call for an ambulance. A benzo would’ve really helped, but I didn’t have a pdoc yet at the time; I had to wait three weeks and let me tell you, those were three of the most hellish weeks of my life, including feeling very much like I was having a mixed episode. Out of desperation, I took diphenhydramine because it helped the vertigo and the sleepy feeling sort of passed for “calmer.” It took at least three weeks for the withdrawal symptoms to calm down to a dull roar. When I saw my new pdoc, I was still agitated.”
– – – – – –
Your doctor is your worst enemy. Welbutrin is an SNRI. It blocks the metabolites in the liver that metablilze seretonin and noepinephrin. Switching to celexa, which is an SNRI is not going to help you. Doctors just have no clue as to what they are doing. You go to them with a problem, they consult ther PDR, and hand out some drugs that the pretty little pharma rep gave to them. They will give you something to destroy your brain, then give you a benzo like xanax, to combat anxiety. You cannot sleep, you are always on edge, you end up with some sort of psycological “disorder” (manufactured by the drug companies), and you are left a buned out shell of what you used to be. They tried to give my mother-in-law prozac because she was sad when her father was dying of cancer, and she was starting to go through menopause. I SCREAMED. This lady didn’t need prozac, or any other mind altering drugs. She needed to reduce her stress.
I told her to take topical progesterone, and she turned around just fine.
Fact: Doctors don’t know what ssri’s do to the brain
Fact: There is no evidence of a lack of neuro transmitters.
Fact: There is no way of measuring the level of seretonin in the brain…
I pray for anyone in distress anywhere, and God bless and help those whose lives were destroyed by doctors who dished out meds that they know nothing about.
——–
WITHDRAWAL
did anyone else get tapered off zoloft from a doctor but still having withdrawal?
this is how my doctor did it and I am still trying to understand why it was just down to 50mg and not less after a while: starting with my 100 mg
week 1- 50 mg every day
week 2 and 3 50 mg every other day
week 4 50 mg every two days
week 5 50 mg every three days
week 6 off (on this week now)
I took my last on sunday and it’s now Wednesday. last night I could not sleep, I felt very cold and I was shivering and had interrupted sleep and then got too hot all over like I was burning. I’ve had the brain zaps all along on the days I didn’t take it and some of the shivering and feeling a little dizzy too , very restless sleep on and off for these last few weeks. also some irritability, and very depressed and hopeless feelings and anger, some crying spells for no reason. I don’t want to call the doctor because obviously they don’t know what they are doing or I wouldn’t have withdrawl symptoms at all.
– – – – – –
My daughter began having petit mal seizures. Coincidentally, she was just recently placed on zoloft. I am sure it was only a coincidence, right? What did zoloft do to you?
– – – – – –
YES, ZOLOFT IS EVIL. IT RUINED MY LIFE. IT MADE ME ACT TOTALLY OUT OF CHARACTER AND I MAIMED MYSELF IN AN INDESCRIBABLE WAY.
– – – – – –
Zoloft destroyed my life, and my Dr. and therapist stood by and watched it all happen right before their eyes, it was like I was a project for them. I am sorry to those I affected during that time, I regret it everyday.
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Most Nations in the World Have No GMO-Free Platform To Protect Their Citizens

Unless you live in the dozen or so nations in the world who have declared GMO (genetically modified organism) bans, then you’re likely eating GMO. Eating organic is your best chance of avoiding GM foods, but it’s almost impossible to avoid them entirely, especially if you’re living in a country that doesn’t restrict their cultivation, import or export. The United States, Canada, China, UK, Australia, Mexico, and most of South America, Asia and Africa have no formal GMO-free platforms and their use is typically unrestricted and widespread. Nations with no formal GMO-Free platform (in red). Nations with laws restricting GMO in most areas (in yellow), and nations who are either GMO-free or have declared national bans (green).
Click for larger image

The image above is a shocking reminder of how we have allowed biotech industries to take over our planet. It is my dream to one day see this image turn from the majority red to green. Countries represented in red have no enforced national laws banning GMOs, their import, export or cultivation. Most of these nations have a very large percentage of their citizens eating GM foods.

NORTH AMERICA
The United States is the leader in GM cultivation and now grows mostly GM varieties of corn, canola and soy. Hawaii now grows GM papayas. Approvals have also been given for GM alfalfa, zucchinis, beet sugar and tomato varieties, though not all are currently being grown. In 2010, the US planted 66.8 million hectares of soybean, maize, cotton, canola, squash, papaya, alfalfa and sugarbeet. The largest share of the GMO crops planted globally are owned by Monsanto.

More than 30 of Monsanto’s directors, CEOs, VPs, board members, managers, scientists, attorneys and consultants also hold Federal Positions within the US government.

Canada has widespread GM crop usage. All Canadian canola is GM, as is a large portion of the country’s soy and corn. Prince Edward Island tried to pass a ban on GMO cultivation but failed, and GM crops in the region are currently increasing.

Despite the fact that 233 consumer and farmer groups in 26 countries have joined the “Definitive Global Rejection of GM Wheat”, Canadian MPs voted to reject stronger export rules for crops of genetically modified organisms (GMOs).[U6]

SOUTH AMERICA
Even though GMO continue to face strong resistance in South America, it is widespread. One third of the 134 million hectares of Genetically Modified Organisms (GMO) planted globally in 2009, were in South America. Brazil and Argentina are the main producers, with 21.4 and 21.3 million hectares respectively. Of all the countries in the world that are planting genetically modified crops, seven are in South America. They include Argentina, Bolivia, Brazil, Chile, Columbia, Paraguay and Uruguay. There are also no national restrictions in Guyana, Suriname and French Guiana to the north of the continent. Between 2008 and 2009, world production of GM crops increased eight percent, while in Brazil it rose 35 percent.[U7]

Peru, Ecuador and Venezuela have all declared national bans on GM foods. Peru officially passed a law banning genetically modified ingredients anywhere within the country for a full decade before coming up for another review. In 2008 Ecuador declared the country GMO free and will limit its biotechnology. In 2006, Venezuela banned genetically engineered crops thanks to President Hugo Chavez Frias.[U8]

MEXICO
In January 2010, Slow Food Tehuacan Mixteca Popoloca convivium launched a campaign to protect traditional varieties of maize after the Mexican government gave the go ahead for the first legal plantings of GM corn following a decade-long battle. The convivium is concerned that modified genes could spread and contaminate genetically valuable native varieties and is working to educate family and farmer organizations about the richness of their country’s biodiversity, encouraging the Mexican community to be proud of their cultural heritage and to work for its revitalization. Mexico does not have any GMO-free zones.
EUROPE
Europe is quickly becoming the most progressive continent in the world to oppose GM foods. France, Italy, Switzerland, Hungary, Bosnia, Serbia, Croatia, Latvia and Albania have all declared many regions to be GMO-free. France made an important step in the no-GMO movement by specifically defining exactly what “GMO-free” means when it comes to food labeling[U9] . Spain and Portugal are slowing advancing but they have a long way to go before declaring most of their regions GMO-free. Britain officially supports GM crops and has trials of GMOs like potatoes planted. Austria, Greece and Poland are now completely GMO-free zones thanks to public and government support.

AFRICA
Egypt and Madagascar are the only two countries in Africa to ban GMO. Any agricultural imports to Egypt must have a certificate from the country of origin that the product is not genetically modified and the rule will also apply to Egyptian exports. Madagascar banned growing or importing GMO foods due to concerns over the effect on human health and environment. In Algeria both the planting and distribution of GMO foods is illegal although import laws are lax. Other countries such as Kenya, Lesotho, Ethiopia, Angola, Malawai, Mozambique and Zimbabwe have some limited restrictions in place to ban GMO imports but with many exceptions and critics claim most of the laws are not enforced.

RUSSIA
Russia remains GMO-free. According to the official information there is no growing of GMOs in Russia for commercial purposes. So far the Federal Environmental Assessment Commission has not adopted any commercialized GM varieties for agricultural use.[U10]
ASIA
India has widespread GM cotton use. The widespread planting of Monsanto’s GM cotton has led to tragedy throughout India. The Indian government even banned conventional seeds from many government seed banks in an attempt to please Monsanto (in return, the country was given International Monetary Fund loans to help its economy) and slow the nation’s poverty rates[U11] . An estimated 1,000 farmers commit suicide each month in the country as a result of the crop failure and debt caused by planting the GM seeds.[U12]  Farmers were convinced to spend what was often 1,000 times the cost of conventional seed on the “magic seeds” after listening to Monsanto’s promises of increased yields and resistance to pests. Despite the promises, the crops were often destroyed by bollworms. In addition, the farmers weren’t warned that the crops would require twice as much water as conventional cotton, leading to many crops drying up and dying. The “terminator” seeds also must be purchased again every year. For farmers used to saving seed from year to year, this was often a final financial blow that led to insurmountable debt.[U13]

With the exception of Thailand and Sri Lanka who both have GMO-free zones, all of Asia remains resistant to adopting laws to restrict imports, exports and cultivation of GMO.

NORDIC COUNTRIES
During the meeting of Nordic countries at Terra Madre 2010, delegates from Sapmi, Sweden, Finland, Denmark, Norway, Faroe Islands, Greenland and Iceland discussed a statement that would describe their united position on GMOs. The result was a declaration against GMOs that the convivium leaders, members and food communities could use to lobby against the introduction of these crops, presenting it to their governments and others. Iceland has declared two GMO-free regions in the country.
AUSTRALIA and NEW ZEALAND
All genetically modified foods intended for sale in Australia and New Zealand must undergo a safety evaluation by Food Standards Australia New Zealand, however there are no national GMO bans in either country. However there are regional bans. Tasmania’s ban on the release of GM organisms to the environment will continue until 2014. South Australia has reaffirmed their commitment to ban all commercial GM crops until 2014.
The status of GM crops is constantly changing, both in the United States and around the world. Public outcry is rising against these largely untested foods and crops. The industry claims of “super yields” and an end to poverty and famine have proven to be dangerously inaccurate. Now, more than ever, is the time when our voices (and purchases) can make a real difference. It’s time to support labeling initiatives which may kickstart global campaigns to slowly change our red planet to green and ban GM foods once and for all.
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Individualized Medicine: FDA Approved Ingestible Microchip Tracking Device
Articles Health — 05 August 2012

The Food and Drug Administration has approved an ingestible digital senor that can track physical health with the assertion that patients are not taking their medication regularly and need a tracking device inside their body to assist them in their medical care. [U14] The mainstream medical industry has a term for this new type of spying: individualized medicine.—Proteus Digital Health (PDH) released the Ingestion Event Marker (IEM) which was first approved in Europe. George Savage, co-founder and chief medical officer at PDH claims that this ushers in a new era of digital medicine that “shifts the paradigm.”–The IEM, as small as a grain of sand, can be embedded in a pill, and ingested to monitor the patient and their bodily health. The device will collect measurements such as heart rate, body position and activity.[U15]  The IEM sends a signal to your smartphone; which then transmits the data to your doctor. Actual real time data about your biological make-up can be uploaded wirelessly.—Eric Topol, geneticist and cardiologist, is a professor of genomics at the globalist funded Scripps Research Institute, happily says: “The FDA validation represents a major milestone in digital medicine.—Directly digitizing pills, for the first time, in conjunction with our wireless infrastructure, may prove to be the new standard for influencing medication adherence and significantly aid chronic disease management.”—The transhumanists at 2045 Initiative support the IEM. They are a group of Russian scientists who are working toward the “realization of the possibility of a radical extension of human life by means of cybernetic technology” with the directed point of blending humanity with a “new culture”[U16]  based on science.—By working with international scientists, they are exploring anthropomorphic robotics (the integration of man and machine) while modeling living systems and brain functions with artificial carriers to achieve cybernetic immortality.[U17] —The Elite are researching the possibility that become immortal may mean joining their minds with computers to be able to live forever.—The US government, always looking for new ways to manipulate, has been pouring funds into implantable microchips that could monitor soldiers and the battlefield conditions effect on their bodies.–Through brain implants , ingested in an aspirin, the electrodes “listen” to brain activity and sometimes stimulate activity to “inspire” an action or emotion.  By tuning into the activity of the human brain by monitoring neurons the scientists can decipher thoughts and implant suggestions with ease.[U18] –At the Duke Neurogenetics department in Duke University Medical Center, undergraduate students are conducting experiments to gather information on people through brain scans, psychological tests and genetic markers. This study is led by Professor Ahmed Hariri, hopes to unlock the mysteries of a person’s innate propensity toward anxiety, alcoholism, and other defining psychological traits.[U19]  The drug corporations are currently developing pharmacological substitutes to block and break people’s addictive propensities as aids to psychological treatments. The goal is to create a comprehensive genetic test for the mind.—As pharmaceutical corporations turn their attention toward manufacturing bio-electronics , conventional medicine is being phased out. [U20] Treatment will consist of electrical signaling, monitoring of the body by implants that can transmit massive amounts of data, both physical and neurological, but also administer drugs without the necessity of the patient being involved. Basically, you will not need to swallow a pill; the pill will be administered to you by an implanted electronic device. -Millions and millions of dollars are being spent to move our healthcare toward microchip implants that also control your brain in the name of curing neurological diseases in an endless barrage of technology that could quite simply change the way we think.—Epilepsy, diabetes, and obesity can be controlled by the globalist healthcare system with the “electronic impulses in the brain rather than pills or injections.” Electrical signals will control organ function (or failure) under the cover of less necessity for surgery or pill dependence.—Under the thumb of GlaxoSmithKline, head researcher Moncer Slaouni states the “challenge is to integrate the work – in brain-computer interfaces, materials science, nanotechnology, micro-power generation[U21]  – to provide therapeutic benefit.”—In laboratory tests, rats have responded according to plan; showing that the neural microchip implant transferred information to the rat’s brain. When damaged, the microchip enabled the rat to perform functions that they could not do without the implant.—Intel has produced microchips that will collaborate with the human brain with computers and cell phones by 2020. By harnessing brainwaves a computer, keyboard, television and cell phones can be controlled and operated.—Computer giant IBM has researchers studying how the brainwaves adjust to the frequency of the electronic device within their vicinity to prefect the science of bioinformatics that will read brain activity in analyzing facial recognition, facial emotional responses and thought patterns for the “benefit” of technology.
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In vitro effects of citrus oils against Mycobacterium tuberculosis and non-tuberculous Mycobacteria of clinical importance.
J Environ Sci Health B. 2012;47(7):736-41
Authors: Crandall PG, Ricke SC, O’Bryan CA, Parrish NM
Abstract
We evaluated the in vitro activity of citrus oils against Mycobacterium tuberculosis and other non-tuberculous Mycobacterium species. Citrus essential oils were tested against a variety of Mycobacterium species and strains using the BACTEC radiometric growth system. Cold pressed terpeneless Valencia oil (CPT) was further tested using the Wayne model of in vitro latency. Exposure of M. tuberculosis and M. bovis BCG to 0.025 % cold pressed terpeneless Valencia orange oil (CPT) resulted in a 3-log decrease in viable counts versus corresponding controls. Inhibition of various clinical isolates of the M. avium complex and M. abscessus ranged from 2.5 to 5.2-logs. Some species/strains were completely inhibited in the presence of CPT including one isolate each of the following: the M. avium complex, M. chelonae and M. avium subsp. paratuberculosis. CPT also inhibited the growth of BCG more than 99 % in an in vitro model of latency which mimics anaerobic dormancy thought to occur in vivo. The activity of CPT against drug-resistant strains of the M. avium complex and M. abscessus suggest that the mechanism of action for CPT is different than that of currently available drugs. Inhibition of latently adapted bacilli offers promise for treatment of latent infections of MTB. These results suggest that the antimycobacterial properties of CPT warrant further study to elucidate the specific mechanism of action and clarify the spectrum of activity.–PMID: 22560037 [PubMed – indexed for MEDLINE]
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Hacking the human brain- researchers demonstrate extraction of sensitive data via brain-computer interface
As hard as it is to believe, what many might think is the last bastion of total privacy, namely, the human mind, is quickly becoming just as vulnerable as the rest of our lives with the invention of mind-reading helmets and other ways to “hack” the mind.—Now security researchers from the University of California, Berkeley, the University of Oxford and the University of Geneva, have created a custom program to interface with brain-computer interface (BCI) devices and steal personal information from unsuspecting victims.
The researchers targeted consumer-grade BCI devices due to the fact that they are quickly gaining popularity in a wide variety of applications including hands-free computer interfacing, video games and biometric feedback programs.—Furthermore, there are now application marketplaces – similar to the ones popularized by Apple and the Android platform – which rely on an API to collect data from the BCI device.—Unfortunately with all new technology comes new risks and until now, “The security risks involved in using consumer-grade BCI devices have never been studied and the impact of malicious software with access to the device is unexplored,” according to a press release.—The individuals involved with this project – which resulted in a research paper entitled “On the Feasibility of Side-Channel Attacks with Brain-Computer Interfaces,” include Ivan Martinovic and Tomas Ros of the Universities of Oxford and Geneva, respectively, along with Doug Davies, Mario Frank, Daniele Perito, and Dawn Song, all of the University of California, Berkeley.—The findings of these innovative researchers are nothing short of disturbing. They found “that this upcoming technology could be turned against users to reveal their private and secret information.” Indeed, they used relatively cheap BCI devices based on electroencephalography (EEG) in order to demonstrate the feasibility of surprisingly simple and effective attacks.–The information that can be gained by the attacks is incredibly sensitive, including, “bank cards, PIN numbers, area of living, the knowledge of the known persons.”–Most troubling is the fact that this represents “the first attempt to study the security implications of consumer-grade BCI devices,” which makes the success of the attacks that much more disconcerting. The researchers tested out their proprietary program on 28 different participants who, while they were obviously aware that they were cooperating in a study, were not aware that they were being “brain-hacked,” as it were.—Unfortunately, or fortunately depending on your perspective, the researchers found “that the entropy of the private information is decreased on the average by approximately 15% – 40% compared to random guessing attacks.”–Or as Sebastian Anthony put it in writing for ExtremeTech, “in general the experiments had a 10 to 40% chance of success of obtaining useful information.” The researchers leveraged a distinctive EEG signal pattern known as the P300 response. This brainwave pattern typically occurs when the subject recognizes something such as a friend’s face or a tool necessary to complete a given task.—Using the knowledge of the P300 response, the researchers created a program which utilizes a technique which those who are familiar with typical hacking might call a “brute force” method.–However, this method is only loosely comparable to the traditional brute force methods since we’re talking about using a brute force attack on the human mind.–The researchers did this by flashing pictures of maps, banks, PINs, etc. while monitoring the subject for any P300 responses.–After they had collected enough data from the subject, they were able to easily compare the captured information in order to see when a P300 response was triggered by a certain image.—
Thus, this allowed the researchers to discover with surprising accuracy which bank the subject uses, where they live, and other information which could potentially be highly sensitive.–The key to capturing this information seems to be making the subject remain unaware of the fact that they are being attacked either through specially formulated “games” designed to steal personal information from the mind of the target or through a false sense of security engendered by social engineering techniques[U22] .—Personally, I find it quite troubling that people could have their personal information stolen simply by playing what they think is a normal game controlled by a BCI device when in reality it is a carefully engineered piece of software designed to pull private data from the target’s mind. As Anthony correctly points out, “Moving forward, this brain hack can only improve in efficacy as BCIs become cheaper, more accurate, and thus more extensively used. ”However, Anthony incorrectly states, “Really, your only defense is to not think about the topic,” when in reality the P300 response can occur without consciously “thinking” about the topic.–The response can occur when a picture of a familiar face or location shows up, even if the individual isn’t thinking about the familiar person or the location. While someone could theoretically be on the defensive in an attempt to minimize their responses, the entire methodology of the hacker depends on avoiding detection to begin with. Therefore, if the target is already consciously on the defensive, the hacker has failed in their task of remaining in the shadows and carrying out the attack without the knowledge of the target.—That being said, if programs are created in a clever enough manner, I seriously doubt that most people would be able to tell that they’re being actively attacked in order to obtain their most private and sensitive information.

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Tony Pantalleresco – Show of the Month July 9 2012

Final frontier of climate policy – remake humans

IF IT is so hard to change the climate to suit humans, why not alter humans to suit the changing climate, philosophers from Oxford and New York universities are asking.—They suggest humans could be modified to be smaller, dislike eating meat, have fewer children and be more willing to co-operate with social goals.[U1] Behavioural changes might not be enough to prevent climate change even if they were widely adopted, and international agreements for measures such as emissions trading are proving elusive, say Matthew Liao of New York University and Anders Sandberg and Rebecca Roache of Oxford University.—So human engineering deserves serious consideration in the debate about how to solve climate change, they write in a coming paper for the academic journal Ethics, Policy & Environment.–A person’s ecological footprint is directly correlated to size, because larger people eat more than lighter people, their cars need more fuel to carry them and they wear out shoes, carpets and furniture sooner than lighter people, the authors write. They suggest hormone treatments could be used to suppress child growth, or embryos could be selected for smaller size.–Reducing consumption of red meat could have significant environmental benefits, the paper says, citing estimates that as much as 51 per cent of the world’s greenhouse gas emissions come from livestock farming. They say people who lack the motivation or willpower to give up eating meat could be helped by ”meat patches” on their skin to deliver hormones to stimulate their immune system against common bovine proteins.-”Eating ‘eco-unfriendly’ food would induce unpleasant experiences,” the authors say.[U2] –Better educated women have fewer children, so human engineering to improve cognition could reduce fertility as ”a positive side effect from the point of view of tackling climate change”, the paper argues.–Pharmacological treatments such as the ”love drug” oxytocin could encourage people to act as a group and boost their appreciation of other life forms and nature, [U3] the authors say.–The paper has sparked a storm in the blogosphere. The environmentalist Bill McKibben tweeted that the authors had proposed ”the worst climate-change solutions of all time”. They have also been denounced as Nazis and ecofascists.–The authors are bemused but unrepentant. If people were willing to consider ”really dangerous” geoengineering solutions such as using space mirrors to alter the Earth’s solar reflectivity, human engineering should also be on the table, Dr Liao said.—”At least the human engineering solutions we have described rely on tried and tested technology, whose risks, at least at the individual level, are comparatively low and well known.”[U4] —The authors emphasise they are not advocating human engineering be adopted, only that it be considered. They also envisage it as a voluntary activity possibly supported by incentives such as tax breaks or sponsored healthcare, not something coerced or mandatory.—[U5] Dr Sandberg, of the Future of Humanity Institute at Oxford University, said the paper had inadvertently ”managed to press two hot buttons” – climate change and ”messing with human nature”. He predicted the paper would mutate into a story that scientists were working on re-engineering people to be green and it would be adopted as ”yet another piece of evidence of the Big Conspiracy”.—This story was found at: http://www.smh.com.au/world/science/final-frontier-of-climate-policy–remake-humans-20120405-1wfo6.html

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Reverse Engineering Epilepsy’s ‘Miracle’ Diet

ScienceDaily (May 23, 2012) — For decades, neurologists have known that a diet high in fat and extremely low in carbohydrates can reduce epileptic seizures that resist drug therapy. But until now, how the diet worked, and why, was a mystery.—Now, researchers at Dana-Farber Cancer Institute and Harvard Medical School have proposed an answer, linking resistance to seizures to a protein that modifies cellular metabolism in the brain. The research, to be published in the May 24th issue of the journal Neuron, may lead to the development of new treatments for epilepsy.–The research was led jointly by Nika Danial, HMS assistant professor of cell biology at Dana-Farber Cancer Institute, and Gary Yellen,professor of neurobiology at Harvard Medical School. The first author was Alfredo Giménez-Cassina, a research fellow in Danial’s lab.—Epilepsy is a neurological disorder characterized by repeated seizures, an electrical storm in the brain that can manifest as convulsions, loss of motor control, or loss of consciousness. Some cases of epilepsy can be improved by a diet that drastically reduces sugar intake, triggering neurons to switch from their customary fuel of glucose to fat byproducts called ketone bodies. The so-called ketogenic diet, which mimics effects of starvation, was described more than 80 years ago and received renewed interest in the 1990s. Recent studies corroborate that it works, but shed little light on how.–“The connection between metabolism and epilepsy has been such a puzzle,” said Yellen, who was introduced to the ketogenic diet through his wife, Elizabeth Thiele, HMS professor of neurology, who directs the Pediatric Epilepsy Program at MassGeneral Hospital for Children, but was not directly involved in the study. “I’ve met a lot of kids whose lives are completely changed by this diet,” Yellen said. “It’s amazingly effective, and it works for many kids for whom drugs don’t work.“—“We knew we needed to come at this link between metabolism and epilepsy from a new angle,” said Danial, who had previously discovered a surprising double duty for a protein known for its role in apoptosis: The protein, BCL-2-associated Agonist of Cell Death, or BAD, also regulated glucose metabolism.–Giménez-Cassina further discovered that certain modifications in BAD switched metabolism in brain cells from glucose to ketone bodies. “It was then that we realized we had come upon a metabolic switch to do what the ketogenic diet does to the brain without any actual dietary therapy,” said Gimenez-Cassina, who went on to show that these same BAD modifications protect against seizures in experimental models of epilepsy. Still, it wasn’t clear exactly how.—Yellen suspected the solution involved potassium ion channels. While sodium and calcium ion channels tend to excite cells, including neurons, potassium channels tend to suppress cell electrical activity. His lab had previously linked ketone bodies to the activation of ATP-sensitive potassium (KATP) channels in neurons. Yellen had hypothesized that the ketogenic diet workedbecause ketone bodies provide neurons enough fuel for normal function, but when the electrical and energy storm of an epileptic seizure threatens, the activated KATP channels can shut the storm down. But the effects of diets are broad and complex, so it was impossible to say for sure—The effects that Danial’s lab had discovered — BAD’s ability to alter metabolism and seizures — offered a new avenue for studying the therapeutic effects of altered metabolism. Together, the researchers decided to investigate whether Danial’s switch governed Yellen’s pathway, and whether they could reverse engineer the seizure protection of a ketogenic diet.–They could. Working in genetically altered mice, the researchers modified the BAD protein to reduce glucose metabolism and increase ketone body metabolism in the brain. Seizures decreased, but the benefit was erased when they knocked out the KATP channel — strong evidence that a BAD-KATP pathway conferred resistance to epileptic seizures. Further experiments suggested that it was indeed BAD’s role in metabolism, not cell death that mattered. The findings make the BAD protein a promising target for new  epilepsy drugs.—“Diet sounds like this wholesome way to treat seizures, but it’s very hard. I mean, diets in general are hard, and this diet is really hard,” said Yellen, whose wife’s Center for Dietary Therapy in Epilepsy hosts a candy-free Halloween party for its many patients on the ketogenic diet. “So finding a pharmacological substitute for this would make lots of people really happy.”—Story Source-The above story is reprinted from materials provided by Harvard Medical School. The original article was written by R. Alan Leo. —Journal Reference–Alfredo Giménez-Cassina, Juan Ramón Martínez-François, Jill K. Fisher, Benjamin Szlyk, Klaudia Polak, Jessica Wiwczar, Geoffrey R. Tanner, Andrew Lutas, Gary Yellen, Nika N. Danial. BAD-Dependent Regulation of Fuel Metabolism and KATP Channel Activity Confers Resistance to Epileptic Seizures. Neuron, 2012; 74 (4): 719 DOI: 10.1016/j.neuron.2012.03.032

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Glucose Deprivation Activates Feedback Loop That Kills Cancer Cells

In cancer cells, glucose starvation activates a metabolic and signaling feedback loop leading to cell death. Glucose starvation induces generation of reactive oxygen species generation (ROS), thereby inhibiting phosphatases and activating tyrosine kinases, which in turn generate additional ROS. This glucose starvation-induced positive feedback loop amplifies ROS levels until cells undergo ROS-mediated cell death. —ScienceDaily (June 26, 2012) — Compared to normal cells, cancer cells have a prodigious appetite for glucose, the result of a shift in cell metabolism known as aerobic glycolysis or the “Warburg effect.” Researchers focusing on this effect as a possible target for cancer therapies have examined how biochemical signals present in cancer cells regulate the altered metabolic state.—Now, in a unique study, a UCLA research team led by Thomas Graeber, a professor of molecular and medical pharmacology, has investigated the reverse aspect: how the metabolism of glucose affects the biochemical signals present in cancer cells.—In research published June 26 in the journal Molecular Systems Biology, Graeber and his colleagues demonstrate that glucose starvation — that is, depriving cancer cells of glucose activates a metabolic and signaling amplification loop that leads to cancer cell death as a result of the toxic accumulation of reactive oxygen species, the cell-damaging molecules and ions targeted by antioxidants like vitamin C.—The research, which involved UCLA scientists from the Crump Institute for Molecular Imaging, the Institute for Molecular Medicine, the California NanoSystems Institute, the Jonsson Comprehensive Cancer Center, the Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research, and the Department of Pathology and Laboratory Medicine, demonstrates the power of systems biology in uncovering relationships between metabolism and signaling at the network level.—“Most strikingly, our discovery that glucose withdrawal causes both cell death and increased tyrosine phosphorylation is intriguing because increased tyrosine kinase signaling is normally associated with cell growth,” said Nicholas A. Graham, a senior postdoctoral scholar in Graeber’s lab who helped design the project.—To explain the seemingly contradictory result that glucose deprivation reduced viability and at the same time increased signaling, the authors used an unbiased systems-biology approach that included phospho-tyrosine mass spectrometry and other biochemical profiling techniques.—Assessing the “crosstalk” between metabolism and signaling, they discovered that the glucose deprivation activates a positive feedback loop whereby the withdrawal of glucose induces increased levels of reactive oxygen species, which in turn inhibit negative regulators of tyrosine signaling. The resulting supra-physiological levels of tyrosine phosphorylation then generate additional reactive oxygen species.—“Because cancer cells live on the edge of what is metabolically feasible, this amplifying cycle of oxidative stress ultimately overwhelms and kills the cancer cell,” Graeber explained. “These findings illustrate the delicate balance that exists between metabolism and signaling in the maintenance of cancer cell homeostasis.”—In addition, the authors showed the possibility of exploiting this positive feedback loop for therapeutic intervention. Combining short-term glucose deprivation with an inhibitor of tyrosine phosphatases, they demonstrated synergistic cell death in a cancer cell line.—“Understanding the links between metabolism and signaling will empower new therapeutic approaches toward inducing this metabolic catastrophe,” Graham said. “This study provides a framework for rational design of combinatorial therapeutics targeting both metabolism and signaling in cancer.”—The findings by Graeber and his colleagues add to the emerging concept of systems integration between oncogenic signaling networks and the metabolism of malignant tumors. The work lays a foundation for future studies delineating how signaling and metabolism are linked, with the ultimate goal of refining therapeutic strategies targeting cancer metabolism.—The research team also included collaborators from the department of neurology and the human oncology and pathogenesis program at Memorial Sloan-Kettering Cancer Center and the department of pharmacology at Weill-Cornell Medical College.—The research was funded by the National Institutes of Health, UCLA’s Jonsson Comprehensive Cancer Center, and the California Institute of Technology-University of California, Los Angeles, Joint Center for Translational Medicine.—Story Source-The above story is reprinted from materials provided by University of California – Los Angeles. The original article was written by Jennifer Marcus. —Journal Reference-Nicholas A Graham, Martik Tahmasian, Bitika Kohli, Evangelia Komisopoulou, Maggie Zhu, Igor Vivanco, Michael A Teitell, Hong Wu, Antoni Ribas, Roger S Lo, Ingo K Mellinghoff, Paul S Mischel, Thomas G Graeber. Glucose deprivation activates a metabolic and signaling amplification loop leading to cell death. Molecular Systems Biology, 2012; 8 DOI: 10.1038/msb.2012.20

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Drinking Coffee with Caffeine may Reduce the risk of Basal Cell Carcinoma

Drinking coffee with caffeine may reduce the risk of basal cell carcinoma, the most common form of skin cancer, a new study suggests. —-“Our data indicate that the more caffeinated coffee you consume, the lower your risk of developing basal cell carcinoma,” said Jiali Han, associate professor at Brigham and Women’s Hospital, Harvard Medical School in Boston and Harvard School of Public Health. The findings add to other apparent benefits of coffee, which has been at least suggestively linked to lower risk of depression in women and may counteract cognitive decline. Coffee may even help prevent Alzheimer’s, Parkinson’s disease and type 2 diabetes. [Coffee Habits: Infographic] — “Our results add basal cell carcinoma to a list of conditions for which risk is decreased with increasing coffee consumption,” Han in a statement. “This list includes conditions with serious negative health consequences such as type 2 diabetes and Parkinson’s disease.”— Han and his colleagues studied data from the Nurses’ Health Study, a large and long-running study to aid in the investigation of factors influencing women’s health, and the Health Professionals Follow-up Study, a similar study for men.—Of the 112,897 participants included in the analyses, 22,786 developed basal cell carcinoma during the more than 20 years of follow-up in the two studies, the researchers explained in a statement. Lower risk of developing basal cell carcinoma was linked to consumption of caffeinated coffee as well as caffeine from other sources: tea, cola and chocolate. Decaffeinated coffee did not have the same effect.—These results really suggest that it is the caffeine in coffee that is responsible for the decreased risk of basal cell carcinoma associated with increasing coffee consumption,” Han said. “This would be consistent with published mouse data, which indicate caffeine can block skin tumor formation. However, more studies in different population cohorts and additional mechanistic studies will be needed before we can say this definitively.”—No link was established between caffeine consumption and risk for two other forms of skin cancer, squamous cell carcinoma and melanoma, the most deadly form of the disease.—The findings are detailed in Cancer Research, a journal of the American Association for Cancer Research.

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Moderate Coffee Consumption Offers Protection Against Heart Failure

New research shows a possible benefit from coffee consumption, but like with so many other things we consume, it really depends on how much coffee you drink, the researchers say. —ScienceDaily (June 26, 2012) — While current American Heart Association heart failure prevention guidelines warn against habitual coffee consumption, some studies propose a protective benefit, and still others find no association at all. Amidst this conflicting information, research from Beth Israel Deaconess Medical Center attempts to shift the conversation from a definitive yes or no, to a question of how much.—“Our results did show a possible benefit, but like with so many other things we consume, it really depends on how much coffee you drink,” says lead author Elizabeth Mostofsky, MPH, ScD, a post-doctoral fellow in the cardiovascular epidemiological unit at BIDMC. “And compared with no consumption, the strongest protection we observed was at about four European, or two eight-ounce American, servings of coffee per day.”—The study published June 26 online in the journal Circulation: Heart Failure, found that these moderate coffee drinkers were at 11 percent lower risk of heart failure.—Data was analyzed from five previous studies — four conducted in Sweden, one in Finland — that examined the association between coffee consumption and heart failure. The self-reported data came from 140,220 participants and involved 6,522 heart failure events.—In a summary of the published literature, the authors found a “statistically significant J-shaped relationship” between habitual coffee consumption and heart failure, where protective benefits begin to increase with consumption maxing out at two eight-ounce American servings a day. Protection slowly decreases the more coffee is consumed until at five cups, there is no benefit and at more than five cups a day, there may be potential for harm.—It’s unclear why moderate coffee consumption provides protection from heart failure, but the researchers say part of the answer may lie in the intersection between regular coffee drinking and two of the strongest risk factors for heart failure — diabetes and elevated blood pressure.–“There is a good deal of research showing that drinking coffee lowers the risk for type 2 diabetes, says senior author Murray Mittleman, MD, DrPH, a physician in the Cardiovascular Institute at Beth Israel Deaconess Medical Center, an Associate Professor of Medicine at Harvard Medical School and director of BIDMC’s cardiovascular epidemiological research program. “It stands to reason that if you lower the risk of diabetes, you also lower the risk of heart failure.”—There may also be a blood pressure benefit. Studies have consistently shown that light coffee and caffeine consumption are known to raise blood pressure. “But at that moderate range of consumption, people tend to develop a tolerance where drinking coffee does not pose a risk and may even be protective against elevated blood pressure,” says Mittleman.–This study was not able to assess the strength of the coffee, nor did it look at caffeinated versus non-caffeinated coffee.—“There is clearly more research to be done,” says Mostofsky. “But in the short run, this data may warrant a change to the guidelines to reflect that coffee consumption, in moderation, may provide some protection from heart failure.”–Other study authors are Megan Rice, Sc.D., and Emily Levitan, Sc.D.-The research was supported by grants from the National Institutes of Health.–Story Source-The above story is reprinted from materials provided by Beth Israel Deaconess Medical Center, via Newswise

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Tony Pantellaresco Show Notes For The Week June 18 2012

Today’s Environment Influences Behavior Generations Later:

Chemical Exposure Raises Descendants’ Sensitivity to Stress

 

Genetic Mutation in African Malaria Parasite Shown to Give Resistance to Best Drugs

 

Chernobyl Deaths Top a Million Based on Real Evidence

 

Estriol- Benefits

New protein study could shake up sports nutrition market-Or Kill It!

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Today’s Environment Influences Behavior Generations Later:

 

Chemical Exposure Raises Descendants’ Sensitivity to Stress

Researchers have seen an increased reaction to stress in animals whose ancestors were exposed to an environmental compound generations earlier. —ScienceDaily (May 21, 2012) — Researchers at The University of Texas at Austin and Washington State University have seen an increased reaction to stress in animals whose ancestors were exposed to an environmental compound generations earlier.—The findings, published in the latest Proceedings of the National Academy of Sciences, put a new twist on the notions of nature and nurture, with broad implications for how certain behavioral tendencies might be inherited.[U1] –The researchers — David Crews at Texas , Michael Skinner at Washington State and colleagues — exposed gestating female rats to vinclozolin, a popular fruit and vegetable fungicide known to disrupt hormones and have effects across generations of animals.[U2] The researchers then put the rats’ third generation of offspring through a variety of behavioral tests and found they were more anxious, more sensitive to stress, and had greater activity in stress-related regions of the brain than descendants of unexposed rats.—We are now in the third human generation since the start of the chemical revolution, since humans have been exposed to these kinds of toxins,” says Crews. “This is the animal model of that.”—“The ancestral exposure of your great grandmother alters your brain development to then respond to stress differently,” says Skinner. “We did not know a stress response could be programmed by your ancestors’ environmental exposures.”[U3] The researchers had already shown exposure to vinclozolin can effect subsequent generations by affecting how genes are turned on and off, a process called epigenetics. In that case, the epigenetic transgenerational inheritance altered how rats choose mates.[U4] The new research deepens their study of the epigenetics of the brain and behavior, dealing for the first time with real-life challenges like stress. It also takes a rare systems biology approach, looking at the brain from the molecular level to the physiological level to behavior.—“We did not know a stress response could be reprogrammed by your ancestors’ environmental exposures,” says Skinner, who focused on the epigenetic transgenerational inheritance and genomics aspects of the paper. “So how well you socialize or how your anxiety levels respond to stress may be as much your ancestral epigenetic inheritance as your individual early-life events.” This could explain why some individuals have issues with post-traumatic stress syndrome while others do not, he says. Crews says that increases in other mental disorders may be attributable to the kind of “two-hit” exposure that the experiment is modeling.[U5] “There is no doubt that we have been seeing real increases in mental disorders like autism and bipolar disorder,” says Crews, who focused on the neuroscience, behavior and stress aspects of the paper. “It’s more than just a change in diagnostics. The question is why? Is it because we are living in a more frantic world, or because we are living in a more frantic world and are responding to that in a different way because we have been exposed? I favor the latter.” The researchers also saw intriguing differences in weight gain, opening the door to further research on obesity. Story Source-The above story is reprinted from materials provided by Washington State University. The original article was written by Eric Sorensen. –Journal Reference-David Crews, Ross Gillette, Samuel V. Scarpino, Mohan Manikkam, Marina I. Savenkova, and Michael K. Skinner. Epigenetic transgenerational inheritance of altered stress responses. Proceedings of the National Academy of Sciences, May 21, 2012 DOI: 10.1073/pnas.1118514109

 

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Genetic Mutation in African Malaria Parasite Shown to Give Resistance to Best Drugs

 

ScienceDaily (Apr. 27, 2012) — Scientists have identified genetic mutations[U6] in the deadliest malaria parasite in Africa that are giving it resistance to one of the most powerful anti-malarial drugs. The researchers say their findings are a further warning that the best weapons against malaria could become obsolete.–The artemisinin group of drugs are the most effective and widely used treatments for malaria. They are most powerful and less likely to be resisted by the malaria parasite when used with other drugs as artemisinin-based combination therapies (ACTs). But the new study confirms previous suggestions that mutations in a key part of the parasite can provide resistance to artemether, one of the two most effective artemisinins.—The research group, led by a team at St George’s, University of London, discovered artemether resistance in parasite samples taken from 11 of the 28 malaria-infected patients in the study. On average, artemether’s effectiveness was reduced by half. Each parasite was found to have the same genetic mutations.[U7] —The patients were infected by malaria parasite-carrying mosquitoes while travelling abroad, mostly in sub-Saharan Africa, home to 90 per cent of the one million people killed worldwide each year by malaria.—Study lead Professor Sanjeev Krishna said: “Artemether and ACTs are still very effective, but this study confirms our fears of how the parasite is mutating to develop resistance. Drug resistance could eventually become a devastating problem in Africa, and not just in south east Asia where most of the world is watching for resistance. Effective alternative treatments are currently unaffordable for most suffering from malaria[U8] . Finding new drugs is, therefore, crucial.” In the study, published online April 27, 2012 in BioMed Central’s open access journal Malaria Journal, the researchers tested samples from patients infected with the Plasmodium falciparum parasite. This parasite causes the deadliest form of malaria, and is responsible for nine out of 10 malaria deaths. [U9] The parasites were assessed for their sensitivity to four artemisinins — artemisinin itself, artemether, dihydroartemisinin and artesunate.—The 11 parasites showing artemether resistance had the same genetic mutations in an internal system called the calcium pump. This is used to transport calcium, crucial for the parasite to function. The researchers already suspected that the calcium pump — which they first showed was a target for artemisinins to work on in 2003 — had the potential to develop artemisinin resistance. But this had been difficult to confirm until now.—Artemether resistance was strongest in several cases where a separate mutation in another transport system — a protein called pfmdr1, already associated with drug resistance — also occurred.—The effectiveness of the other artemisinins was not significantly affected by the mutations. This may be because they were able to work on other transport systems in the parasite, compensating for the effects of resistance mutations in the calcium pump.—However, Professor Krishna added: “At the moment, we do not know if the other artemisinins will follow suit, but given the shared chemistry they have with artemether it is tempting to think that they would.”—He added that resistance could be a result of the increasing use of ACTs, 300 million doses of which were dispensed worldwide in 2011. Greater use could offer the parasites more opportunities to develop genetic mutations that provide resistance. This could, the researchers say, lead to a repeat of how the parasite developed resistance to pre-artemisinin drugs such as chloroquine. Incorrect use of anti-malarials, such as not completing the treatment course or taking sub-standard drugs, could aid this process.—Professor Krishna said: “New drug development is paramount, but it is vital that we also learn more about how artemisinins work so we can tailor ACT treatments to be effective for as long as possible.”—-Story Source-The above story is reprinted from materials provided by University of St George’s London, via AlphaGalileo. —Journal Reference-Dylan R Pillai, Rachel Lau, Krishna Khairnar, Rosalba Lepore, Allegra Via, Henry M Staines, Sanjeev Krishna. Artemether resistance in vitro is linked to mutations in PfATP6 that also interact with mutations in PfMDR1 in travellers returning with Plasmodium falciparum infections. Malaria Journal, 2012; 11 (1): 131 DOI: 10.1186/1475-2875-11-131

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Chernobyl Deaths Top a Million Based on Real Evidence
Medical records from contaminated areas speak for themselves; doctors, scientists and citizens bear witness to the devastating health impacts of radioactive fallout from nuclear accidents Dr. Mae-Wan Ho
Official denial by nuclear lobby—The Chernobyl disaster occurred on 26 April 1986 at the Chernobyl Nuclear Power -Plant near the city of Prypiat in Ukraine, then part of the Soviet Union, and close to the administrative border with Belarus.  A sudden power output surge prompted an attempt at emergency shutdown; but a more extreme spike in power output led to the rupture of a reactor vessel and a series of explosions. The graphite moderator was exposed, causing it to ignite, and the resulting fire sent a plume of highly radioactive fallout over large parts of the western Soviet Union and Europe. From 1986 to 2000, 350 400 people were evacuated
and resettled from the most contaminated areas of Belarus, Russia and Ukraine. According to official post-Soviet data, about 57 % of the fallout landed in Belarus [1]. Chernobyl is widely considered to have been the worst nuclear accident in history and one of only two classified as a level 7 event on the International Nuclear Event Scale, the other being the Fukushima Daiichi nuclear meltdown in 2011 (see [2] Fukushima Nuclear Crisis, SiS 50).— From the beginning, the official nuclear safety experts were at pains to minimise the projected health impacts, as they are doing now for the Fukushima accident.  The UNSCEAR (United Nations Scientific Committee on the Effects of Atomic Radiation) estimated a “global collective dose” of radiation exposure from the accident “equivalent on average to 21 additional days of world exposure to natural background radiation”. Successive studies reported by the IAEA (International Atomic Energy Agency) continued to underestimate the level of exposure and to understate health impacts other than [3] “psychosocial effects, believed to be unrelated to radiation exposure” resulting from the lack of information immediately after the accident, “the stress and trauma of compulsory relocation to less contaminated areas, the breaking of social ties and the fear that radiation exposure could cause  health damage in the future.”——The number of deaths attributed to Chernobyl varies widely [1]. Thirty-one deaths are directly attributed to the accident, all among the reactor staff and emergency workers. An UNSCEAR report places the total confirmed deaths from radiation at 64 as of 2008. The Chernobyl Forum [4] founded in February 2003 at the IAEA Headquarters in Vienna with representatives from IAEA and UN agencies including UNSCEAR, WHO,  the World Bank, and Belarus, Russia and Ukraine, estimates that the eventual death toll could reach 4 000 among those exposed to the highest levels of radiation (200 000 emergency workers, 115 000 evacuees and 270 000 residents of the most contaminated areas); the figure includes some 50 emergency workers who died of acute radiation syndrome, 9 children who died of thyroid cancer and an estimated total of 3950 deaths from radiation-induced cancer and leukemia. The Union of Concerned Scientists based in Washington in the United States estimates another 50 000 excess cancer cases among people living in areas outside the most contaminated, and 25 000 excess deaths. A Greenpeace report puts the figure at 200 000 or more. The Russian publication, Chernobyl, by scientists Alexey V. Yablokov, Vassily B Nesterenko, and Alexey V. Nesterenko, translated and published by the New York Academy of Sciences in 2009, concludes that among the billions of people worldwide who were exposed to radioactive contamination from the disaster, nearly a million deaths had already occurred between 1986 and 2004. Most of the deaths were in Russia, Belarus and Ukraine [5] (see Truth about Chernobyl, SiS 47). The report drew on thousands of published papers and internet and printed publications. Those publications and papers, written by leading Eastern authorities, were downplayed or ignored by the IAEA and UNSCEAR. These agencies minimised their estimates by several ploys including [6]—– Underestimating the level of radiation by averaging exposure over a large regions, such as an entire country; so high exposure doses and health statistics of the most contaminated areas are lumped together with the less and least exposed

– Ignoring internal sources of radiation due to inhalation and ingestion of radioactive material from fallout
– Using an obsolete and erroneous model of linear energy transfer due to external sources of ionising radiation
– Not counting diseases and conditions other than cancers
– Overestimating the natural background radiation; today’s ‘background’ has been greatly increased by discharges from nuclear activities including tests of nuclear weapons, use of depleted uranium, and uranium mining
– Suppressing and withholding information from the public.
Nevertheless, the devastating health impacts did not escape the notice of the hundreds of doctors, scientists and other citizens who had to bear witness to the deformities, sicknesses and deaths of exposed babies, children and adults in their care. -Diversity of health impacts and their global extent over generations to come Alexei Yablokov, distinguished academician of the Russian Academy of Sciences in Moscow, spoke at the Scientific and Citizen Forum on adioprotection – From Chernobyl to Fukushima, 11-13 May 2012 in Geneva [7]. He is adamant that the consequences of the Chernobyl disaster can be clearly demonstrated by comparing the states of people’s health in areas receiving different amounts of additional radiation following the accident, instead of one based on average effective dose calculated by the ICRP and UNSCEAR which underestimates the true levels of irradiation. For example, there is a clear difference in mortality rates between highly contaminated provinces and less contaminated provinces of Russia (see Figure 1).  Yablokov is lead author of a massive report, now in its third enlarged 2011 edition [8], which has collated all the available evidence.

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Estriol- Benefits

Estriol, an estrogen that has virtually been ignored by the mainstream medical community, is one of the three principal estrogens produced by the body. Estriol was originally thought to have little significance due to its weak estrogenic activity when compared with estrone and estradiol. Nonetheless, research has found that its weakness may very well be its strength. –Studies suggest that when the lower-potency estrogen, estriol, is administered topically, it does not increase the risk of hormone-dependent cancers of the breast or endometrium (uterine lining).1-3 However, having weaker estrogenic effects does not mean that estriol has none of the benefits that come with more potent estrogens. Studies suggest that estriol reduces symptoms of menopause, such as hot flashes and vaginal dryness, but with a better safety profile compared with more potent estrogens.1,4,5 This makes estriol a better choice for bioidentical hormone-replacement treatment regimes. –That is not all this ‘weak’ hormone is good for! Research suggests that estriol has benefits for bone density, heart health, multiple sclerosis, and postmenopausal urinary tract health.6-12 In this article, we will review the attributes of this ‘weaker’ estrogen, and why this estrogen is currently in the news.

F     The body naturally makes three estrogen hormones—estradiol, estrone, and estriol. Since estriol possesses the weakest estrogenic effects of the three, it has been largely overlooked by the medical community.

  • Many studies show that estriol offers a wealth of potential health benefits—without the dangers that sometimes accompany higher-potency estrogens and synthetic or horse-derived hormones.
  • Studies suggest that estriol helps relieve menopausal symptoms while benefitting bone and urinary tract health. Estriol may also help improve cardiovascular risk factors and even shows promise in reducing the brain lesions of multiple sclerosis.
  • The most reliable way to measure estriol levels is through 24-hour urine collection.
  • Despite abundant evidence to the contrary, the FDA has recently claimed that estriol is not safe. You can act now to help preserve consumers’ access to bioidentical hormones such as estriol by visiting http://www.homecoalition.org.

Fear of cancer prevents many women from restoring youthful hormone levels. When applied through the topical (transdermal) route, estriol is not associated with increased cancer risk. Other methods women can use to prevent hormone-related cancers include consuming regular amounts of vitamin D,  and Bioflavonoids, Tumeric,Rosemary,Parsley,Dandelion, Hawthorn Berry, Black tea and Black Tea extracts, Celery Root, regulating meat and high-fat dairy intake.—

Estriol and Hormone Replacement Therapy

In addition, several studies suggest that bioidentical estrogen has less health risk when given with low doses of bioidentical progesterone.26,27— if you are on hormone-replacement therapy (HRT) and have never heard of estriol, you might be wondering why not? Before the 1970s, estriol was thought to have significance only during pregnancy we saw the beginning of hormone-replacement therapy with patented equine estrogens such as Premarin® and synthetic progestins as found in Provera®. By the 1990s, one-third of menopausal women were taking Premarin®. Research uncovered the increased incidence of breast cancer, increased risk of blood clotting, and increased cardiovascular risk associated with the use of these horse-derived and synthetic hormones (used in combination in the patented medication Prempro®).13 The medical community began to wonder if using hormones from pregnant horses was such a good idea. In an effort to find a safer alternative, many patients and practitioners began looking into ‘natural’ hormone-replacement treatment using bioidentical hormones, which are identical to those produced naturally within the body. Bioidentical-hormone replacement was pioneered in the 1980s as a treatment for menopause by Dr. Jonathan Wright in Washington state. ——-Interest in estriol increased as it was discovered that estriol was safer than horse-derived and synthetic hormones in relation to cardiovascular health and potentially cancer risk. Unfortunately, many doctors have not adopted its use, and many bioidentical hormone-replacement regimes use only estradiol, a more potent estrogen
with increased associated risks.-
— The benefits of estriol may, in part, be explained by the mixed pro-estrogenic and anti-estrogenic effects of this interesting estrogen hormone. Scientists Melamed et al. investigated the mixture of stimulating and non-stimulating effects posed by estriol upon estrogen receptors. When estriol is given together with estradiol, the estradiol-specific stimulation to cells is decreased. This little-appreciated scientific fact helps to explain how estriol can reduce pro-carcinogenic effects of more powerful estrogens like estradiol. However, when estriol is given alone over a long period of time, it can produce a more complete pro-estrogenic effect, explaining why symptom relief is achieved when menopausal women take estriol.2 Experimental studies suggest that both estriol and tamoxifen (a synthetic anti-estrogen) have protective effects against radiation-induced cancer of the breast[U10] .14— Most of the research cited in this article used oral estrogen as the route of administration. However, for enhanced safety, topical estriol would be a better choice. Several studies have shown that transdermal estrogen confers less health risk as a route of administration than oral estrogen.3,21-25 Clinical experience of many doctors over the past 20-30 years suggests that transdermal estrogen is also more effective for some women. This is largely thought to be due to the ‘first-pass effect’—meaning that orally ingested drugs are often first metabolized in the liver, before having any activity in the body. Orally ingested estrogen hormones are among these drugs that are first metabolized in the liver before exerting their effects in the body. Physicians experienced in hormone replacement often observe that women treated with oral estrogens show high levels of estrogen metabolites in 24-hour urine specimens, suggesting that most of the orally ingested hormones are being excreted.———- In a prospective study funded by the US Army and performed at the Public Health Institute, Berkeley, California, researchers compared estriol levels during pregnancy with breast cancer incidence 40 years later. Results revealed that of the 15,000 women entered in the study, those with the highest levels of estriol relative to other estrogens during pregnancy had the lowest cancer risk. In other words, as the relative level of estriol increased during pregnancy, risk of breast cancer decreased 40 years later. In fact, women with the highest level of estriol during pregnancy had 58% lower risk for breast cancer compared with women who had the lowest serum estriol levels. The authors also noted that Asian and Hispanic women had higher estriol levels compared with other racial groups. Interestingly, Asian and Hispanic women have the lowest breast cancer rates. The authors concluded, “If confirmed, these results could lead to breast cancer prevention or treatment regimens that seek to block estradiol estrogen action using estriol, similar to treatment based on the synthetic anti-estrogen tamoxifen.”15 —In another study, Takahashi et al. studied the safety of estriol treatment for Menopausal symptoms. Fifty-three women with either surgically induced or natural menopause were given 2 mg of oral estriol/day for 12 months. Endometrial and breast assessments done with endometrial biopsy and breast ultrasound, respectively, found normal results in all women. The authors concluded that over a 12-month period, “estriol appeared to be safe and effective in relieving symptoms of menopausal women.”1—In one investigation, 52 postmenopausal women were given 2 mg, 4 mg, 6 mg, or 8 mg/day of oral estriol for six months. In all patients, vasomotor symptoms of menopause (such as hot flashes) were decreased. The most improvement was experienced by women taking the highest dose of 8 mg. There were no signs of endometrial hyperplasia confirmed by endometrial biopsy over the six-month treatment period. Mammograms were obtained on six of the patients who had mammary hyperplasia at the study’s outset, and no further changes were seen.8- Although the oral route of administration of estriol appears relatively safe over the short-term, the transdermal route is preferred for long-term use. For example, Weiderpass et al. found an increased risk of endometrial atypical hyperplasia and endometrial cancer with oral use of estriol, but not with transdermal estriol over at least a five-year period. Compared with no use of estriol, those who took oral estriol for at least five years had a significantly greater risk, compared with individuals who did not take any estriol. Women using topical estriol for at least five years did not have any increased risk.

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New protein study could shake up sports nutrition market-Or Kill It!

A study out this week could add a new player to the protein market that’s long been dominated by whey.–At the Experimental Biology meeting in San Diego on Monday, Blake Rasmussen, PhD, of the University of Texas Medical Branch, presented findings that show a blend of protein sources—50 percent casein, 25 percent whey, 25 percent soy—was superior to whey alone for prolonging muscle building and recovery after exercise.[U11] “Whey protein has been given considerable notice as the gold standard ingredient after exercise to enhance muscle growth,” Rasmussen said. “The main problem with whey is it’s fast digesting—the anabolic response in muscle is only about an hour. We wanted to prolong the anabolic response with other protein sources. We found muscle protein synthesis is elevated for a longer amount of time with a protein blend versus whey protein.”[U12] The combination of protein blends was determined in Rasmussen’s previous preclinical work with rats.–Soy, whey and casein protein are all absorbed at different rates during digestion[U13] . Whey protein is referred to as a “fast” protein because it is rapidly absorbed, between 30 and 60 minutes, Rasmussen said. Soy is an intermediate protein, taking between 60 and 120 minutes to digest. And casein is a slow protein, requiring between three and five hours to digest.-“The combination gives you a quick increase in protein synthesis, and it gets sustained,” said Rasmussen. “It’s a prolonged delivery to muscle that the muscles use for recovery.”-The double-blind, randomized clinical trial followed 19 young adults before and after ingestion of about 19 grams of protein from the blend or about 17.5 grams of whey protein alone.

“Your muscles don’t recover in 30 minutes. It takes at least 24 to 48 hours for your muscles to recover after a resistance exercise,” said Greg Paul, global marketing director for sports nutrition and weight management at Solae, a soy supplier that sponsored the study.[U14]

Not just for athletes anymore?—It was only five years ago when research showed that protein should be an important part of sports nutrition products. Before then, the game was typically provided by the likes of Gatorade-style drinks: with fast carbs and electrolytes such as potassium and sodium.–Whey became the go-to protein source in beverages because it quickly fed muscles. Whey also appears better than soy for producing muscle synthesis because of the presence in whey of the amino acid leucine, which has been shown to uniquely act as a stimulatory signal for muscle protein synthesis. But for athletes and weekend warriors alike, using a blend of protein sources that absorb in the body over time means muscles are being fed until the next meal.

The addition of soy is also important because of soy’s particular properties including as an antioxidant and as an anti-inflammatory, which are both key attributes in muscle building beyond anabolic[U15] effects.

And this could lead to the next great demographic for protein products: the elderly.–“Protein blends are useful for sports nutrition,” said Rasmussen, “but also for those interested in aging and maintaining muscle mass as we age. This could potentially be a great intervention for aging.”[U16] -To date, products targeting elderly nutrition with protein-centric value propositions are few and far between. The trend of aging baby boomers, coupled with research demonstrating the value of protein blends in maintaining muscle mass, ought to be of interest to marketers and product developers. [U17]

 

TOP D


[U1]Again Not Genetic as they perpetrate—but a preconditioning to create the anomaly intended—an experiment of control and dependency and debilitation

[U2]Disruptor of the endocrine system—then what happens when you add several different disruptors of the endocrine system? Sterilization!!

[U3]Imagine the duress our lineage will have as a result of the –soy poisoning—chemtrail poisoning-vaccination poisoning –genetically modified food poisoning-environmental—they will be beyond xenophobic and will be told they have a genetic disposition to XYZ infections or conditions or potential invasion from a pathogen specific to there DNA structure—all lies—a direct result of intervention of a evil kind causing this to occur in 3 generations

[U4]It would appear they would possibly chose as a direct result of those who also would have hade these inherited genes –further compounding the problem and  causing  more issues

[U5]A Binary attack to hit and violate at the same time causing a breakdown

[U6]How interesting —we have a GMM= genetically  modified malaria—doe that not make you go hmmmmm wonder how it got genetically enhanced to resist what once cured it !!?—Is it not interesting that we have a new species of Malaria now—apparently the old one was not killing people off fast enough so now the pharma’ have decided to make this  a better pathogen

[U7]WARNING WARNING—Understand this—Genetic Mutation–

[U8]Interesting—if they had the  money they could be relieved but no money and they are held hostage by the IMF—what a crock

[U9] 90% kill ratio—-am I the only one seeing this is not a natural cause—weoponized malaria??

[U10]Utilizing black tea in a concentrated form  has actually the same effect as tamoxifen without the unwanted side effects

[U11]You never Mix a casein with a Soy they are highly allergenic and will cause all kinds of intestinal break down–The soy itself is an idigestible protein that cause intestinal and pancreatic cancers—avoid this

[U12]This is true—but the issue is how it is blended—the idea that you can mix a good egg or animal protein wih the whey would make this far superior to there method and without the allergens associated  with the Soy

[U13]This is true whey is in and out in about 2 hours casein in and out in about 4-6 hours-Soy can take a month due to the fact it does not digest and in fact causes intestinal disruptions and pancreatic shutdown—so they are right in the blending but wrong in how they blend

[U14]NOW YOU SEE WHO DID THE STUDY- A CONFLICT OF INTREREST SINCE THEY  TRIED TO PATENT SOY-AND THE ISRAELI GOV’T STOPPED THEM FROM ATTAINING THIS AND IN FACT GAVE SOME OF THE HARSHEST CRITIQUE ON SOY AND WHO COULD EAT IT—ESSENTIALLY NO ONE BASED ON THOSE STUDIES

[U15]This is at  best  a fabrication go to the soy links at http://augmentinforce.50webs.com

and read for your self the 4 studies that are there—even the FDA since 1904  knew Soy was toxic and not meant to consume

[U16]If this is followed this will exacerbate an already compromised colon and or pancreas—this advice Should not be followed at all—this was obviously done by someone trying to get ahead at the elderly expense

[U17]This is a form of  euphanasia—food poisoning the elderly

Posted in Health Politics, Remedies, The Remedy Show notes | Leave a comment

Show Of The Week June 18 2012

 

Special Note

“I have sworn upon the altar of God eternal hostility against every form of tyranny over the mind of man!!!!!

– Thomas Jefferson “

 

Today’s Environment Influences Behavior Generations Later:

Chemical Exposure Raises Descendants’ Sensitivity to Stress

 

Genetic Mutation in African Malaria Parasite Shown to Give Resistance to Best Drugs

 

Chernobyl Deaths Top a Million Based on Real Evidence

 

Estriol- Benefits

New protein study could shake up sports nutrition market-Or Kill It!

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Today’s Environment Influences Behavior Generations Later:

 

Chemical Exposure Raises Descendants’ Sensitivity to Stress

Researchers have seen an increased reaction to stress in animals whose ancestors were exposed to an environmental compound generations earlier. —ScienceDaily (May 21, 2012) — Researchers at The University of Texas at Austin and Washington State University have seen an increased reaction to stress in animals whose ancestors were exposed to an environmental compound generations earlier.—The findings, published in the latest Proceedings of the National Academy of Sciences, put a new twist on the notions of nature and nurture, with broad implications for how certain behavioral tendencies might be inherited.[U1] –The researchers — David Crews at Texas , Michael Skinner at Washington State and colleagues — exposed gestating female rats to vinclozolin, a popular fruit and vegetable fungicide known to disrupt hormones and have effects across generations of animals.[U2] The researchers then put the rats’ third generation of offspring through a variety of behavioral tests and found they were more anxious, more sensitive to stress, and had greater activity in stress-related regions of the brain than descendants of unexposed rats.—We are now in the third human generation since the start of the chemical revolution, since humans have been exposed to these kinds of toxins,” says Crews. “This is the animal model of that.”—“The ancestral exposure of your great grandmother alters your brain development to then respond to stress differently,” says Skinner. “We did not know a stress response could be programmed by your ancestors’ environmental exposures.”[U3] The researchers had already shown exposure to vinclozolin can effect subsequent generations by affecting how genes are turned on and off, a process called epigenetics. In that case, the epigenetic transgenerational inheritance altered how rats choose mates.[U4] The new research deepens their study of the epigenetics of the brain and behavior, dealing for the first time with real-life challenges like stress. It also takes a rare systems biology approach, looking at the brain from the molecular level to the physiological level to behavior.—“We did not know a stress response could be reprogrammed by your ancestors’ environmental exposures,” says Skinner, who focused on the epigenetic transgenerational inheritance and genomics aspects of the paper. “So how well you socialize or how your anxiety levels respond to stress may be as much your ancestral epigenetic inheritance as your individual early-life events.” This could explain why some individuals have issues with post-traumatic stress syndrome while others do not, he says. Crews says that increases in other mental disorders may be attributable to the kind of “two-hit” exposure that the experiment is modeling.[U5] “There is no doubt that we have been seeing real increases in mental disorders like autism and bipolar disorder,” says Crews, who focused on the neuroscience, behavior and stress aspects of the paper. “It’s more than just a change in diagnostics. The question is why? Is it because we are living in a more frantic world, or because we are living in a more frantic world and are responding to that in a different way because we have been exposed? I favor the latter.” The researchers also saw intriguing differences in weight gain, opening the door to further research on obesity. Story Source-The above story is reprinted from materials provided by Washington State University. The original article was written by Eric Sorensen. –Journal Reference-David Crews, Ross Gillette, Samuel V. Scarpino, Mohan Manikkam, Marina I. Savenkova, and Michael K. Skinner. Epigenetic transgenerational inheritance of altered stress responses. Proceedings of the National Academy of Sciences, May 21, 2012 DOI: 10.1073/pnas.1118514109

 

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Genetic Mutation in African Malaria Parasite Shown to Give Resistance to Best Drugs

 

ScienceDaily (Apr. 27, 2012) — Scientists have identified genetic mutations[U6] in the deadliest malaria parasite in Africa that are giving it resistance to one of the most powerful anti-malarial drugs. The researchers say their findings are a further warning that the best weapons against malaria could become obsolete.–The artemisinin group of drugs are the most effective and widely used treatments for malaria. They are most powerful and less likely to be resisted by the malaria parasite when used with other drugs as artemisinin-based combination therapies (ACTs). But the new study confirms previous suggestions that mutations in a key part of the parasite can provide resistance to artemether, one of the two most effective artemisinins.—The research group, led by a team at St George’s, University of London, discovered artemether resistance in parasite samples taken from 11 of the 28 malaria-infected patients in the study. On average, artemether’s effectiveness was reduced by half. Each parasite was found to have the same genetic mutations.[U7] —The patients were infected by malaria parasite-carrying mosquitoes while travelling abroad, mostly in sub-Saharan Africa, home to 90 per cent of the one million people killed worldwide each year by malaria.—Study lead Professor Sanjeev Krishna said: “Artemether and ACTs are still very effective, but this study confirms our fears of how the parasite is mutating to develop resistance. Drug resistance could eventually become a devastating problem in Africa, and not just in south east Asia where most of the world is watching for resistance. Effective alternative treatments are currently unaffordable for most suffering from malaria[U8] . Finding new drugs is, therefore, crucial.” In the study, published online April 27, 2012 in BioMed Central’s open access journal Malaria Journal, the researchers tested samples from patients infected with the Plasmodium falciparum parasite. This parasite causes the deadliest form of malaria, and is responsible for nine out of 10 malaria deaths. [U9] The parasites were assessed for their sensitivity to four artemisinins — artemisinin itself, artemether, dihydroartemisinin and artesunate.—The 11 parasites showing artemether resistance had the same genetic mutations in an internal system called the calcium pump. This is used to transport calcium, crucial for the parasite to function. The researchers already suspected that the calcium pump — which they first showed was a target for artemisinins to work on in 2003 — had the potential to develop artemisinin resistance. But this had been difficult to confirm until now.—Artemether resistance was strongest in several cases where a separate mutation in another transport system — a protein called pfmdr1, already associated with drug resistance — also occurred.—The effectiveness of the other artemisinins was not significantly affected by the mutations. This may be because they were able to work on other transport systems in the parasite, compensating for the effects of resistance mutations in the calcium pump.—However, Professor Krishna added: “At the moment, we do not know if the other artemisinins will follow suit, but given the shared chemistry they have with artemether it is tempting to think that they would.”—He added that resistance could be a result of the increasing use of ACTs, 300 million doses of which were dispensed worldwide in 2011. Greater use could offer the parasites more opportunities to develop genetic mutations that provide resistance. This could, the researchers say, lead to a repeat of how the parasite developed resistance to pre-artemisinin drugs such as chloroquine. Incorrect use of anti-malarials, such as not completing the treatment course or taking sub-standard drugs, could aid this process.—Professor Krishna said: “New drug development is paramount, but it is vital that we also learn more about how artemisinins work so we can tailor ACT treatments to be effective for as long as possible.”—-Story Source-The above story is reprinted from materials provided by University of St George’s London, via AlphaGalileo. —Journal Reference-Dylan R Pillai, Rachel Lau, Krishna Khairnar, Rosalba Lepore, Allegra Via, Henry M Staines, Sanjeev Krishna. Artemether resistance in vitro is linked to mutations in PfATP6 that also interact with mutations in PfMDR1 in travellers returning with Plasmodium falciparum infections. Malaria Journal, 2012; 11 (1): 131 DOI: 10.1186/1475-2875-11-131

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Chernobyl Deaths Top a Million Based on Real Evidence
Medical records from contaminated areas speak for themselves; doctors, scientists and citizens bear witness to the devastating health impacts of radioactive fallout from nuclear accidents Dr. Mae-Wan Ho
Official denial by nuclear lobby—The Chernobyl disaster occurred on 26 April 1986 at the Chernobyl Nuclear Power -Plant near the city of Prypiat in Ukraine, then part of the Soviet Union, and close to the administrative border with Belarus.  A sudden power output surge prompted an attempt at emergency shutdown; but a more extreme spike in power output led to the rupture of a reactor vessel and a series of explosions. The graphite moderator was exposed, causing it to ignite, and the resulting fire sent a plume of highly radioactive fallout over large parts of the western Soviet Union and Europe. From 1986 to 2000, 350 400 people were evacuated
and resettled from the most contaminated areas of Belarus, Russia and Ukraine. According to official post-Soviet data, about 57 % of the fallout landed in Belarus [1]. Chernobyl is widely considered to have been the worst nuclear accident in history and one of only two classified as a level 7 event on the International Nuclear Event Scale, the other being the Fukushima Daiichi nuclear meltdown in 2011 (see [2] Fukushima Nuclear Crisis, SiS 50).— From the beginning, the official nuclear safety experts were at pains to minimise the projected health impacts, as they are doing now for the Fukushima accident.  The UNSCEAR (United Nations Scientific Committee on the Effects of Atomic Radiation) estimated a “global collective dose” of radiation exposure from the accident “equivalent on average to 21 additional days of world exposure to natural background radiation”. Successive studies reported by the IAEA (International Atomic Energy Agency) continued to underestimate the level of exposure and to understate health impacts other than [3] “psychosocial effects, believed to be unrelated to radiation exposure” resulting from the lack of information immediately after the accident, “the stress and trauma of compulsory relocation to less contaminated areas, the breaking of social ties and the fear that radiation exposure could cause  health damage in the future.”——The number of deaths attributed to Chernobyl varies widely [1]. Thirty-one deaths are directly attributed to the accident, all among the reactor staff and emergency workers. An UNSCEAR report places the total confirmed deaths from radiation at 64 as of 2008. The Chernobyl Forum [4] founded in February 2003 at the IAEA Headquarters in Vienna with representatives from IAEA and UN agencies including UNSCEAR, WHO,  the World Bank, and Belarus, Russia and Ukraine, estimates that the eventual death toll could reach 4 000 among those exposed to the highest levels of radiation (200 000 emergency workers, 115 000 evacuees and 270 000 residents of the most contaminated areas); the figure includes some 50 emergency workers who died of acute radiation syndrome, 9 children who died of thyroid cancer and an estimated total of 3950 deaths from radiation-induced cancer and leukemia. The Union of Concerned Scientists based in Washington in the United States estimates another 50 000 excess cancer cases among people living in areas outside the most contaminated, and 25 000 excess deaths. A Greenpeace report puts the figure at 200 000 or more. The Russian publication, Chernobyl, by scientists Alexey V. Yablokov, Vassily B Nesterenko, and Alexey V. Nesterenko, translated and published by the New York Academy of Sciences in 2009, concludes that among the billions of people worldwide who were exposed to radioactive contamination from the disaster, nearly a million deaths had already occurred between 1986 and 2004. Most of the deaths were in Russia, Belarus and Ukraine [5] (see Truth about Chernobyl, SiS 47). The report drew on thousands of published papers and internet and printed publications. Those publications and papers, written by leading Eastern authorities, were downplayed or ignored by the IAEA and UNSCEAR. These agencies minimised their estimates by several ploys including [6]—– Underestimating the level of radiation by averaging exposure over a large regions, such as an entire country; so high exposure doses and health statistics of the most contaminated areas are lumped together with the less and least exposed

– Ignoring internal sources of radiation due to inhalation and ingestion of radioactive material from fallout
– Using an obsolete and erroneous model of linear energy transfer due to external sources of ionising radiation
– Not counting diseases and conditions other than cancers
– Overestimating the natural background radiation; today’s ‘background’ has been greatly increased by discharges from nuclear activities including tests of nuclear weapons, use of depleted uranium, and uranium mining
– Suppressing and withholding information from the public.
Nevertheless, the devastating health impacts did not escape the notice of the hundreds of doctors, scientists and other citizens who had to bear witness to the deformities, sicknesses and deaths of exposed babies, children and adults in their care. -Diversity of health impacts and their global extent over generations to come Alexei Yablokov, distinguished academician of the Russian Academy of Sciences in Moscow, spoke at the Scientific and Citizen Forum on adioprotection – From Chernobyl to Fukushima, 11-13 May 2012 in Geneva [7]. He is adamant that the consequences of the Chernobyl disaster can be clearly demonstrated by comparing the states of people’s health in areas receiving different amounts of additional radiation following the accident, instead of one based on average effective dose calculated by the ICRP and UNSCEAR which underestimates the true levels of irradiation. For example, there is a clear difference in mortality rates between highly contaminated provinces and less contaminated provinces of Russia (see Figure 1).  Yablokov is lead author of a massive report, now in its third enlarged 2011 edition [8], which has collated all the available evidence.

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Estriol- Benefits

Estriol, an estrogen that has virtually been ignored by the mainstream medical community, is one of the three principal estrogens produced by the body. Estriol was originally thought to have little significance due to its weak estrogenic activity when compared with estrone and estradiol. Nonetheless, research has found that its weakness may very well be its strength. –Studies suggest that when the lower-potency estrogen, estriol, is administered topically, it does not increase the risk of hormone-dependent cancers of the breast or endometrium (uterine lining).1-3 However, having weaker estrogenic effects does not mean that estriol has none of the benefits that come with more potent estrogens. Studies suggest that estriol reduces symptoms of menopause, such as hot flashes and vaginal dryness, but with a better safety profile compared with more potent estrogens.1,4,5 This makes estriol a better choice for bioidentical hormone-replacement treatment regimes. –That is not all this ‘weak’ hormone is good for! Research suggests that estriol has benefits for bone density, heart health, multiple sclerosis, and postmenopausal urinary tract health.6-12 In this article, we will review the attributes of this ‘weaker’ estrogen, and why this estrogen is currently in the news.

F     The body naturally makes three estrogen hormones—estradiol, estrone, and estriol. Since estriol possesses the weakest estrogenic effects of the three, it has been largely overlooked by the medical community.

  • Many studies show that estriol offers a wealth of potential health benefits—without the dangers that sometimes accompany higher-potency estrogens and synthetic or horse-derived hormones.
  • Studies suggest that estriol helps relieve menopausal symptoms while benefitting bone and urinary tract health. Estriol may also help improve cardiovascular risk factors and even shows promise in reducing the brain lesions of multiple sclerosis.
  • The most reliable way to measure estriol levels is through 24-hour urine collection.
  • Despite abundant evidence to the contrary, the FDA has recently claimed that estriol is not safe. You can act now to help preserve consumers’ access to bioidentical hormones such as estriol by visiting http://www.homecoalition.org.

Fear of cancer prevents many women from restoring youthful hormone levels. When applied through the topical (transdermal) route, estriol is not associated with increased cancer risk. Other methods women can use to prevent hormone-related cancers include consuming regular amounts of vitamin D,  and Bioflavonoids, Tumeric,Rosemary,Parsley,Dandelion, Hawthorn Berry, Black tea and Black Tea extracts, Celery Root, regulating meat and high-fat dairy intake.—

Estriol and Hormone Replacement Therapy

In addition, several studies suggest that bioidentical estrogen has less health risk when given with low doses of bioidentical progesterone.26,27— if you are on hormone-replacement therapy (HRT) and have never heard of estriol, you might be wondering why not? Before the 1970s, estriol was thought to have significance only during pregnancy we saw the beginning of hormone-replacement therapy with patented equine estrogens such as Premarin® and synthetic progestins as found in Provera®. By the 1990s, one-third of menopausal women were taking Premarin®. Research uncovered the increased incidence of breast cancer, increased risk of blood clotting, and increased cardiovascular risk associated with the use of these horse-derived and synthetic hormones (used in combination in the patented medication Prempro®).13 The medical community began to wonder if using hormones from pregnant horses was such a good idea. In an effort to find a safer alternative, many patients and practitioners began looking into ‘natural’ hormone-replacement treatment using bioidentical hormones, which are identical to those produced naturally within the body. Bioidentical-hormone replacement was pioneered in the 1980s as a treatment for menopause by Dr. Jonathan Wright in Washington state. ——-Interest in estriol increased as it was discovered that estriol was safer than horse-derived and synthetic hormones in relation to cardiovascular health and potentially cancer risk. Unfortunately, many doctors have not adopted its use, and many bioidentical hormone-replacement regimes use only estradiol, a more potent estrogen
with increased associated risks.-
— The benefits of estriol may, in part, be explained by the mixed pro-estrogenic and anti-estrogenic effects of this interesting estrogen hormone. Scientists Melamed et al. investigated the mixture of stimulating and non-stimulating effects posed by estriol upon estrogen receptors. When estriol is given together with estradiol, the estradiol-specific stimulation to cells is decreased. This little-appreciated scientific fact helps to explain how estriol can reduce pro-carcinogenic effects of more powerful estrogens like estradiol. However, when estriol is given alone over a long period of time, it can produce a more complete pro-estrogenic effect, explaining why symptom relief is achieved when menopausal women take estriol.2 Experimental studies suggest that both estriol and tamoxifen (a synthetic anti-estrogen) have protective effects against radiation-induced cancer of the breast[U10] .14— Most of the research cited in this article used oral estrogen as the route of administration. However, for enhanced safety, topical estriol would be a better choice. Several studies have shown that transdermal estrogen confers less health risk as a route of administration than oral estrogen.3,21-25 Clinical experience of many doctors over the past 20-30 years suggests that transdermal estrogen is also more effective for some women. This is largely thought to be due to the ‘first-pass effect’—meaning that orally ingested drugs are often first metabolized in the liver, before having any activity in the body. Orally ingested estrogen hormones are among these drugs that are first metabolized in the liver before exerting their effects in the body. Physicians experienced in hormone replacement often observe that women treated with oral estrogens show high levels of estrogen metabolites in 24-hour urine specimens, suggesting that most of the orally ingested hormones are being excreted.———- In a prospective study funded by the US Army and performed at the Public Health Institute, Berkeley, California, researchers compared estriol levels during pregnancy with breast cancer incidence 40 years later. Results revealed that of the 15,000 women entered in the study, those with the highest levels of estriol relative to other estrogens during pregnancy had the lowest cancer risk. In other words, as the relative level of estriol increased during pregnancy, risk of breast cancer decreased 40 years later. In fact, women with the highest level of estriol during pregnancy had 58% lower risk for breast cancer compared with women who had the lowest serum estriol levels. The authors also noted that Asian and Hispanic women had higher estriol levels compared with other racial groups. Interestingly, Asian and Hispanic women have the lowest breast cancer rates. The authors concluded, “If confirmed, these results could lead to breast cancer prevention or treatment regimens that seek to block estradiol estrogen action using estriol, similar to treatment based on the synthetic anti-estrogen tamoxifen.”15 —In another study, Takahashi et al. studied the safety of estriol treatment for Menopausal symptoms. Fifty-three women with either surgically induced or natural menopause were given 2 mg of oral estriol/day for 12 months. Endometrial and breast assessments done with endometrial biopsy and breast ultrasound, respectively, found normal results in all women. The authors concluded that over a 12-month period, “estriol appeared to be safe and effective in relieving symptoms of menopausal women.”1—In one investigation, 52 postmenopausal women were given 2 mg, 4 mg, 6 mg, or 8 mg/day of oral estriol for six months. In all patients, vasomotor symptoms of menopause (such as hot flashes) were decreased. The most improvement was experienced by women taking the highest dose of 8 mg. There were no signs of endometrial hyperplasia confirmed by endometrial biopsy over the six-month treatment period. Mammograms were obtained on six of the patients who had mammary hyperplasia at the study’s outset, and no further changes were seen.8- Although the oral route of administration of estriol appears relatively safe over the short-term, the transdermal route is preferred for long-term use. For example, Weiderpass et al. found an increased risk of endometrial atypical hyperplasia and endometrial cancer with oral use of estriol, but not with transdermal estriol over at least a five-year period. Compared with no use of estriol, those who took oral estriol for at least five years had a significantly greater risk, compared with individuals who did not take any estriol. Women using topical estriol for at least five years did not have any increased risk.

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New protein study could shake up sports nutrition market-Or Kill It!

A study out this week could add a new player to the protein market that’s long been dominated by whey.–At the Experimental Biology meeting in San Diego on Monday, Blake Rasmussen, PhD, of the University of Texas Medical Branch, presented findings that show a blend of protein sources—50 percent casein, 25 percent whey, 25 percent soy—was superior to whey alone for prolonging muscle building and recovery after exercise.[U11] “Whey protein has been given considerable notice as the gold standard ingredient after exercise to enhance muscle growth,” Rasmussen said. “The main problem with whey is it’s fast digesting—the anabolic response in muscle is only about an hour. We wanted to prolong the anabolic response with other protein sources. We found muscle protein synthesis is elevated for a longer amount of time with a protein blend versus whey protein.”[U12] The combination of protein blends was determined in Rasmussen’s previous preclinical work with rats.–Soy, whey and casein protein are all absorbed at different rates during digestion[U13] . Whey protein is referred to as a “fast” protein because it is rapidly absorbed, between 30 and 60 minutes, Rasmussen said. Soy is an intermediate protein, taking between 60 and 120 minutes to digest. And casein is a slow protein, requiring between three and five hours to digest.-“The combination gives you a quick increase in protein synthesis, and it gets sustained,” said Rasmussen. “It’s a prolonged delivery to muscle that the muscles use for recovery.”-The double-blind, randomized clinical trial followed 19 young adults before and after ingestion of about 19 grams of protein from the blend or about 17.5 grams of whey protein alone.

“Your muscles don’t recover in 30 minutes. It takes at least 24 to 48 hours for your muscles to recover after a resistance exercise,” said Greg Paul, global marketing director for sports nutrition and weight management at Solae, a soy supplier that sponsored the study.[U14]

Not just for athletes anymore?—It was only five years ago when research showed that protein should be an important part of sports nutrition products. Before then, the game was typically provided by the likes of Gatorade-style drinks: with fast carbs and electrolytes such as potassium and sodium.–Whey became the go-to protein source in beverages because it quickly fed muscles. Whey also appears better than soy for producing muscle synthesis because of the presence in whey of the amino acid leucine, which has been shown to uniquely act as a stimulatory signal for muscle protein synthesis. But for athletes and weekend warriors alike, using a blend of protein sources that absorb in the body over time means muscles are being fed until the next meal.

The addition of soy is also important because of soy’s particular properties including as an antioxidant and as an anti-inflammatory, which are both key attributes in muscle building beyond anabolic[U15] effects.

And this could lead to the next great demographic for protein products: the elderly.–“Protein blends are useful for sports nutrition,” said Rasmussen, “but also for those interested in aging and maintaining muscle mass as we age. This could potentially be a great intervention for aging.”[U16] -To date, products targeting elderly nutrition with protein-centric value propositions are few and far between. The trend of aging baby boomers, coupled with research demonstrating the value of protein blends in maintaining muscle mass, ought to be of interest to marketers and product developers. [U17]

 

TOP D


[U1]Again Not Genetic as they perpetrate—but a preconditioning to create the anomaly intended—an experiment of control and dependency and debilitation

[U2]Disruptor of the endocrine system—then what happens when you add several different disruptors of the endocrine system? Sterilization!!

[U3]Imagine the duress our lineage will have as a result of the –soy poisoning—chemtrail poisoning-vaccination poisoning –genetically modified food poisoning-environmental—they will be beyond xenophobic and will be told they have a genetic disposition to XYZ infections or conditions or potential invasion from a pathogen specific to there DNA structure—all lies—a direct result of intervention of a evil kind causing this to occur in 3 generations

[U4]It would appear they would possibly chose as a direct result of those who also would have hade these inherited genes –further compounding the problem and  causing  more issues

[U5]A Binary attack to hit and violate at the same time causing a breakdown

[U6]How interesting —we have a GMM= genetically  modified malaria—doe that not make you go hmmmmm wonder how it got genetically enhanced to resist what once cured it !!?—Is it not interesting that we have a new species of Malaria now—apparently the old one was not killing people off fast enough so now the pharma’ have decided to make this  a better pathogen

[U7]WARNING WARNING—Understand this—Genetic Mutation–

[U8]Interesting—if they had the  money they could be relieved but no money and they are held hostage by the IMF—what a crock

[U9] 90% kill ratio—-am I the only one seeing this is not a natural cause—weoponized malaria??

[U10]Utilizing black tea in a concentrated form  has actually the same effect as tamoxifen without the unwanted side effects

[U11]You never Mix a casein with a Soy they are highly allergenic and will cause all kinds of intestinal break down–The soy itself is an idigestible protein that cause intestinal and pancreatic cancers—avoid this

[U12]This is true—but the issue is how it is blended—the idea that you can mix a good egg or animal protein wih the whey would make this far superior to there method and without the allergens associated  with the Soy

[U13]This is true whey is in and out in about 2 hours casein in and out in about 4-6 hours-Soy can take a month due to the fact it does not digest and in fact causes intestinal disruptions and pancreatic shutdown—so they are right in the blending but wrong in how they blend

[U14]NOW YOU SEE WHO DID THE STUDY- A CONFLICT OF INTREREST SINCE THEY  TRIED TO PATENT SOY-AND THE ISRAELI GOV’T STOPPED THEM FROM ATTAINING THIS AND IN FACT GAVE SOME OF THE HARSHEST CRITIQUE ON SOY AND WHO COULD EAT IT—ESSENTIALLY NO ONE BASED ON THOSE STUDIES

[U15]This is at  best  a fabrication go to the soy links at http://augmentinforce.50webs.com

and read for your self the 4 studies that are there—even the FDA since 1904  knew Soy was toxic and not meant to consume

[U16]If this is followed this will exacerbate an already compromised colon and or pancreas—this advice Should not be followed at all—this was obviously done by someone trying to get ahead at the elderly expense

[U17]This is a form of  euphanasia—food poisoning the elderly

Posted in The Remedy Show notes, Tony Pantellresco's Articles, Uncategorized | Leave a comment

Show Of The Week June 11 2012

Understanding Why Alkalinity Can Be Unhealthy

 

Bt Toxin Kills Human Kidney Cells

 

Green Tea Compound for Radioprotection

 

2 people dead after swarms of venomous spiders invade Indian town

 

Polyphenolics from various extracts/fractions of red onion (Allium cepa) peel with potent antioxidant and antimutagenic activities

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Understanding Why Alkalinity Can Be Unhealthy

If you took high school or college chemistry, you may remember that pH is a measure of the acidity or alkalinity of a solution. The pH scale ranges from 0 to 14 with 7 for neutral solutions [white, middle of scale] with:

  • Lower numbers representing increased acidity [red zone, top of scale at right]
  • Higher numbers representing increased alkalinity and [blue zone, bottom of scale at right]

In an overly alkaline environment [due to aliens closeby in Earth’s 4th dimension — aliens whose energy is highly alkaline], there is a need for the following strategies:

  • Emphasize acid-forming foods
  • Use white vinegar in bath water and washing machine [2 –  to 9 cups] depending on the severity of the alkaline energy.
  • Use soaps that have a neutral pH [e.g. glycerin soap] or contain mild acid that help preserve the skin’s acid mantle [e.g. goat milk soap]. Note: Miracle II is a pH neutral soap that is available through mail-order distributors and some retail stores.

Acids and alkalines (also known as bases) neutralize each other forming salt and water. By emphasizing acids in your diet and on your skin, you will neutralize the extreme alkaline energy that is all around us [due to the presence of aliens]. I will explain more details about these concepts later in this article.

Why Does Alkalinity Cause Aging? The key to why alkalinity causes aging is in the definition of acids and bases that was developed by a scientist named Svante August Arrhenius (1859 – 1927): –An acid is a substance that increases the concentration of hydrogen ions (H+), which are carried as hydronium ions (H3O+) when dissolved in water, while bases are substance that increase the concentration of hydroxide ions (OH-). –Hydrogen ions are involved in growth (a daytime function). They’re also needed in the body to convert adenosine diphosphate (ADP) to adenosine triphosphate (ATP). ATP has been called the “energy currency” of the cell. —The illustration Below shows a high concentration of hydrogen ions (H+) that are needed for growth and the production of energy used in the human body. See: “Selecting Foods That Provide Hydrogen Ions.” A substance with a high concentration of hydrogen ions would be extremely acid showing little or no hydroxide ions.–In contrast, the illustration at right shows a high concentration of hydroxide ions that are present in alkaline substances. Hydroxide ions will slow growth and thwart metabolic processes in the body because they gobble hydrogen ions to form salt and water [setting up a condition for accelerated aging].–A substance with a high concentration of hydroxide ions would be extremely alkaline showing little or no hydrogen ions.

Food Lies When you read what foods provide hydrogen ions for growth and energy production, you’ll say: —Hey, wait a minute, is there an extermination agenda? It turns out, most of the health advice we’re given is false. Examples include:

  • [#1] Alkaline-forming foods are healthy [fruits and vegetables] and acid-forming foods are harmful.

The truth: Alkaline-forming foods [and energy] cause accelerated aging and promote the growth of parasites that cause disease [Note: If energy was more normal, fruits and vegetables would provide a balance].

  • [#2] Fat is bad and low- fat or no-fat is healthy [Note: It has become almost impossible to find whole milk products in food stores and children are being fed low-fat dairy in schools.

The truth: Half of every cell wall is made of saturated fat, the fat that we’re told not to eat. With decreased energy and not enough fat to make new cells, you can imagine the effect these two combined factors have on aging. Children need fat for brain development. In addition, fat is required to make hormones. Infertility rates are very high.

These ideas are so deeply embedded, they’re hard to dislodge. Aren’t all the sources of information providing the same information? That’s right — they are.

 

Selecting Foods That Provide Hydrogen Ions Selecting foods that provide hydrogen ions can be tricky because the key is to select foods leave minerals behind that the body can use to make acids.

Some foods, such as lemons, seem to contain an acid (citric acid), yet they do not leave the minerals behind to make acids.–To correct mistakes that you may be making — will require memorization. I recommend Herman Aihara’s book that is shown in the upper left corner of this page [some authors make mistakes concerning acid- forming and alkaline forming]. –Look closely at the following chart and notice what foods we’re told to eat and not eat:

Acid-forming Minerals Alkaline-forming Minerals
Chloride (makes hydrochloric acid) Magnesium (makes magnesium hydroxide)
Phosphorus (makes phosphoric acid) Calcium (makes calcium hydroxide)
Sulfur (makes sulfuric acid) Potassium (makes potassium hydroxide)
Acid-forming Foods Alkaline-forming Foods
Apple Cider Vinegar (strong) Citrus Fruit (strong)
Peanut Butter (strong) Green Vegetables (strong)
Chocolate (strong) Seaweed (strong)
Meat (medium) Green Tea (strong)
Bread (medium) Sea Salt (medium)
Eggs (medium) Coffee (medium)
Black tea (medium) Wine (medium)
Milk and Cheese (Weak) Ginger (Medium)

Dr. Carey Reams: Parasites Thrive in Alkalinity Dr. Carey Reams [1904-1985], a medical doctor who also had a career as a soil scientist, has a devoted following in modern agricultural circles that could be described as alternative. Just as there are alternative medical doctors who strive to heal the body without drugs, there are farmers who prefer to use natural methods instead of chemicals.–In the area of human health, Reams is most known for an ionization theory that consists of seven mathematical equations that provide a framework for balancing the body’s chemistry. The equations are referred to as Reams Biological Theory of Ionization [RBTI] and pH was an important aspect of Reams’ work.—During his lifetime, Reams  taught workshops, but was too busy avoiding the medical establishment to write his own books. Fortunately, an oral surgeon named Dr. Alexander Beddoe, has written several books about Reams’ work. –Dr. Beddoe’s RBTI text book lists the following health conditions that are due to alkalinity:

Parasites
Acne Arthritis Slow digestion Breakdown of discs in the back Body odor Deminerialization of bones Dental decay
Ear deterioration Fever Gall stonesHeart stress Hot flashes Lower GI gas Mental confusion Moody/depression Muscle soreness Increase in skin pigmentation

If alkalinity reflects an abundance of hydroxide ions, this may lead to a buildup of excess water in the body. When a hydroxide ion encounters a hydrogen ion [a base meeting an acid], there is a neutralization reaction that forms salt and water. If you add the popular health advice to eat alkaline-forming foods [fruits and vegetables], and the fact that hydrogen ions [from acid-forming foods] are required for metabolism-driving energy, I believe that acid-base chemistry is the reason that many businesses are selling very large products.

Hydrochloric Acid Kills Parasite Eggs Disease-causing parasites are the most serious result of the alkalinity problem. The solution is to make the body inhospitable to parasites using food chemistry and herbs.—Chloride, the mineral that’s needed to make hydrochloric acid, provides an example of why we need to be careful when selecting the foods that we eat. You’ll notice that chloride is a mineral that is needed to make hydrochloric acid [that kills parasite eggs in the stomach]. This mineral is left behind by acid-forming foods [that we’re told not to eat]. –Parasites that cause disease lay eggs that are very small. If the eggs are present in food and if we have enough hydrochloric acid, the eggs will not mature and cause health problems.—Alkaline-forming foods create an environment in the body that is very healthy for parasites.—To neutralize alkaline energy, I drink apple cider vinegar in ice water, drink mostly black tea and I eat a lot of peanut butter. Peanut butter is also rich in nutrition [26 minerals, 14 vitamins and monounsaturated fat that’s used for energy and converted to saturated fat as needed].

Killing Large Parasites Dr. Hulda Clark [1928-2009], who wrote The Cure and Prevention of All Diseases, discovered herbs that kill large parasites. —Because there are no lab tests for large parasites that cause serious diseases such as cancer and heart disease, most medical doctors are clueless about the connection between parasites and disease.–Hulda was a meticulous researcher and she made a great contribution. The following list of herbs form the foundation of a group of herbs that Hulda wrote about for fifteen years. See: Antiparasite Tea Recipe

Herb Action
Cloves Hydrochloric acid (HCL) in the stomach kills parasite eggs. If stomach acid is low, the eggs may survive. Cloves are known to kill:

• Parasite eggs • Pseudomonas aeruginosa • Staphylococcus • Streptococcus • Malaria • Tuberculosis • Cholera • Scabies • Candida • Shigella

Black Walnut [Green] Hull Tincture Kills adult parasites and developmental stages. This tincture contains organic iodine that is required by every cell in the body. The green hull around the nut of the black walnut has antiparasitic properties.
Wormwood (Artemesia absinthium) Wormwood works to anesthetize worms so they detach from body tissues. It is most effective against roundworms, hookworms, whipworms and pinworms.
Thyme Thyme kills hook-worms, roundworms, threadworms and skin parasites. Thyme also destroys Cryptococcus neoformans, Aspergillus, Saprolegnia, Salmonella typhimurium, Staphylococcus aureas, and Escherichia coli.

Antiparasite Tea Recipe Hulda’s basic herbs are Cloves, Black Walnut Hull Tincture, and Wormwood. I make tea using the following recipe [frequently].

2-3 Cups of Water 2-3 Tea Bags Black Tea [e.g. Earl Grey] 48 Drops of Black Walnut Hull Tincture 12 Drops of Wormwood Tincture 1/4 teaspoon of Ground Cloves (approximately) 2-3 Sprigs of Fresh Thyme

  1. Use Distilled or Reverse Osmosis If you have a weak immune system, you may want to purchase Hulda’s book and learn how to sterilize food — with a freezer or sound waves. Chest freezers that can be set to -20 degrees kill parasites and microorganisms in 24 hours. — I use sound waves generated by a jewelry cleaner that Hulda renamed a “sonicator.” The Haier Jewelry Cleaner has a 25 oz. water tank (HDPE bottles of herbs are submerged to apply sound waves). Jewelry cleaners kill bugs in 20 minutes [$29.99 at Amazon.com].

A jewelry cleaner tank can accomodate two Nalgene, four-ounce, wide-mouth HDPE bottles containing loose herbs [available at camping stores such as REA or Eastern Mountain Sports].

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Bt Toxin Kills Human Kidney Cells

Cry1Ab biopesticide kills human cells at low doses as does Roundup herbicide Dr Eva Sirinathsinghji
A new study shows that low doses of Bt biopesticide CryA1b as well as the glyphosate herbicide, Roundup, kill human kidney cells. The Bt biopesticide conferring insect resistance and the glyphosate tolerance trait tied to the use of glyphosate herbicides account for almost all the GM crops grown worldwide. Bt crops already constitute 39 % of globally cultivated genetically modified (GM) crops, yet this is the first study that provides evidence on the toxicity of Bt protein in human cells.  This work comes at a time when the French environment and agricultural ministers are seeking an EU-wide ban of Monsanto’s MON810 Bt corn variety that is already outlawed in Hungary, Austria, Germany, Greece, and Luxembourg[U1] . The EU commission approved this crop in 2009, concluding that it “is as safe as its conventional counterpart with respect to potential effects on human and animal health”. In response to their publication the research team raised questions about the safety assessment procedure stating that their findings were a “surprising outcome and this risk was somehow overlooked” in past assessments of such crops. [1]. — The research team led by Gilles-Eric Séralini at the University of Caen, France, is already well-known for their investigations on the endocrine disrupting effects of glyphosate herbicides (see [2] Glyphosate Kills Rat Testis Cells[U2] , SiS 54).The researchers tested the effects of Cry1Ab and Cry1Ac proteins as well as their combined effects with the herbicide Roundup on the human kidney cell line HEK293 [3]. Humans are exposed to hundreds of chemicals in a day, and their combined effects need to be understood. This is particularly important when considering the new generation of ‘stacked’ genetically modified (GM) crops now on the market, which carry multiple resistance genes for Bt toxins and glyphosate tolerance together. [U3] ———Experiments were performed to assess both cell death and cell membrane integrity, as the pesticidal activity of Bt toxins results from creating pores in the membrane of cells in the insect gut. Cell death was measured using three parameters: 1) mitochondrial succinate dehydrogenase enzyme activity as a general cell death marker, 2) activity of the membrane-bound enzyme adenylate kinase  (AK) to assess membrane integrity as a marker of necrotic cell death and 3) caspase 3/7 activity, as a marker of apoptosis (programmed cell death). They found that Cry1Ab caused cell death at concentrations of 100 parts per million (ppm), according to mitochondrial succinate dehydrogenase activity. The membrane-bound enzyme adenylate kinase (AK) goes up in activity when the membrane disintegrates and releases the enzyme into the culture medium. Cry1Ab at 100 ppm induced a 2-fold increase in AK activity. No effects were seen with Cry1Ac.

 

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Antidiabetic potentials of Momordica charantia: multiple mechanisms behind the effects.

J Med Food. 2012 Feb;15(2):101-7–Authors: Chaturvedi P

Abstract Momordica charantia fruits are used as a vegetable in many countries. From time immemorial, it has also been used for management of diabetes in the Ayurvedic and Chinese systems of medicine. Information regarding the standardization of this vegetable for its usage as an antidiabetic drug is scanty. There are many reports on its effects on glucose and lipid levels in diabetic animals and some in clinical trials. Reports regarding its mechanism of action are limited. So in the present review all the information is considered to produce some concrete findings on the mechanism behind its hypoglycemic and hypolipidemic effects. Studies have shown that M. charantia repairs damaged β-cells, increases insulin levels, and also enhance the sensitivity of insulin. It inhibits the absorption of glucose by inhibiting glucosidase and also suppresses the activity of disaccharidases in the intestine. It stimulates the synthesis and release of thyroid hormones and adiponectin and enhances the activity of AMP-activated protein kinase (AMPK). Effects of M. charantia like transport of glucose in the cells, transport of fatty acids in the mitochondria, modulation of insulin secretion, and elevation of levels of uncoupling proteins in adipose and skeletal muscles are similar to those of AMPK and thyroxine. Therefore it is proposed that effects of M. charantia on carbohydrate and fat metabolism are through thyroxine and AMPK.—PMID: 22191631 [PubMed – indexed for MEDLINE][U4]

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Green Tea Compound for Radioprotection
Green tea polyphenol antioxidant protects against bystander effects of low dose ionizing radiation that damage cells and cause numerous diseases including cancer. Dr. Mae-Wan Ho–The recent discovery of bystander effects from low levels of ionizing radiation has thrown risk assessment and radioprotection into disarray [1] (Bystander Effects Multiply Dose and Harm from Ionizing Radiation, SiS 55). However, it has also led to the discovery of potential mitigating measures against exposure to radioactivity, especially from nuclear accidents like Chernobyl (and Fukushima), the devastation health impacts of which are still surfacing 25 years later [2] (Chernobyl Deaths Top a Million Based on Real Evidence. SiS 55). ——Ionizing radiation has been known to produce free radicals and reactive oxygen species (ROS), predominantly by ionizing water, the most abundant molecules in tissues and cells (see [1] for an explanation of ROS). ROS are responsible for oxidative damage to DNA, proteins, and lipids, initiating cell death, genomic instability and other consequences of radiation, both in cells that have been directly targeted, and in bystander cells that have not been irradiated [1]. There is evidence that various antioxidants can protect cells against bystander radiation damages, and new findings published online in Mutation Research appear particularly promising. —-shu Tiku and Benila Richi at Jawaharlal Nehru University, New Delhi and Roasaheb Kale at Central University of Gujarat in India may have found the ideal antioxidant for radioprotectopm [3].
Non-toxic compound needed for radioprotection—–One main problem in radioprotection is to find compounds that are non-toxic or minimally so, and natural compounds fit the bill in being both non-toxic and easily available.  Green tea is a rich source of polyphenols with strong antioxidant activities. Green tea extracts and its polyphenols have been shown to possess many health benfits attributed to their antioxidant and anti-inflammatory properties (see [4, 5] Green Tea, The Elixir of Life? and Green Tea Against Cancers, SiS 33). Most of the health benefits of green tea have been credited to the major polyphenol EGCG (epigallocatechin-3-gallate) which constitutes 55 – 70 % of total polyphenols in green tea extract. Its antioxidant potential is believed to be far greater than vitamin E and vitamin C, the two main antioxidants among vitamins [6]. The team exposed both pBR322 plasmid DNA as well as spleen cells from mice to g-radiation at different concentrations of EGCG. Preliminary experiments found that EGCG concentrations above 125 mM were toxic to the cells, so the highest concentration used was restricted to 100 mM. The effects of quercetin – another polyphenol found in fruits, vegetables, leaves and grains – and vitamin C were also investigated. The plasmid DNA and cells were incubated for 2 hours with EGCG at different concentrations or quercetin and vitamin C, both at 100 mM, before being irradiated. Afterwards, the plasmid and cells were assessed for DNA damage, and the cells for viability, lipid peroxidation, membrane fluidity, and for activities of enzymes and cofactors involved in detoxification and scavenging of ROS.  Tea compound protects against DNA breaks and cell death–The intact plasmid is supercoiled in a compact form, while the cut plasmid is circular, and the two forms can be clearly distinguished and quantified by electrophoresis. The control (unexposed) sample is about 85% supercoiled. EGCG was found to protect plasmid DNA against breaks at high (50 Gy) or low (3 Gy) dose radiation: >82.5 % protection even at the lowest concentration of EGCG tested (10 mM) and complete 100 % protection at 50 mM. EGCG was better at protection against DNA breaks than quercetin or vitamin C at the same concentration of 100 mM. The viability of cells was determined with a vital dye that depends on active mitochondria.  At 3 to 7 Gy of g-irradiation, cell viability was significantly decreased, and at the highest dose, to 53 % of unexposed controls; but pre-incubation with EGCG protected the cells and restored viability in a concentration dependent manner, at 100 mM, viability was restored to >96 % of control. Single cell comet assay was used to determine the extent of DNA degradation in the cells. In this assay, cells are trapped in agar gel on a microscope slide, lysed to expose their DNA for electrophoresis, and stained with a fluorescent dye. Cells with intact DNA will appear as a small compact bright spot, while cells with degraded DNA will appear as a diffuse spot with a tail, like a comet, hence the name of the assay.  The bigger the tail, the greater is the extent of degradation, which can be quantified with computer software under a fluorescent microscope. Exposing the cells to 3 Gy led to substantial DNA degradation, which was reduced in a concentration dependent manner by EGCG. Quercetin and vitamin C -also protected the cells against DNA damage, though not as effectively as EGCG.

 

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2 people dead after swarms of venomous spiders invade Indian town

( Playing with genetics- )–Published June 03, 2012

SADIYA, India –  A town in India has suddenly been overrun by swarms of venomous spiders, leaving two people dead after being bitten.–It may sound like a B-grade horror movie, but residents of the town of Sadiya, in Assam state, say that on the evening of May 8 as they were celebrating a Hindu festival swarms of spiders suddenly appeared and attacked them, The Times of India reported.—Over the next few days two people — a man, Purnakanta Buragohain, and an unnamed school boy — died after being bitten by the spiders. Scores more turned up at the town’s hospital with spider bites.–Local resident Jintu Gogoi spent a day in the hospital complaining of excruciating pain and nausea after being bitten. He said weeks later his finger was still blackened and swollen.—District authorities are also panicking — and they are considering spraying the town with the insecticide DDT.—Locals say the most terrifying aspect is that spiders appear in swarms and their behavior is highly aggressive.[U5] –“It leaps at anything that comes close. Some of the victims claimed the spider latched on to them after biting. If that is so, it needs to be dealt with carefully. The chelicerae and fangs of this critter are quite powerful,” head of the department of life sciences at Dibrugarh University Dr. L.R. Saikia said.–Teams of Indian arachnid experts have flocked to the town, hoping to identify the species, but so far they have drawn a blank.[U6] They say it could be a tarantula, a black wishbone or even a funnel-web spider — or it could be a whole new species.—One thing they agree on is that it is not native to the area as there is no record of venomous spiders in Assam. The black wishbone and funnel-web are native to Australia. Researchers are also still running tests to find out the toxicity of the spiders’ venom.–Dr. Anil Phatowali, superintendent of the town’s hospital, said they had not administered antivenin as they could not be certain the spider was venomous at all.—He also pointed out other factors may have contributed to the two reported fatalities.–“All the bite patients first went to witch doctors, who cut open their wounds with razors, drained out blood and burnt it. That could have also made them sick,” Phatowali said.

Read more: http://www.foxnews.com/world/2012/06/03/2-people-dead-after-swarms-venomous-spiders-invade-indian-town/print#ixzz1wmE3t1TL

 

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Polyphenolics from various extracts/fractions of red onion (Allium cepa) peel with potent antioxidant and antimutagenic activities.

Singh BN, Singh BR, Singh RL, Prakash D, Singh DP, Sarma BK, Upadhyay G, Singh HB.

Source

Nutraceutical Chemistry, National Botanical Research Institute, Lucknow 226 001, India.

Abstract

In order to determine antioxidant activity, the five extracts/fractions of red onion peel were studied for their total content of phenolics (TPC), flavonoids (TFC), antioxidant activity (AOA), free radical scavenging activity (FRSA), assayed by DPPH radical in the terms of anti-radical power (ARP) and reducing power (RP), expressed as ascorbic acid equivalents (ASE)/ml. High TPC (384.7 +/- 5.0 mg GAE/g), TFC (165.2+/- 3.2 mg QE/g), AOA (97.4 +/- 7.6%), ARP (75.3 +/-4.5) and RP (1.6 +/-0.3 ASE/ml) were found for the ethyl acetate (EA) fraction. EA fraction had markedly higher antioxidant capacity than butylated hydroxytoluene (BHT) in preventive or scavenging capacities against FeCl3-induced lipid peroxidation, protein fragmentation, hydroxyl (site-specific and non-site-specific), superoxide anion and nitric oxide radicals. EA fraction also showed dose dependent antimutagenic activity by following the inhibition of tobacco-induced mutagenicity in Salmonella typhimurium strains (TA102) and hydroxyl radical-induced nicking in plasmid pUC18 DNA. HPLC and MS/MS analysis showed the presence of ferulic, gallic, protocatechuic acids, quercetin and kaempferol. The large amount of polyphenols contained in EA fraction may cause its strong antioxidant and antimutagenic properties. This information shows that EA fraction of red onion peel can be used as natural antioxidant in nutraceutical preparations.

 

 

TOP C


[U1]Observe these countries who have rejected this GMO—watch them all go financially broke—or economically devastated—germany is broke from bailing out half of Europe and Greece is totally in economic ruin—keep your eye on the other countries and watch them become devastated

[U2]Apparently this is what is going on with the  Human Race as well

[U3]And you wonder why you have headaches—endocrinal disruptions-heart issues-skin issues-brain issues—thyroid and liver and lung issues-glandular issues-why you seem to be aging far more rapidly then you should—why you are having difficulty in things you should not be having especially at the ages of the mid 20’s to 40 and upward ( downward if you are afflicted )

[U4]SO this maybe  good to take with tyrosine and iodne as welll

[U5]Genetically Modified Spider?—is it possible after all these years of planting a genetic disrupting compounds into the earth that we have finally made a genetically aggressive species—Was it done in a lab and now this particular area was or is being targeted!!!

[U6]A BLANK!!!!!so is it an alien specied fallen off a space ship—is it a lab made spider—is it been genetically changed due to either experimentation or careless dumping of genetic  materials—and no hypothesis?? A blank—something smells bad and it ain’t socks off a sweaty feet!!

Posted in Remedies, The Remedy Show notes, Tony Pantellresco's Articles, Uncategorized | Leave a comment

Show of the Week June-8-2012

 

Epigallocatechin-3-gallate is a new inhibitor of hepatitis C virus entry.

 

Antiviral effects of ascorbic and dehydroascorbic acids in vitro

 

The effect of black tea on risk factors of cardiovascular disease in a normal population

 

Black tea reduces uric acid and C-reactive protein levels in humans susceptible to cardiovascular diseases

 

Black tea polyphenols inhibit tumor proteasome activity

 

Black tea polyphenol theaflavins inhibit aromatase activity

 

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(-)-Epigallocatechin-3-gallate is a new inhibitor of hepatitis C virus entry.

Hepatology. 2012 Mar;55(3):720-9

Authors: Calland N, Albecka A, Belouzard S, Wychowski C, Duverlie G, Descamps V, Hober D, Dubuisson J, Rouillé Y, Séron K

Here, we identify (-)-epigallocatechin-3-gallate (EGCG) as a new inhibitor of hepatitis C virus (HCV) entry. EGCG is a flavonoid present in green tea extract belonging to the subclass of catechins, which has many properties. Particularly, EGCG possesses antiviral activity and impairs cellular lipid metabolism. Because of close links between HCV life cycle and lipid metabolism, we postulated that EGCG may interfere with HCV infection. We demonstrate that a concentration of 50 μM of EGCG inhibits HCV infectivity by more than 90% at an early step of the viral life cycle, most likely the entry step. This inhibition was not observed with other members of the Flaviviridae family tested. The antiviral activity of EGCG on HCV entry was confirmed with pseudoparticles expressing HCV envelope glycoproteins E1 and E2 from six different genotypes. In addition, using binding assays at 4°C, we demonstrate that EGCG prevents attachment of the virus to the cell surface, probably by acting directly on the particle. We also show that EGCG has no effect on viral replication and virion secretion. By inhibiting cell-free virus transmission using agarose or neutralizing antibodies, we show that EGCG inhibits HCV cell-to-cell spread. Finally, by successive inoculation of naïve cells with supernatant of HCV-infected cells in the presence of EGCG, we observed that EGCG leads to undetectable levels of infection after four passages. CONCLUSION: EGCG is a new, interesting anti-HCV molecule that could be used in combination with other direct-acting antivirals. Furthermore, it is a novel tool to further dissect the mechanisms of HCV entry into the hepatocyte.—PMID: 22105803 [PubMed – indexed for MEDLINE]

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Antiviral effects of ascorbic and dehydroascorbic acids in vitro.

Furuya A, Uozaki M, Yamasaki H, Arakawa T, Arita M, Koyama AH.

Source–Department of Cellular and Molecular Medicine, Wakayama Medical University Graduate School of Medicine, Wakayama 641-8509, Japan.

In the present study, ascorbic acid weakly inhibited the multiplication of viruses of three different families: herpes simplex virus type 1 (HSV-1), influenza virus type A and poliovirus type 1[U1] . Dehydroascorbic acid, an oxidized form of ascorbic acid and hence without reducing ability, showed much stronger antiviral activity than ascorbic acid, indicating that the antiviral activity of ascorbic acid is due to factors other than an antioxidant mechanism. Moreover, addition of 1 mM Fe3+, which oxidizes ascorbic acid to dehydroascorbic acid and also enhances the formation of hydroxyl radicals by ascorbic acid in the culture media, strongly enhanced the antiviral activity of ascorbic acid to a level significantly stronger than that of dehydroascorbic acid. Although both ascorbic acid and dehydroascorbic acid showed some cytotoxicity, the degree of cytotoxicity of the former was 10-fold higher than the latter, suggesting that the observed antiviral activity of ascorbic acid with and without ferric ion is, at least in part, a secondary result of the cytotoxic effect of the reagent, most likely due to the free radicals. However, the possibility that oxidation of ascorbic acid also contributed to the antiviral effects of ascorbic acid exists, in particular in the presence of ferric ion, since dehydroascorbic acid exhibited a very strong antiviral activity. Characterization of the mode of antiviral action of dehydroascorbic acid revealed that the addition of the reagent even at 11 h post infection almost completely inhibited the formation of progeny infectious virus in the infected cells, indicating that the reagent inhibits HSV-1 multiplication probably at the assembly process of progeny virus particles after the completion of viral DNA replication.

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Benefits of Black Tea

 

The effect of black tea on risk factors of cardiovascular disease in a normal population.

Bahorun T, Luximon-Ramma A, Neergheen-Bhujun VS, Gunness TK, Googoolye K, Auger C, Crozier A, Aruoma OI.

Source-ANDI Centre of Excellence for Biomedical and Biomaterials Research, CBBR Building, MSIRI, University of Mauritius, Réduit, Republic of Mauritius.

OBJECTIVES-A prospective randomized controlled clinical trial determined the effect of Mauritian black tea consumption on fasting blood plasma levels of glucose, lipid profiles and antioxidant status in a normal population.

METHODS-The study group (71%) consumed 3 x 200ml of black tea infusate/day for 12weeks without additives followed by a 3week wash-out. The control group (29%) consumed equivalent volume of hot water for same intervention period.

RESULTS–The tea used had high levels of gallic acid derivatives (50±0.4mg/L), flavan-3-ols (42±2mg/L), flavonols (32±1mg/L) and theaflavins (90±1mg/L). Daily 9g supplementation of black tea infusate induced, in a normal population, a highly significant decrease of fasting serum glucose (18.4%; p<0.001) and triglyceride levels (35.8%; p<0.01), a significant decrease in LDL/HDL plasma cholesterol ratio (16.6%; p<0.05) and a non significant increase in HDL plasma cholesterol levels (20.3%), while a highly significant rise in plasma antioxidant propensity (FRAP: 418%; p<0.001) was noted .

CONCLUSION-Black tea consumed within a normal diet contributes to a decrease of independent cardiovascular risk factors and improves the overall antioxidant status in humans.

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Black tea reduces uric acid and C-reactive protein levels in humans susceptible to cardiovascular diseases.

Bahorun T, Luximon-Ramma A, Gunness TK, Sookar D, Bhoyroo S, Jugessur R, Reebye D, Googoolye K, Crozier A, Aruoma OI.

Source–Department of Biosciences, Faculty of Science, University of Mauritius, Réduit, Mauritius. tbahorun@uom.ac.mu

The effect of black tea on the level of uric acid (UA) and C-reactive proteins (CRP) in humans susceptible to ischemic heart diseases was assessed in a prospective randomized controlled study. The study group consumed 9 g of black tea (equivalent to three cups of tea) daily for 12 weeks without additives followed by a 3-week wash-out (with control group consuming equivalent volume of hot water). Black tea consumption induced a highly significant decrease in the high uric acid baseline groups > 6 mg/dL by 8.5%; p < 0.05. For men and women in the base line group > 7 mg/dL, the decrease was 9.4% and 7.1%, respectively. In the low baseline serum uric acid levels there was a non-significant increase of 3.7% and 15% in men and women, respectively. C-reactive protein in the high risk group > 3mg/L was significantly decreased by 53.4% and 41.1% in men and women, respectively. For the non-supplemented group in this range the changes were 3.7% decrease for men and 2.9% increase for women. Tea supplementation-associated decrease in plasma uric acid and C-reactive protein levels may benefit humans at high risk of cardiovascular events and may augment drug therapy.–

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Black tea polyphenols inhibit tumor proteasome activity.

Mujtaba T, Dou QP.

Source

The Developmental Therapeutics Program, Barbara Ann Karmanos Cancer Institute and Department of Oncology, School of Medicine, Wayne State University, Detroit, MI 48201-2013, USA.

Abstract

Tea is a widely consumed beverage and its constituent polyphenols have been associated with potential health benefits. Although black tea polyphenols have been reported to possess potent anticancer activities, the effect of its polyphenols, theaflavins on the tumor’s cellular proteasome function, an important biological target in cancer prevention, has not been carefully studied. Here black tea extract (T5550) enriched in theaflavins inhibited the chymotrypsin-like (CT) activity of the proteasome and proliferation of human multiple myeloma cells in a dose-dependent manner. Also an isolated theaflavin (TF-1) can bind to, and inhibit the purified 20S proteasome, accompanied by suppression of tumor cell proliferation, suggesting that the tumor proteasome is an important target whose inhibition is at least partially responsible for the anticancer effects of black tea.

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Black tea polyphenol theaflavins inhibit aromatase activity and attenuate tamoxifen resistance in HER2/neu-transfected human breast cancer cells through tyrosine kinase suppression.

Way TD, Lee HH, Kao MC, Lin JK.

Source

Institute of Biochemistry and Molecular Biology, College of Medicine, National Taiwan University, No. 1, Section. 1, Jen-Ai Road, Taipei 10018.

Abstract

The aromatase enzyme, which converts androstenedione to oestrone, regulates the availability of oestrogen to support the growth of hormone-dependent breast tumours. In this study, we investigated the inhibitory effects of black tea polyphenols on aromatase activities. We found that black tea polyphenols, TF-1, TF-2 and TF-3, significantly inhibited rat ovarian and human placental aromatase activities. In addition, using an in vivo model, these black tea polyphenols also inhibited the proliferation induced by 100 nM dehydroepiandrosterone (DHEA) in MCF-7 cells. Transfection of HER2/neu in MCF-7 breast cancer cells appeared to be associated with an increased resistance of the cells to hormonal therapy. Interestingly, unlike the selective oestrogen receptor modulator (SERM) tamoxifen, black tea polyphenols had antiproliferation effects in breast cancer cells with hormonal resistance. The inhibitory effect of black tea polyphenols on hormone-resistant breast cancer cells suppressed the basal receptor tyrosine phosphorylation in HER2/neu-overexpressing MCF-7 cells. These findings suggest the use of black tea polyphenols may be beneficial in the chemoprevention of hormone-dependent breast tumours and represent a possible remedy to overcome hormonal resistance of hormone-independent breast tumours.

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TOP B


[U1]This would be dose dependent the stronger the dose the higher the success

 

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Show of the Week June 4-2012

Cinnamon extract promotes type I collagen biosynthesis via activation of IGF-I signaling in human dermal fibroblasts

 

Hazelnuts- New Source of Key Fat for Infant Formula That’s More Like Mother’s Milk

 

Selenium and CoEnzyme Q 10

 

Commonly Used Pesticide Turns Honey Bees Into ‘Picky Eaters’

 

Persistent Sensory Experience Is Good for Aging Brain

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Cinnamon extract promotes type I collagen biosynthesis via activation of IGF-I signaling in human dermal fibroblasts.

J Agric Food Chem. 2012 Feb 8;60(5):1193-200–Authors: Takasao N, Tsuji-Naito K, Ishikura S, Tamura A, Akagawa M

The breakdown of collagenous networks with aging results in hypoactive changes in the skin. Accordingly, reviving stagnant collagen synthesis can help protect dermal homeostasis against aging. We searched for type I collagen biosynthesis-inducing substances in various foods using human dermal fibroblasts and found that cinnamon extract facilitates collagen biosynthesis. Cinnamon extract potently up-regulated both mRNA and protein expression levels of type I collagen without cytotoxicity. We identified cinnamaldehyde as a major active component promoting the expression of collagen by HPLC and NMR analysis. Since insulin-like growth factor-I (IGF-I) is the most potent stimulator of collagen biosynthesis in fibroblasts, we examined the effect of cinnamaldehyde on IGF-I signaling. Treatment with cinnamaldehyde significantly increased the phosphorylation levels of the IGF-I receptor and its downstream signaling molecules such as insulin receptor substrate-1 and Erk1/2 in an IGF-I-independent manner. These results suggested that cinnamon extract is useful in antiaging treatment of skin.–PMID: 22233457 [PubMed – indexed for MEDLINE]

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Hazelnuts- New Source of Key Fat for Infant Formula That’s More Like Mother’s Milk

 

ScienceDaily (May 23, 2012) — Scientists are reporting development of a healthy “designer fat” that, when added to infant formula, provides a key nutrient that premature babies need in high quantities, but isn’t available in large enough amounts in their mothers’ milk. The new nutrient, based on hazelnut oil, also could boost nutrition for babies who are bottle-fed for other reasons. The report appears in ACS’ Journal of Agricultural and Food Chemistry.—Casimir Akoh and colleagues explain that human milk is the “gold standard” for designing infant formulas. Mothers naturally provide the healthful omega-3 fatty acid DHA (docosahexaenoic acid) and omega-6 fatty acid ARA (arachidonic acid) — important for brain development and the development of other organs — to infants during the last three months of pregnancy. These fatty acids (components of fats) are also in human milk. But premature infants don’t get full exposure to DHA and ARA in the uterus because they are born too soon. And their mothers’ milk doesn’t yet contain high enough levels when the infants are born. Some mothers, of course, do not nurse. That’s why infant formulas include proteins, sugars and fats to bring them closer to the standard of human milk.—Currently, DHA and ARA (in the form of triacylglycerols) from algae are added to many formulas, but concerns exist about the digestibility of these algae-derived fatty acids, which are not exactly identical to those in human milk. So, Akoh’s team set out to build a new designer fat from hazelnut oil that more closely mimics the DHA and ARA in human milk. The report describes development of fats from hazelnut oil that contain DHA and ARA at the same positions found on fats in human milk. The scientists extensively analyzed these human milk fat mimics and conclude that the new DHA and ARA source is suitable for the supplementation of infant formulas.—Story Source-The above story is reprinted from materials provided by American Chemical Society, via EurekAlert!, a service of AAAS. —Journal Reference–Dilek Turan, Neşe Şahin Yeşilçubuk, Casimir C. Akoh. Production of Human Milk Fat Analogue Containing Docosahexaenoic and Arachidonic Acids. Journal of Agricultural and Food Chemistry, 2012; 60 (17): 4402 DOI: 10.1021/jf3012272

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Selenium and CoEnzyme Q 10-Cardiovascular mortality and N-terminal-proBNP reduced after combined selenium and coenzyme Q10 supplementation-

 

A 5-year prospective randomized double-blind placebo-controlled trial among elderly Swedish citizens

 

Selenium and coenzyme Q10 are essential for the cell. Low cardiac contents of selenium and coenzyme Q10 have been shown in patients with cardiomyopathy, but inconsistent results are published on the effect of supplementation of the two components separately. A vital relationship exists between the two substances to obtain optimal function of the cell. However, reports on combined supplements are lacking.—Methods–A 5-year prospective randomized double-blind placebo-controlled trial among Swedish citizens aged 70 to 88 was performed in 443 participants given combined supplementation of selenium and coenzyme Q10 or a placebo. Clinical examinations, echocardiography and biomarker measurements were performed. Participants were monitored every 6th month throughout the intervention.—The cardiac biomarker N-terminal proBNP (NT-proBNP) and echocardiographic changes were monitored and mortalities were registered. End-points of mortality were evaluated by Kaplan–Meier plots and Cox proportional hazard ratios were adjusted for potential confounding factors. Intention-to-treat and per-protocol analyses were applied.–Results—During a follow up time of 5.2 years a significant reduction of cardiovascular mortality was found in the active treatment group vs. the placebo group (5.9% vs. 12.6%; P = 0.015). NT-proBNP levels were significantly lower in the active group compared with the placebo group (mean values: 214 ng/L vs. 302 ng/L at 48 months; P = 0.014). In echocardiography a significant better cardiac function score was found in the active supplementation compared to the placebo group (P = 0.03).—Conclusion–Long-term supplementation of selenium/coenzyme Q10 reduces cardiovascular mortality. The positive effects could also be seen in NT-proBNP levels and on echocardiography.

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Commonly Used Pesticide Turns Honey Bees Into ‘Picky Eaters’

 

Using an ascending range of sugar water from 0 to 50 percent, the researchers touched the antennae of each bee to see if it extended its mouthparts.

ScienceDaily (May 24, 2012) — Biologists at UC San Diego have discovered that a small dose of a commonly used crop pesticide turns honey bees into “picky eaters” and affects their ability to recruit their nestmates to otherwise good sources of food.—The results of their experiments, detailed in this week’s issue of the Journal of Experimental Biology, have implications for what pesticides should be applied to bee-pollinated crops and shed light on one of the main culprits suspected to be behind the recent declines in honey bee colonies.—Since 2006, beekeepers in North America and Europe have lost about one-third of their managed bee colonies each year due to “colony collapse disorder.” While the exact cause is unknown, researchers believe pesticides have contributed to this decline. One group of crop pesticides, called “neonicotinoids,” has received particular attention from beekeepers and researchers.—The UC San Diego biologists focused their study on a specific neonicotinoid known as “imidacloprid,” which has been banned for use in certain crops in some European countries and is being increasingly scrutinized in the United States.—“In 2006, it was the sixth most commonly used pesticide in California and is sold for agricultural and home garden use,” said James Nieh, a professor of biology at UC San Diego who headed the research project with graduate student Daren Eiri, the first author of the study. “It is known to affect bee learning and memory.”—The two biologists found in their experiments that honey bees treated with a small, single dose of imidacloprid, comparable to what they would receive in nectar, became “picky eaters.”—“In other words, the bees preferred to only feed on sweeter nectar and refused nectars of lower sweetness that they would normally feed on and that would have provided important sustenance for the colony,” said Eiri. “In addition, bees typically recruit their nestmates to good food with waggle dances, and we discovered that the treated bees also danced less.”—The two researchers point out that honey bees that prefer only very sweet foods can dramatically reduce the amount of resources brought back to the colony. Further reductions in their food stores can occur when bees no longer communicate to their kin the location of the food source.—“Exposure to amounts of pesticide formerly considered safe may negatively affect the health of honey bee colonies,” said Nieh.—To test how the preference of sugary sources changed due to imidacloprid, the scientists individually harnessed the bees so only their heads could move. By stimulating the bees’ antennae with sugar water, the researchers were able to determine at what concentrations the sugar water was rewarding enough to feed on. Using an ascending range of sugar water from 0 to 50 percent, the researchers touched the antennae of each bee to see if it extended its mouthparts. Bees that were treated with imidacloprid were less willing to feed on low concentrations of sugar water than those that were not treated.–The biologists also observed how the pesticide affected the bees’ communication system. Bees communicate to each other the location of a food source by performing waggle dances. The number of waggle dances performed indicates the attractiveness of the reward and corresponds to the number of nestmates recruited to good food.—Remarkably, bees that fed on the pesticide reduced the number of their waggle dances between fourfold and tenfold,” said Eiri. “And in some cases, the affected bees stopped dancing completely.”—The two scientists said their discoveries not only have implications for how pesticides are applied and used in bee-pollinated crops, but provide an additional chemical tool that can be used by other researchers studying the neural control of honey bee behavior.—The study was funded by the North American Pollinator Protection Campaign and the National Science Foundation.–Story Source-The above story is reprinted from materials provided by University of California – San Diego. The original article was written by Kim McDonald. —Journal Reference-D. M. Eiri, J. C. Nieh. A nicotinic acetylcholine receptor agonist affects honey bee sucrose responsiveness and decreases waggle dancing. Journal of Experimental Biology, 2012; 215 (12): 2022 DOI: 10.1242/jeb.068718

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Persistent Sensory Experience Is Good for Aging Brain

 

ScienceDaily (May 24, 2012) — Despite a long-held scientific belief that much of the wiring of the brain is fixed by the time of adolescence, a new study shows that changes in sensory experience can cause massive rewiring of the brain, even as one ages. In addition, the study found that this rewiring involves fibers that supply the primary input to the cerebral cortex, the part of the brain that is responsible for sensory perception, motor control and cognition[U1] . These findings promise to open new avenues of research on brain remodeling and aging.—Published in the May 24, 2012 issue of Neuron, the study was conducted by researchers at the Max Planck Florida Institute (MPFI) and at Columbia University in New York.–“This study overturns decades-old beliefs that most of the brain is hard-wired before a critical period that ends when one is a young adult,” said MPFI neuroscientist Marcel Oberlaender, PhD, first author on the paper. “By changing the nature of sensory experience, we were able to demonstrate that the brain can rewire, even at an advanced age. This may suggest that if one stops learning and experiencing new things as one ages, a substantial amount of connections within the brain may be lost.”—The researchers conducted their study by examining the brains of older rats, focusing on an area of the brain known as the thalamus, which processes and delivers information obtained from sensory organs to the cerebral cortex. Connections between the thalamus and the cortex have been thought to stop changing by early adulthood, but this was not found to be the case in the rodents studied.—Being nocturnal animals, rats mainly rely on their whiskers as active sensory organs to explore and navigate their environment. For this reason, the whisker system is an ideal model for studying whether the brain can be remodeled by changing sensory experience. By simply trimming the whiskers, and preventing the rats from receiving this important and frequent form of sensory input, the scientists sought to determine whether extensive rewiring of the connections between the thalamus and cortex would occur.—On examination, they found that the animals with trimmed whiskers had altered axons, nerve fibers along which information is conveyed from one neuron (nerve cell) to many others; those whose whiskers were not trimmed had no axonal changes. Their findings were particularly striking as the rats were considered relatively old — meaning that this rewiring can still take place at an age not previously thought possible. Also notable was that the rewiring happened rapidly — in as little as a few days.—“We’ve shown that the structure of the rodent brain is in constant flux, and that this rewiring is shaped by sensory experience and interaction with the environment,” said Dr. Oberlaender. “These changes seem to be life-long and may pertain to other sensory systems and species, including people. Our findings open the possibility of new avenues of research on development of the aging brain using quantitative anatomical studies combined with noninvasive imaging technologies suitable for humans, such as functional MRI (fMRI).”

The study was possible due to recent advances in high-resolution imaging and reconstruction techniques, developed in part by Dr. Oberlaender at MPFI. These novel methods enable researchers to automatically and reliably trace the fine and complex branching patterns of individual axons, with typical diameters less than a thousandth of a millimeter, throughout the entire brain.–Dr. Oberlaender is part of the Max Planck Florida Institute’s Digital Neuroanatomy group, led by Nobel laureate Dr. Bert Sakmann. The group focuses on the functional anatomy of circuits in the cerebral cortex that form the basis of simple behaviors (e.g. decision making). One of the group’s most significant efforts is a program dedicated to obtaining a three-dimensional map of the rodent brain. This work will provide insight into the functional architecture of entire cortical areas, and will lay the foundation for a mechanistic understanding of sensory perception and behavior.-This study was carried out in collaboration with the group of Dr. Randy M. Bruno in the Neuroscience Department of Columbia University, New York.–Story Source-The above story is reprinted from materials provided by Max Planck Florida Institute. —Journal Reference-Marcel Oberlaender, Alejandro Ramirez, Randy M. Bruno. Sensory Experience Restructures Thalamocortical Axons during Adulthood. Neuron, 2012; 74 (4): 648 DOI: 10.1016/j.neuron.2012.03.022

Mind Exercises to increase Sensory Experience Restructuring-A good way to do this is to study about certain things and then place your self in the environment or setting and investigate or carry out a perception exercise—an example might be to do a recipe—or go out and take pictures read about the perspective subject you want to photograph and from there go and explore if the subject facts are accurate and write down what you observe—seek out different environments that will cause you to expand this effect so you develop new skills with the brain—further your education in new elements to further enhance te brain keeping it active and viable

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[U1]This is Great News—If you are set in your ways and seem to be stuck on negative repetitive behaviour then this is showing there is a ways and  means to change this thinking pattern and or associations in thought—Negative aspect of this also infers the idea that people of all ages can be brain washed as well with new concepts

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